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Iodine laser development which oscillates with singlet delta oxygen produced by electric discharge, and its application for biological tissue fusion

Research Project

Project/Area Number 12555019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Applied physics, general
Research InstitutionAnan College of Technology

Principal Investigator

FUJII Hiroo  Anan College of Technology, Mechanical Engineering, Professor, 機械工学科, 教授 (00291980)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Hideki  Tokushima University, Medical Department, Professor, 医学部附属病院, 教授 (90164235)
NAKAMURA Yuichi  Electrical Engineering, Assistant Professor, 電気電子工学科, 助教授 (40259940)
ITAMI Shin  Control and Information Engineering, Lecturer, 制御情報工学科, 講師 (60212982)
MURO Mikio  Kawasaki Heavy Industries, Ltd., Opt-Engineering Lab., Manager, 課長
HASHIMOTO Ichiro  Tokushima University, Medical Department, Assistant, 医学部附属病院, 助手 (70314870)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 2002: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywordsiodine laser / singlet delta oxygen / discharge excitation / yield / discharge oxygen-iodine laser / medical laser / biological tissue fusion / artery welding / ヨウ素レーザー / E / N / 医療用レーザー / 酸素励起率 / 微小血管吻合 / 吻合部動脈瘤 / プラズマジェット / ホロー電極
Research Abstract

