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Study of human exposure assessment of chemical materials in daily life and their endocrine disrupting activity.

Research Project

Project/Area Number 12490030
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 広領域
Research InstitutionHoshi University

Principal Investigator

NAKAZAWA Hiroyuki  Faculty of Pharmaceutical Scienses, Hoshi University, Dept. of Anal. Chem., Professor, 薬品分析化学教室, 教授 (50150173)

Co-Investigator(Kenkyū-buntansha) INOUE Koichi  Faculty of Pharmaceutical Scienses, Hoshi University, Dept. of Anal. Chem., Research Associate, 薬品分析化学教室, 助手 (30339519)
KATO Kayoko  Faculty of Pharmaceutical Scienses, Hoshi University, Dept. of Anal. Chem., Research Associate, 薬品分析化学教室, 助手 (70233781)
YOSHIMURA Yoshihiro  Faculty of Pharmaceutical Scienses, Hoshi University, Dept. of Anal. Chem., Associate Professor, 薬品分析化学教室, 助教授 (00147894)
渡辺 卓穂  星薬科大学, 薬学部, 助手 (80210912)
岡田 由美子  国立公衆衛生院, 衛生獣医学部, 研究員 (50232137)
山崎 聖美  国立公衆衛生院, 栄養生化学部, 主任研究官 (00218439)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2002: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsEndocrine disrupting chemicals / Synthetic chemical / Human biological sample / GC / MS / LC / Human exposure / Food contamination / 内分泌かく乱化学物質 / 生体曝露 / in vitro assay / 可塑剤 / フタル酸ジエチルヘキシン / 雄性生殖 / テストステロン / カラムスイッチング / 植物エストロジェン / E-Screen assay / ノニルフェノール / ビスフェノール / イソフラボン / キャピラリー電気泳動法 / 質量分析計
Research Abstract

Endocrine disrupting chemicals (EDCs) consist of synthetic and naturally occurring chemicals that affect the balance of hormonal functions in humans and animals. Some pesticides and industrial chemicals can affect animal physiology by mimicking the effects of endogenous hormones. The potential risks to human health and reproduction from the EDCs have not been well established. This is due in part to the absence of the accurate analytical methods to quantify EDCs in human biological samples and the in vitro assay of estrogenic activity for risk assessment of the EDCs to human. In this study we establish an accurate, sensitive and selective analytical method for the quantification of EDCs such as bisphenol A (BPA), hisphenol A diglycidyl ether (BADGE), alkylphenols, phthalate esters and isoflavones in human biological samples. In addition, the estrogenic activity of many synthetic chemicals was investigated by using cell proliferation assay and receptor competitor binding assay.
We have a … More chieved the study of BPA migration in canned drink and other food-stuff and the investigation of the possibility of contamination of honey. Because of these studies of BPA and their potential role in increasing risk for reproductive dysfunction and cancer, the need for an assessment of human exposure is urgent. Therefore, we developed the methods for measurement of BPA and BADGE metabolites in human biological samples by HPLC, LC/MS and GC/MS, and the assays for estimation of estrogenic activity of these chemicals by cell proliferation and receptor binding effects. On the other hands, some estrogenic chemicals were reported to be leached out from such PVC products such as food wrapping films, medical devices. In this reason, we employed column-switching LC/MS coupled with on-line extraction for the sensitive, selective and accurate determination of EDCs in respet with the PVC products. This method was successfully used to determinate EDCs in human biological samples from healthy humans, and the main, source of human exposure was clarify. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (68 results)

All Other

All Publications (68 results)

