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Development of auditory brainstem implant

Research Project

Project/Area Number 12555068
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAO Masayuki (2001-2002)  The University of Tokyo, Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (90242007)

畑村 洋太郎 (2000)  東京大学, 大学院・工学系研究科, 教授 (40010863)

Co-Investigator(Kenkyū-buntansha) KAGA Kimitaka  The University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (80082238)
MATSUMOTO Kiyoshi  The University of Tokyo, Graduate School of Information Science and Technology, Assoc. Professor, 大学院・工学系研究科, 助教授 (10282675)
HATAMURA Yotaro  Kogakuin University, Dep. of Basic Engineering in Global Environment, Professor, 国際基礎工学科, 教授 (40010863)
中尾 政之  東京大学, 大学院・工学系研究科, 助教授 (90242007)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2000: ¥8,300,000 (Direct Cost: ¥8,300,000)
KeywordsAuditory brainstem implant / Microelectrode array / Evoked potential / Electorical stimulation / Cochlear nucleus / Auditory cortex / Functional mapping of brain / Neural model / 機能構造 / 脊髄 / 独立成分解析 / 表面電極 / マイクロ電極 / ABR / MLR
Research Abstract

This project purposes to establish design methodology for auditory prostheses for patients having some neural impairment. We especially focused on auditory systems and accomplished following major achievements : (1) Development of an animal model for a brainstem implant system, which includes the surface microelectrode for anditory cortical recording and a spike microelectrode array for cochlear nuclear brainstem stimulation ; (2) Validation of brainstem stimulation for pitch and intensity sensation, based on investigation of auditory cortical functional organization ; and (3) Development of "the multiple gating stimulation," which can selectively activate nerves placing in between electrodes.
The surface microelectrode array epi-cortically measures high-resolution auditory cortical signals. The array employs a polyimide substrate so as to conform curved and pulsating cortical surface. The array has 70 recording points in a 2-mm-square area. The spike microelectrode array files 16 tungs … More ten microelectrodes in a grid form with 400-□m spacing.
We first investigate pure-tone-evoked auditoly cortical responses and auditory cortical organizations based on the responses. The responses represent characteristic spatio-temporal patterns depending on frequency and intensity of the stimuli. The spike microelectrode array, then, stimulates the brainstem cochlear nucleus, and the evoked responses have good agreement with acoustically evoked responses. Moreover, our results strongly suggest pitch and intensity sensation is possible when an adequate position at a brainstem is stimulated at an adequate current intensity.
We demonstrate the feasibility of the gating stimulation via simulations with nerve equations and in vivo experiments of rat spinal cord stimulation. The technique broadly generates action potentials with "the cathodic source electrodes," and simultaneously blocks unnecessary propagation with "the anodic gate electrodes," resulting in selective propagation in between electrodes. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] Hirokazu Takahashi他5: "Microelectrode Array on folding polyimide ribbon for epidural mapping of functional evoked potentials"IEEE Transactions on Biomedical Engineering. 50・4. 510-516 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他5: "皮質硬膜上から高空間分解能で誘発電位を計測するための微小多点ポリイミド表面電極の開発"電気学会電子情報システム部門誌. 122-C・9. 1459-1468 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他3: "聴性誘発電位の多点計測データの独立成分解析"電気学会電子情報システム部門誌. 122-C・9. 1469-1480 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他7: "微小多点表面電極および微小剣山電極の開発とそれらを用いた聴覚機能の解明"電子情報通信学会技術研究報告. 100. 57-62 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知: "音刺激および電気刺激に対する誘発電位の多点同時計測による聴皮質の機能解明"医学のあゆみ. 200. 192-193 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi他7: "Accessing Cortical Tonotopic Organization by Microstimulation of Cochlear Nucleus"Proceedings of 1st International IEEE EMBS Conference on Neural Engineering. 161-164 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi他4: "Multiple gating stimulation for selective activation of nerves in between electrodes"Proceedings of the International Federation for Medical & Biological Engineering. 3. 