The Discharge Oxygen-Iodine Laser (DOIL) has been developed for the application of airborne laser system in Europe and the U.S. Especially, CU-Aerospace Co. in the US, who is our biggest competitor, is doing DOIL research very actively under a budget of US Air Force. After having detected the light amplification of DOIL emission first in the world in 2000, we have been trying to achieve mW power out-put by improving the system till the end of May 2003. But not only us but foreign teams can clear this target. Fruitful results, which obtained through this 3 years research term, are that 3 items, i.e.; increasing yield, iodine dissociation and laser gas cooling, are picked up for the mW power out-put, and feasible targets and the design data are established for each item. Fortunately, we are successful in getting a new budget for the DOIL research and doing big efforts for achieving oscillation on 2004.
Concerning laser application for biological tissue fusion, welding tests of the main artery at a rat stomach were carried out using YAG laser beam which has a similar wavelength of DOIL. From the tissue scholarly view at fused position, it can be said that the abnormal reaction by foreign substance was hardly accepted, the fused tissue was recovered earlier by the laser than by the thread, and the constriction condition which appeared at early stage was soon disappeared. In order to suppress the aneurysm generation which tend to appear in this method, the fusion position was reinforced by covering artery with muscles film. As the results, the aneurysm completely disappeared and complications, such as denaturation or necrosis of fused tissue, were not observed for long-term. We conclude that the laser fusion on artery is an excellent method with the muscles film reinforcement.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Hiroo Fujii: "Hybrid oxygen iodine laser with a discharge singlet oxygen generator"SPIE. Vol.4065. 818-825 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Josef Schmiedberger: "RF Plasma Jet Generation of Singlet Delta Oxygen for Oxygen Iodine Laser"SPIE. Vol.4184. 32-35 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 木原義文: "放電式ヨウ素レーザの発振実験"研究紀要(阿南高専). 37号. 67-72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤井洋郎: "医療応用を目的とした新型近赤外レーザシステムの開発"STEPテクノ情報誌. 7巻1号. 8-9 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 原田浩史: "糖尿病における皮膚微小循環障害"日本形成外科学会誌. 20号. 258-264 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Hashimoto: "The Gluteal Fold Flap for Vulvar and Buttock Reconstruction"Plastic and Reconstructive Surgery. Vol.108,No7. 1998-2005 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo Fujii: "Radio-frequency plasma jet generator of singlet delta oxygen with high yield"Applied Physics Letters. Vol.78,No18. 2649-2651 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤井洋郎: "放電励起酸素ヨウ素レーザーに用いる励起酸素発生器"レーザー研究. Vol.29,No9. 605-609 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 木原義文: "放電式ヨウ素レーザ用励起酸素発生器の性能試験"信学技放レポート. MBE2001-57. 31-35 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Hashimoto: "First cutaneous branch of the first pudendal artery : An anatomical basis for the so-called gluteal fold flap"Okajima Folia Anatomica Japonica. Vol.78,No1. 23-30 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo Fujii: "RF plasma jet generation of singlet delta oxygen in chilled and energy transfer modes for oxygen iodine laser"SPIE. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Hashimoto: "The Features of Thrombus in a Mierovessel Injury Model and the Antithrombotic Efficeacy of Heparin, Urokinase, and Prostaglandin El"Plastic and Reconstructive Surgery. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Hashimoto: "Angiostatic effects of corticosteroid on wound healing of the rabbir ear"The Journal of Medical Investigation. 49,1-2. 61-66 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo.Fujii: "Hybrid oxygen iodine laser with a discharge singlet oxygen generator"SPIE. Vol.4065. 818-825 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Josef Schmiedberger: "RF plasma jet generation of singlet delta oxygen for oxygen-iodine laser"SPIE. Vol.4184. 32-35 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshihumi Kihara: "Experimental study of the oscillation in discharge oxygen-iodine laser"RESEARCH REPORTS OF ANAN NATIONAL COLLEGE OF TECHNOLOGY. No.37. 67-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo.Fujii: "Radio-frequency plasma jet generation of singlet oxygen with high yield"Applied Physics Letters. Volume 78, Issue 18. 2649-2651 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo.Fujii: "Singlet Oxygen Generator for a Discharge Pumped Oxygen-Iodine Laser"The Review of Laser Engineering. Vol.29. 605-609 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro.Hashimoto: "First Cutaneous Branch of the Internal Pudendal Artery : An Anatomical Basis for the So-called Gluteal Fold Flap"Okajimas Folia Anatomica Japonica. Vol.78, No.l. 23-30 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Hashimoto: "The Gluteal-Fold Flap for Vulvar and Buttock Reconstruction: Anatomic Study and Adjustment of Flap Volume"Plastic and Reconstructive Surgery. Vol.108, No.7. 1998-2005 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro.Hashimoto: "Angiostatic effects of corticosteroid on wound healing of the rabbit ear"The Journal of Medical Investigation. Vol.49, No.1,2. 61-66 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo.Fujii: "RF plasma jet generation of singlet delta oxygen in chilled and energy transfer modes for oxygen iodine laser"SPIE (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Hashimoto: "The Features of Thrombus in a Mierovessel Injury Model and the Antithrombotic Efficacy of Heparin, Urokinase, and Prostaglandin El"Plastic and Reconstructive Surgery. (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroo Fujii: "RF plasma jet generation of singlet delta oxygen in chilled and energy transfer modes for oxygen iodine laser"SPIE. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ichiro Hashimoto: "The Features of Thrombus in a Mierovessel Injury Model and the Antithrombotic Efficeacy of Heparin, Urokinase, and Prostaglandin El"Plastic and Reconstructive Surgery. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ichiro Hashimoto: "Angiostatic effects of corticosteroid on wound healing of the rabbir ear"The Journal of Medical Investigation. 49,1-2. 61-66 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroo Fujii: "Radio-frequency plasma jet generator of singlet delta oxygen with high yield"Applied Physics Letters. Vo178,No18. 2649-2651 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 藤井洋郎: "放電励起酸素ヨウ素レーザーに用いる励起酸素発生器"レーザー研究. Vo129,No9. 605-609 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 木原義文: "放電式ヨウ素レーザ用励起酸素発生器の性能試験"信学技報レポート. MBE2001-57. 31-35 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ichiro Hashimoto: "First cutaneous branch of the first pudendal artery : An anatomical basis for the so-called gluteal fold flap"Okajima Folia Anatomica Japonica. Vo178,No1. 23-30 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ichoro Hashimoto: "The Gluteal Fold Flap for Vulvar and Buttock Reconstruction : Anatomical Study and Adjustment of Flap Volume"Plastic and Reconstruction Surgery. Vol108,No7. 1998-2005 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiroo Fujii: "Hybrid oxygen iodine laser with a discharge singlet oxygen generator"SPIE. Vol.4065. 818-825 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Josef Schmiedberger: "RF Plasma Jet Generation of Singlet Delta Oxygen for Oxygen Iodine Laser"SPIE. Vol.4184. 32-35 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 木原義文: "放電式ヨウ素レーザの発振実験"研究紀要(阿南高専). 37号. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 藤井洋郎: "医療応用を目的とした新型近赤外レーザシステムの開発"STEPテクノ情報誌. 7巻1号. 8-9 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 原田浩史: "糖尿病における皮膚微小循環障害"日本形成外科学会誌. 20号. 258-264 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ichiro Hashimoto: "The Gluteal Fold Flap for Vulvar and Buttock Reconstruction"Plastic and Reconstruction Surgery. (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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