  • [Publications] Inoue, K., Wada, M., Higuchi, T., Oshio, S., Umeda, T.: "Application of liquid chromatography -mass spectrometry to the quantification of bisphenol A in human semen"J.Chromatogr.B. 773. 97-102 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Yoshie, Y., Kondo, S., et al.: "Determination of phenolic xenoestrogens in water by liquid chromatography with coulometric-array detection"J.Chromatogr.A. 946. 291-294 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimura, Y., Brock, J.W., Makino, T., Nakazawa, H.: "Measurement of bisphenole A in human serum by GC/MS"Anal.Chim.Acta. 458. 331-336 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, K., Yoshimura, Y., Ito, Y., Oka, H., Nakazawa, H.: "Preparation of samples for gas chromatography/mass spectrometry analysis of phthalate and adipate esters in plasma and beverages by steam dislillation and extaction"AOAC Int.. 85. 719-723 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Okumura, H., Higuchi, T., Oka, H., et al.: "Characterization of estrogenic compounds in medical polyvinyl chloride tubing by gas chromatography-mass spectrometry and estrogen receptor assay"Clin.Clim.Acta. 325. 157-163 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakazawa, H., Yamaguchi, A., Inoue, K., Yamazaki, T., Kato, K., Yoshimura, Y., Makino, T.: "In vitro assay of hydrolysis and chlorahydoroxy derivatives of bisphenol A diglycidyl ether for estrogenic activity"Food Chem.Toxicol.. 40. 1827-1832 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 井之上浩一, 小林 直, 吉村吉博, 堀江正一, 中澤裕之: "エストロゲン受容体結合試験による食品用ポリ塩化ビニル製ラップフィルムの残留化学物質の評価"Jpn.J.Food Chem.. 9. 46-49 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, K., Shoda, S., Yoshimura, Y., Takahashi, M., Doi, N., Nakazawa, H.: "Determination of three phthalate monoesters in human urine using on-line solid phase extraction-liquid chromatography-tandem mass spectrometry"J.Chromatogr.B. 788. 407-411 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Kawaguchi, M., Okada, F., Yoshimura, Y., Nakazawa, H.: "Column-switching high-performance liquid chromatography electrospray mass spectrometry coupled with on-line of extraction for the determination of mono-and di-(2-ethyhexyl)phthalate in blood samples"Anal.Bioanal.Chem.. 375. 527-533 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Higuchi, T., Okada, F., Iguchi, H., Yoshimura, Y., Sato, A., Nakazawa, H.: "The validation of column-switching LC/MS as a high throughput approach for direct analysis of di(2-ethylhexyl) phthalate released from PVC medical devices in intravenous solution"J.Pharm.Biomed.Anal.. 31. 1145-1152 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Murayama, S., Yoshimura, Y., Nakazawa, H.: "Contamination of xenoestrogens bisphenol A and F in honey : Safety assessment and analytical method of these compounds in honey"J.Food.Compos.Anal.. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, K., Yamaguchi, T., Higashiyama, K., Nakazawa, H.: "High throughtput analysis of di-(2-ethylhexyl)phthalate metabolites in urine for exposure assessment"J.Liq. Chromatogr.Relat.Technol.. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Kawaguchi, M., Okada, F., Takai, N., Yoshimura, Y., Horie, M.: "Measurement of 4-nonylphenol and 4-tert-octylphenol in human urine by column-switching LC/MS coupled with on-line extraction"Anal.Chim.Acta. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, K., Silva, M., Brock, J., Reidy, J., Malek, N., Hodge, C., Nakazawa, H., Needham, D.: "Quantitative detection of nine phthalate metabolites in human serum using reversed phase high performanced liquid chromatography/electrospray ionization-tandem mass spectrometry"Anal.Toxicol.. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 加藤嘉代子, 中澤裕之(分担執筆): "環境ホルモンの最新動向と測定試験、機器開発"シーエムシー出版. 168-173 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., KAWAGUCHI M., OKADA, F., YOSHIMURA, Y. AND NAKAZAWA, H.: "Column-switching high-performance liquid chromatography electrospray mass spectrometry coupled with on-line of extraction for the determination of mono- and di-(2-ethylhexyl) phthalate in blood samples."Anal. Bioanal. Chem.. 375. 527-533 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INDUE, K., HIGUCHI, T., OKADA, F., IGUCHI, H., YOSHIMURA, Y., SATO, A. AND NAKAZAWA, H.: "The validation of column-switching LC/MS as a high-throughput approach for direct analysis of di(2-ethylhexyl) phthalate released from PVC medical devices in intravenous solution"J. Pharm. Biomed. Anal.. 31. 1145-1152 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] SUZUKI, T., MIZUO, K., NAKAZAWA, H., FUNAE, Y., FUSHIKI, S., FUKUSHJMA, S., SHTRAI, T. AND NARITA, M.: "Prenatal and neonatal exposure to bisphenol A enhances the central dopamine D1 receptor-mediated action in mice: enhancement of the methamphetamine -induced abuse state."Neuroscience. 117. 639-644 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., MURAYAMA, S., TAKEBA, K, YOSHIMURA, Y. AND NAKAZAWA, H.: "Contamination of xenoestrogens bisphenol A and F in honey: safety assessment and analytical method of these compounds in honey"J. Food Compos. Anal.