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Development of High Performance Blood Purification System using Novel Aromatic Polyimide Hollow Fiber

Research Project

Project/Area Number 12480266
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTOKYO METROPOLITAN UNIVERSITY

Principal Investigator

NAGAOKA Shoji  Tokyo Metropolitan Univ., Dept of Applied Chemistry, Professor, 大学院・工学研究科, 教授 (30254147)

Co-Investigator(Kenkyū-buntansha) OWADA Sigeru  St. Marianna University, School of Medicine, Associate Professor, 助教授 (40103486)
KANAMORI Toshiyuki  Institute for Materials and Chemical Process, AIST Senior Researcher, 主任研究員
KAWAKAMI Hiroyoshi  Tokyo Metropolitan Univ., Dept. of Applied Chemistry, Associate Professor, 大学院・工学研究科, 助教授 (10221897)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥4,700,000 (Direct Cost: ¥4,700,000)
KeywordsBlood Purification / Ultra filtration / Fluorinated Polyimide / Asymmetric Hollow Fiber / Fouling / Pore Size / Blood Compatibility / Tangential Module / ファウリング / 血液浄化 / 持続的血液濾過膜 / 中空糸膜
Research Abstract

We report the application of aromatic fluorinated polyimide (6FDA-6FAP) to high performance continuous blood purification system for acute renal failure. For this purpose, a series of porous polyimide membranes were fabricated by different conditions, and micro to nanofiltration membranes was obtained. We focused on a wet phase inversion process as method for preparing a novel porous membrane, since the membrane with nano-order-scale fine structure designed from nanoscale nodule or pore sizes is of great interest in areas such as medical device for clinical use. The obtained membrane showed good ultra filtration rate and anti-fouling property. The various conditions to fabricate asymmetric porous hollow fiber were determined. Also, we found that the porous membrane showed excellent blood and immune compatibility both in vivo and in vitro by the selective and oriented adsorption of IgG on the surface. We have manufactured for trial the tangential module for clinical use.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Nagaoka S., Kawakami H.et al.: "Evaluation of blood compatibility of fluorinated polyimide by immunolabelling assay"J.Artif.Organs. 4(2). 107-112 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Niwa M., Kawakami H., Nagaoka S., et al.: "Gas Separation of Asymmetric 6FDA Polyimide Membrane with Surface Skin Layer"Macromolecules. 34(26). 533-542 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Niwa M., Kawakami H., Nagaoka S., et al.: "Gas transfer and blood compatibility of asymmetric polyimide hollow fiber"J.Biomat.Sci.Ploym.Edn.. 12(5). 533-542 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kawakami H., Takahashi, T.Nagaoka S.et al.: "Albumin Adsorption to Surface of Annealed Fluorinated Polyimide"Polym.Adv.Technol.. 12. 244-252 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanno M., Kawakami H., Nagaoka S.et al.: "Biocompatibility of Fluorinated Polyimide"J.Biomed.Mater.Res.. (印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanamori T, . Shinbo T.: "Mass transfer of a solute by diffusion with convection around a single hollow-fiber membrane for hemodialysis"Desalination. 129. 217-225 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Niwa, H. Kawakami, T. Kanamori, T. Shinbo, A. Kaito and S. Nagaoka: "Gas Separation of Asymmetric 6FDA Polyimide Membrane with Oriented Surface Skin Layer"Macromolecules. 34. 9039-9044 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Nagaoka, M. Kanno, H. Kawakami and S. Kubota: "Evaluation of Blood Compatibility of Fluorinated Polyimide by Immunolabelling Assay"J. Artif. Organs. 4. 107-112 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Niwa, H. Kawakami, S. Nagaoka, T. Kanamori and T. Shinbo: "Gas transfer and blood compatibility of asymmetric polyimide hollow fiber"J. Biomater. Sci., Polym. Ed.. 12. 533-542 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Kanamori and T. Shinbo: "Mass transfer of a solute by diffusion with convection around a single hollow-fiber membrane for hemodialysis"Desalination. 129. 217-225 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Owada, T. Tsukamoto, K. Toyama, M. Komurai, M. Ominato, Y. Ishii and T. Sato: "Erythrocyte redox state in hemodialyzed patients : glutathione and glutathiohe-related enzymes"J. Artif. Organs. 4. 8-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Kawakami, T. Takahashi, S. Nagaoka, and Y. Nakayama: "Albumin Adsorption to Surface of Annealed Fluorinated Polyimide"Polym. Adv. Technol. 12. 244-252 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Kanamori, M. Niwa, H. Kawakami, Y. Mori, S. Nagaoka, and T. Shinbo: "Preparation of Asymmetric Hollow-Fiber Membrane with Ultrathin Dense Skin"Macromol. Sympo.. 160. 233-237 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagaoka S., Kawakami H et al.: "Evaluation of bood compatibility of fluorinated polyimide by immunolabeling assay"J.Artif.Organs. 4(2). 107-112 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Niwa M., Kawakami H., Nagaoka S et al.: "Gas Separation of Asymmetric 6FDA Polyimide Membrane with Oriented Surface Skin Layer"Macromolecules. 34(26). 9039-9044 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] KawakamiH., Nagaoka S.et al.: "Albumin Adsorption to Surface of Annealed Fluorinated Polyimide"Polym.Adv.Technol.. 12. 244-252 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 川上 浩良: "相転換法による膜構造制御(総説)"膜. 26(3). 110-115 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kanamori, T., Shinbo, T.et al.: "Development of Artificial Lung for Long-Term Use Using Hollow-Fiber"New Tech.Jpn.. 28. 11-12 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Owada S, Tsukamoto T. et al.: "Erythrocyte redox state in hemodialyzed patients : glutathione and glutathione-related enzymes"J.Artif.Organs. 4(1). 8-18 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Niwa,H.Kawakami.S.Nagaoka: "Fabrication of an asymmetric polyimide hollow fiber with a defect-free surface skin layer"Journal of Membrane Science. 171. 253-261 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Kanamori,H.Kawakami S,Nagaoka: "An Estimate of Gas Transfer Rates of Intravascular Membrane Oxygenator(IVOX)"ASAIO Journal. 46. 612-619 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Kanamori,H.Kawakami,S.Nagaoka: "Preparation of Asymmetric Hollow-fiber Membrane with Ultrathin Dense Skin Layer on the Outer Surface Using Dry/Wet Phase Inversion Process"Macromol,Symp.. 160. 233-237 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Kawakami,S.Nagaoka: "Albumin adsorption to surface of annealed fluorinated polyimide"Polym.Adv.Technol. 12. 1-9 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Nagaoka,H.Kawakami: "Evaluation of Blood compatibility of Fluorinated Polyimide by Immunolabelling Assay"Journal of Arificial Organs. 4(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 長岡昭二: "医療デバイス・人工臓器の表面処理(総説)"表面. 11. 507-516 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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