786-787 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi他5: "Auditory evoked-potential mappings unravel functional organizations of rat auditory cortex ; both the primary auditory field (AI) and anterior auditory field (AAF) show tonotopic organization and the latter has extreme loudness-dependence"Abstract of 3rd Forum of European Neuroscience. (CD-ROM). 184.18 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他7: "微小多点表面電極で計測した脳神経活動をウェーブレット解析で特徴抽出する試み"医用電子と生体工学. 39. 318 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他5: "微小剣山電極を用いた蝸牛神経核における局所刺激および計測"医用電子と生体工学. 39. 317 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI他8: "Surface multipoint microelectrode for direct recording of auditory evoked potentials on Auditory Cortex on a rat"Proceedings of 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine & Biology. 512-517 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI他5: "Micro multi-pointed sheet electrode for auditory brainstem implant"Proceedings of American Society for Precision Engineering 15th Annual Meeting. 349-352 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他7: "聴覚情報処理の理解とその再建"平成15年電気学会全国大会シンポジウム講演論文集. 3-S17-7 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他4: "近接電場電位のモデル解析と微小表面多点電極で計測した脳神経活動の独立成分解析"SICE2001. (CD-ROM). 110D-2 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋宏知他7: "微小多点表面電極および微小剣電極の開発とそれらを用いた脳神経活動の計測"SICE2001. (CD-ROM). 110D-1 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Takayuki Ejiri, Masayuki Nakao, Kaoya Nakamura, Kimitaka Kaga, and Thierry Herve: "Microelectrode Array on folding polyimide ribbon for epidural mapping of functional evoked potentials"IEEE Transactions on Biomedical Engineering. 50. 510-516 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Takayuki Ejiri, Masayuki Nakao, Naoya Nakamura, Kimitaka Kaga, and Thierry Herve: "Polyimide multiple-site surface microelectrode for epidural cortical recording of high spatial resolution evoked-potentials"Transaction of IEE of Japan. 122-C. 1459-1468 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Masayuki Nakao, Kimitaka Kaga, and Thierry Herve: "Independent component analysis of multiple-site auditory evoked potentials"Transaction of IEE of Japan. 122-C. 1469-1480 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Study on Auditory Pathway Functions with Surface Multipule Microelectrode and Spike Microelectrode Array"IEICE Technical Report. 100,479. 57-62 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI: "Functional Organization of Auditory Cortex Elucidated by Auditory and Electrical Evoked-potential Mapping"Journal of Clinical and Experimental Medicine. 200. 192-193 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Fumio Mase, Masayuki Nakao, Takayuki Ejiri, Tetsuji Ota, Thierry Herve, Sebastien A. Schmerber, Kimitaka Kaga: "Accessing Cotical Tonotopic Organization by Microstimulation of Cochlear Nucleus"Proceedings of 1st International IEEE EMBS Conference on Neural Engineering. 161-164 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Masayuki NAKAO, Yusuke YASUDA, Sheykholeslami KIANOUSHI, and Kimitaka KAGA: "Multiple gating stimulation for selective activation of nerves in between electrodes"Proceedings of the International Federation for Medical & Biological Engineering (2nd European Medical & Biological Engineering Conference). 3. 786-787 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Naoya NAKAMURA, Thierry HERVE, and Kimitaka KAGA: "Auditory evoked-potential mappings unravel functional organizations of rat auditory cortex, both the primary auditory field (AI) and anterior auditory field (AAF) show tonotopic organization and the latter has extreme loudness-dependence(CD-ROM)"Abstract of 3rd Forum of European Neuroscience. #184.18. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Fumio MASE, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Wavelet Analysis for Feature Extraction of Spatio-temporal Neuronal Data Acquired with the Surface Microelectrode"Proceedings of the 40^<th> Conference of the Japan Society of Medical Electronics & Biological Engineering. 39(Suppl.). 318 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Fumio MASE, Masayuki NAKAO, Takayuki EJIRI, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Microelectrode Array for Local Stimulation and Measurement of Neuronal Activity at Cochlear Nucleus"Proceedings of the 40^<th> Confenence of the Japan Society of Medicai Electronics & Biological Engineering. 