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] KATO, K., SHODA, S., TAKAHASHI, M., DOI, N., YOSHIMURA, Y. AND NAKAZAWA, H.: "Determination of three phthalate metabolites in human urine using on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry"J. Chromatogr. B. 788. 407-411 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] KATO, K., SILVA, M., BROCK, W.J., REIDY, J., MALEK, N., HODGE, C., NAKAZAWA, H., NEEDHAM, L. AND BARR, D.: "Quantitative detection of nine phthalate metabolites in human serumusing reversed phase high performance liquid chromatography/electrospray ionization-tandem mass spectrometry."Anal. Toxicol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] KATO, K., YAMAUCHI, T., HIGASHIYAMA, K. AND NAKAZAWA, H.: "High throughput analysis of di-(2-ethyheryl)phthalate metabolite urine for exposure assessment."J. Liq. Chromtogr. Relat. Technol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K, YOSHIMURA, Y., MAKINO, T. AND NAKAZAWA, H.: "Determination of 4-nonylphenol and 4-octylphenol in human blood samples by high-performance liquid chromatography with multi-electrode electrochemical coulometric-array detection."Analyst. 125. 1959-1961 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K, KATO, K., YOSHIMURA, Y., MAKINO, T. AND NAKAZAWA, H.: "Determination of bisphenol A in human serum by high-performance liquid chromatography with multi-electrode electrochemical detection."J. Chromatogr. B. 749. 17-23 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] YOSHIDA, T., HORIE, M., HOSHINO, Y. AND NAKAZAWA, H.: "Determination of bisphenol A in canned vegetables and fruit by high performance liquid chromatography."Food Addit, Contam.. 18. 69-75 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., KONDO, S., YOSHIE, Y., KATO, K., YOSHIMURA, Y., HORIE, M. AND NAKAZAWA, H.: "Migration of 4-nonylphenol from polyvinyl chloride food packaging films into food simulants and foods."Food Addit Contam.. 18. 157-164 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] HIRAYAMA, K., TANAKA, H., KAWANA, K., TANI, T. AND NAKAZAWA, H.: "Analysis of plasticizers in cap-sealing resins for bottled foods."Food Addit. Contam.. 18. 357-362 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] BROCK, J.W., YOSHIMURA, Y., BARR, J.R., MAGGIO, V.L., GRAISER, S.R., NAKAZAWA, H., AND NEEDHAM, L.L.: "Measurement of bisphenol A levels in human urine."J. Exp. Anal. Environ. Epid.. 11. 323-328 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., YAMAGUCHI, A., WADA, M., YOSHIMURA, Y., MAKINO, T. AND NAKAZAWA, H.: "Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma using liquid chromatography - electrospray mass spectrometry."J. Chromatogr. B. 765. 121-126 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] YOSHIMURA, Y., BROCK, J.W., MAKINO, T. AND NAKAZAWA,H.: "Measurement of Bisphenole A in human serum by GC/MS."Anal. Chim. Acta. 458. 331-336 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] KATO.K., YOSHIMURA, Y., ITO, Y., OKA, H. AND NAKAZAWA, H.: "Preparation of samples for gas chromatography/mass spectrometry analysis of phthalate and adipate esters in plasma and beverages by steam dislillation and extaction."AOAC Int.. 85. 719-723 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., YOSHIE, Y., KONDO, S., YOSHIMURA, Y. AND NAKAZAWA, H.: "Determination of phenolic xenoestrogens in aquatic samples by high- performance liquid chromatography with electrochemical coulometric-array detection."J. Chromatogr. A. 946. 291-294 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., WADA, M., HIGUCHI, T., OSHIO, S., UMEDA, T., YOSHIMURA, Y., AND NAKAZAWA, H.: "Application of liquid chromatography-mass spectrometry to the quantification of bisphenol A in human semen."J. Chromatogi. B. 773. 97-102 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., KOBAYASHI, N., YOSHIMURA, Y., HORIE, M., AND NAKAZAWA, H.: "Estimation of estrogenic activity of polyvinyl chloride films for food-wrapping by estrogen receptor binding assay."Jpn. J. Food Chem.. 9. 46-49 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., OKUMURA, H., HIGUCHI, T., OKA, H., YOSHIMURA, Y. AND NAKAZAWA, H.: "Characterization of estrogenic compounds in medical polyvinyl chloride tubing by gas chromatography-mass spectrometry and estrogen receptor assay."Clin. Chim. Acta. 325. 157-163 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] NAKAZAWA, H., YAMAGUCHI, A., INOUE, K., YAMAZAK, T., KATO, K., YOSHIMURA, Y. AND MAKINO, T.: "In vitro assay of hydrolysis and chlorohydoroxy derivatives of bisphenol A diglycidyl ether for eatrogenic activity."Food Chem. Toxicol.. 40. 1827-1832 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] INOUE, K., KAWAGUCHI, M., OKADA, F., TAKAI, N., YOSHIMURA, Y., HORIE, M., IZUMI, S., MAKINO, T., AND NAKAZAWA, H.: "Measurement of 4-nonylphenol and 4-tert-octylphenol in human urine by column-switching LC/MS coupled with on-line extraction."Anal. Chim. Acta. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue, K., Wada, M., Higuchi, T., Oshio, S, Umeda, T., Yoshimura, Y., Nakazawa, H.: "Application of liquid chromatography -mass spectrometry to the quantification of bisphenol A in human semen"J. Chrornatogr. B. 773. 97-102 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, K., Yoshie, Y., Kondo, S., Yoshimura, Y., Nakazawa, H.: "Determination of phenolic xenoestrogens in water by liquid chromatography with coulometric-array detection"J. Chromatogr. A. 946. 291-294 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshimura, Y., Brock, J.W., Makino, T., Nakazawa, H.: "Measurement of bisphenole A in human serum by GC/MS"Anal. Chim. Acta. 458. 331-336 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato, K., Yoshimura, Y., Ito, Y., Oka, H., Nakazawa, H.: "Preparation of samples for gas chromatography/mass spectrometry analysis of phthalate and adipate esters in plasma and beverages by steam dislillation and extaction"AOAC Int.. 85. 719-723 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, K., Okumura, H., Higuchi, T., Oka, H., Yoshimura, Y., Nakazawa, H.: "Characterization of estrogenic compounds in medical polyvinyl chloride tubing by gas chromatography-mass spectrometry and estrogen receptor assay"Clin. Chim. Acta. 325. 157-163 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakazawa, H., Yamaguchi, A., Inoue, K., Yamazaki, T., Kato, K., Yoshimura, Y., Makino, T.: "In vitro assay of hydrolysis and chlorohydoroxy derivatives of bisphenol A diglycidyl ether for estrogenic activity"Food Chem. Toxicol.. 40. 1827-1832 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 井之上浩一, 小林 直, 吉村吉博, 堀江正一, 中澤裕之: "エストロゲン受容体結合試験による食品用ポリ塩化ビニル製ラップフィルムの残留化学物質の評価"Jpn. J. Food Chem.. 9. 46-49 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato, K., Shoda, S., Yashimura, Y., Takahashi, M., Doi, N., Nakazawa, H.: "Determination of three phthalate monoesters in human urine using on-line solid phase extraction-liquid chromatography-tandem mass spectrometry"J. Chromatogr. B. 788. 407-411 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, K., Kawaguchi, M., Okada, F., Yoshimura, Y., Nakazawa, H.: "Column-switching high-performance liquid chromatography electrospray mass spectrometry coupled with on-line of extraction for the determination of mono-and di-(2-ethyhexyl)phthalate in blood samples"Anal. Bloanal. Chem.. 375. 527-533 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, K., Higuchi, T., Okada, F., Iguchi, H., Yoshimura, Y., Sato, A., Nakazawa, H.: "The validation of column-switching LC/MS as a high-throughput approach for direct analysis of di(2-ethylhexyl) phthalate released from PVC medical devices in intravenous solution"J. Pharm. Biomed. Anal.. 31. 1145-1152 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, K., Murayama, S., Yoshimura, Y., Nakazawa, H.: "Contamination of xenoestrogens bisphenol A and F in honey : Safety assessment and analytical method of these compounds in honey"J. Food Compos. Anal.. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato, K., Yamaguchi, T., Higashiyama, K., Nakazawa, H.: "High throughtput analysis of di-(2-ethylhexyl)phthalate metabolites in urine for exposure assessment"J. Liq. Chromatogr. Relat. Technol.. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, K., Kawaguchi, M., Okada, F., Takai, N., Yashimura, Y., Horie, M., Izumi, S., Makino, T., Nakazawa, H.: "Measurement of 4-nonylphenol and 4-tert-octylphenol in human urine by column-switching LC/MS coupled with on-line extraction"Anal. Chim. Acta. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato, K., Silva, M., Brock, J., Reidy, J., Malek, N., Hodge, C., Nakazawa, H., Needham, D.: "Quantitative detection of nine phthalate metabolites in human serum using reversed phase high performanced liquid chromatography/electrospray ionization-tandem mass spectrometry"Anal. Toxicol.. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 加藤嘉代子, 中澤裕之(分担執筆): "環境ホルモンの最新動向と測定試験、機器開発"シーエムシー出版. 168-173 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Inoue, S.Kondo, Y.Yoshie, K.Kato, Y.Yoshimura, M.Horie, H.Nakazawa: "Migration of 4-nonylphenol from polyvinyl chloride films for food-wrapping into food simulants and foods"Food Additives & Contaminants. 18. 157-164 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Watanabe, H Yamamoto, K.Inoue, A.Yamaguchi, Y.Yoshimura, K.Kato, H.Nakazawa, N.Kuroda, K.Nakashima: "Development of sensitive high-performance liquid chromatography with fluorescence detection using 4-(4,5-diphenyl-1H-imidazol-2-yl) benzoyl chloride as a labeling reagent for determination of bisphenol A in plasma samples"Journal of Chromatography B. 762. 1-7 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Inoue, A.Yamaguchi, M.Wada, Y.Yoshimura, T.Makino, H.Nakazawa: "Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma using liquid chromatography-electrospray mass spectrometry"Journal of Chromatography B. 765. 121-126 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 河村葉子, 井之上浩一, 中澤裕之, 山田 隆, 米谷民雄: "飲料缶からのビスフェノールA移行原因の解明と改良缶の評価"食品衛生学雑誌. 42. 13-17 (2001)

