| Project/Area Number |
12555256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIMURA Shin-ichiro Hokkaido Univ., Grad. School of Science., Prof., 大学院・理学研究科, 教授 (00183898)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Yoshinobu Chemical Biology Institute, Inc. Chief Research Coordinator, 主席研究員
KONDO Hirosato Shionogi & Co., LTD General Manager, 部長
NISHIMURA Takashi Hokkaido Univ., Institute for Generic Medicine., Prof., 遺伝子病制御研究所, 教授 (30143001)
前川 宣彦 株式会社 生物有機化学研究所, 主幹研究員
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2002: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | glycopeptide / glycosyltransferase / cyclic glycopeptide / influenza virus / cell adhesion / antifreeze glycoprotein / 癌転移 / 糖転移酵素 / インフルエンザ / ヘマグルチニン / ヘマグルチニンブロッカー / 環状ペプチド / 計算化学 / 自動合成装置 / 細胞接着 / RGDS / SLe^x / リンパ球 / 血管内皮細胞 / 抗アレルギー剤 / シアリルルイスx / RGDS配例 / ヘテロバイファンクショナル / 抗炎症剤 / 抗ガン剤 / Chemoenzymatic / ハイブリッド |
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| Research Abstract |
Molecular design and syntheses of the novel type of glycopeptides were carried out in order to create therapentic reagents in cellular adhesion diseases such as cancer, viral infection, and inflammatory.
Efficient and versatile synthetic schemes were established by means of combined chemical and enzymatic procedures.
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