39(Suppl.). 317 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Fumio MASE, Kiyoshi MATUMOTO, Yotaro HATAMURA, Naoya NAKAMURA, Thierry HERVE, and Kimitaka KAGA: "Surface multipoint microelectrode for direct recording of auditory evoked potentials on Auditory Cortex on a rat"Proceeding of 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine & Biology. 512-517 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Kiyoshi MATUMOTO, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, and Thierry HERVE: "Micro multi-pointed sheet electrode for auditory brainstem implant"Proceedings of American Society for Precision Engineering 15th Annual Meeting. 349-352 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHl, Masayuki NAKAO, Fumio MASE, Takayuki EJIRI, Tetsuji OTA, Thierry HERVE, Sebastien SCHIMERBER, Kimitaka KAGA: "Understanding and Restoring Auditory Signal Processing"2003 National Convention Record IEE Japan. #3-S17-7. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Masayuki NAKAO, Yotaro HATAMURA, Kimitaka KAGA, Thierry HERVE: "Model Analysis of Near Field Potential and Independent Component Analysis of Spatio-temporal Cortical Data Acquired with the Surface Microelectrode (CD-ROM)"Proceedings of SICE 2001. 110D-1. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Fumio MASE, Masayuki NAKAO, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Surface Microelectrode and Spike Microelectrode Array for Measuring Neuronal Activities (CD-ROM)"Proceeding of SICE 2001. 110D-2. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, 他5: "Multiple-site polyimide surface microelectrode with fold-structure for less-invasive epidural cortical mapping of functional evoked-potentials"IEEE Transactions on Biomedical Engineering. 50・4(印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋宏知, 他5: "皮質硬膜上から高空間分解能で誘発電位を計測するための微小多点ポリイミド表面電極の開発"電気学会電子情報システム部門誌. 122-C・9. 1459-1468 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋宏知, 他3: "聴性誘発電位の多点計測データの独立成分解析"電気学会電子情報システム部門誌. 122-C・9. 1469-1480 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他4: "Multiple gating stimulation for selective activation of nerves in between electrodes"Proceedings of the International Federation for Medical & Biological Engineering. 3. 786-787 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他7: "Accessing Cortical Tonotopic Organization by Microstimulation of Cochlear Nucleus"Proceedings of 1st International IEEE EMBS Conference on Neural Engineering. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他5: "Auditory evoked-potential mappings unravel functional organizations of rat auditory cortex; both the primary auditory field (AI) and anterior auditory field (AAF) show tonotopic organization and the latter has extreme loudness-dependence"Abstract of 3rd Forum of European Neuroscience. (CD-ROM). 184.18 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋宏知: "音刺激および電気刺激に対する誘発電位の多点同時計測による聴皮質の機能解明"医学のあゆみ. 200・2. 192-193 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極と微小剣山電極の開発とそれらを用いた脳神経系活動の計測"SICE2001(第40回計測自動制御学会学術講演会)講演論文集. (CD-ROM). 110D-112D (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他4名: "近接電場電位のモデル解析と微小表面多点電極で計測した脳神経活動の独立成分解析"SICE2001(第40回計測自動制御学会学術講演会)講演論文集. (CD-ROM). 110D-111D (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極で計測した脳神経活動の独立成分分析法による解析"医用電子と生体工学. 39(特別号). 316 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小剣山電極を用いた蝸牛神経核における局所刺激および計測"医用電子と生体工学. 39(特別号). 317 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極で計測した脳神経活動をウェーブレット解析で特徴抽出する試み"医用電子と生体工学. 39(特別号). 318 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知 他: "口腔内原音発生振動子を用いた無咽頭者の発声システムの開発とそれの代用原音を口腔内圧で制御する試み"音声言語医学. Vol.41 No.2. 130-138 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Takahashi, et.al.: "Micro Multi-point Sheet Electrode for Auditory Brainstem Implant"Proc.of ASPE'00. 349-352 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Takahashi, et.al.: "Surface Multipoint Microelectrode for Direct Recording of Auditory Evoked Potentials on the Auditory Cortex or a Rat"Proc.of IEEE-EMGS in Microtechnologies in Medicine & Biology. 512-517 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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