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  • [Publications] K.Inoue, Y.Yoshie, S.Kondo, Y.Yoshimura, H.Nakazawa: "Determination of phenolic xenoestrogens in water by liquid chromatography with coulometric-array detection"Journal of Chromatography A. 946. 291-294 (2002)

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  • [Publications] K.Inoue, M.Wada, T.Higuchi, S.Oshio, T.Umeda, Y.Yoshimura, H.Nakazawa: "Application of liquid chromatography -mass spectrometry to the quantification of bisphenol A in human semen"Journal of Chromatography B. (In press). (2002)

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  • [Publications] 中澤裕之, 辰濃 隆編集: "「内分泌かく乱化学物質と食品容器」"幸書房. 180 (1999)

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  • [Publications] 中澤裕之 (分担執筆): "季刊化学総説 「内分泌かく乱物質研究の最前線」"日本化学会編 学会出版センター. 224 (2001)

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  • [Publications] K.Inoue,Y.Yoshimura,T.Makino and H.Nakazawa: "Determination of 4-nonylphenol and 4-octylphenol in human blood samples by high-performance liquid chromatography with multi-electrode electrochemical coulometric-arrav"Analyst,. 125.. 1959-1961 (2000)

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  • [Publications] K.Inoue,Y.Yoshimura,T.Makino and H.Nakazawa: "Determination of bisphenol A in human serum by high-performance liquid chromatography with multi-electrode electrochemical detection"J.Chromatogr.A. 749,. 17-23 (2000)

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  • [Publications] K.Inoue,S.Kondo,Y.Yoshie,K.Kato,Y.Yoshimura,M.Horie and H.Nakazawa: "Migration of 4-nonylphenol from polyvinyl chloride films for food-wrapping into food simulants and foods"Food Additives & Contaminants. 18(2). 157-164 (2000)

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  • [Publications] 中澤裕之: "ヒト生体試料中の内分泌かく乱化学物質の分析"食品衛生研究. 50(6). 93-99 (2000)

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  • [Publications] Y,Sun,M.Wada,O.A.Dirbashi,N.Kuroda,H.Nakazawa,K.Nakashima: "High-performance liquid chromatography with peroxylate chemiluminescence detection of bisphenol A migrated from polycarbonato baby bottles using 4-(4,5-diphenyl-1H-imidazol-2-yl) benzoyl chloride as a label"J.Chromatogr.B.,. 749,. 49-56 (2000)

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  • [Publications] 中澤裕之,井之上浩一: "食品に関係する内分泌かく乱化学物質"食品衛生. No.522. 8-17 (2000)

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  • [Publications] 中澤裕之,辰濃隆 編集: "内分泌かく乱化学物質と食品容器"幸書房. 183 (1999)

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  • [Publications] 中澤裕之(監修): "生活関連化学物質データブック"林純薬工業. 319 (1999)

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Published: 2000-04-01   Modified: 2016-04-21  

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