| Project/Area Number |
12480266
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | TOKYO METROPOLITAN UNIVERSITY |
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Principal Investigator |
NAGAOKA Shoji Tokyo Metropolitan Univ., Dept of Applied Chemistry, Professor, 大学院・工学研究科, 教授 (30254147)
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| Co-Investigator(Kenkyū-buntansha) |
OWADA Sigeru St. Marianna University, School of Medicine, Associate Professor, 助教授 (40103486)
KANAMORI Toshiyuki Institute for Materials and Chemical Process, AIST Senior Researcher, 主任研究員
KAWAKAMI Hiroyoshi Tokyo Metropolitan Univ., Dept. of Applied Chemistry, Associate Professor, 大学院・工学研究科, 助教授 (10221897)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Blood Purification / Ultra filtration / Fluorinated Polyimide / Asymmetric Hollow Fiber / Fouling / Pore Size / Blood Compatibility / Tangential Module / ファウリング / 血液浄化 / 持続的血液濾過膜 / 中空糸膜 |
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| Research Abstract |
We report the application of aromatic fluorinated polyimide (6FDA-6FAP) to high performance continuous blood purification system for acute renal failure. For this purpose, a series of porous polyimide membranes were fabricated by different conditions, and micro to nanofiltration membranes was obtained. We focused on a wet phase inversion process as method for preparing a novel porous membrane, since the membrane with nano-order-scale fine structure designed from nanoscale nodule or pore sizes is of great interest in areas such as medical device for clinical use. The obtained membrane showed good ultra filtration rate and anti-fouling property. The various conditions to fabricate asymmetric porous hollow fiber were determined. Also, we found that the porous membrane showed excellent blood and immune compatibility both in vivo and in vitro by the selective and oriented adsorption of IgG on the surface. We have manufactured for trial the tangential module for clinical use.
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