| Project/Area Number |
12557035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAMURA Hiroyuki Kanazawa University Graduate School of Medical Science, Associate professor, 医学系研究科, 助教授 (30231476)
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| Co-Investigator(Kenkyū-buntansha) |
OGINO Keiki Kanazawa University Graduate School of Medical Science, Professor, 医学系研究科, 教授 (70204104)
NAGASE Hirofumi Kanazawa University Graduate School of Medical Science, Assistant professor, 医学系研究科, 講師 (00251918)
中島 円 金沢大学, 医学部, 助手 (10324071)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2000: ¥10,700,000 (Direct Cost: ¥10,700,000)
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| Keywords | microwaves / prostagiandin / uteroplacental blood flow / pregnancy / progesterone / heat / SAR / immunity / 物理的環境刺激 / 電界 / 磁界 |
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| Research Abstract |
We developed microwave device simulating actual environmental exposure of very low level with changing frequencies produced by recent communicating instruments. The field was generated by signal simulation of the Global System for Mobile communications (GSM) of 960 MHz. Subjects were exposed in a specially constructed chamber, a Transverse Electromagnetic (TEM) cell. The Specific Absorption Rate (SAR) value for each cell well was calculated for this exposure system. Microwaves of 2 and 10 mW/cm^2 elevated 0.98±0.12, 3.70±0.15℃ (Mean±SE) , respectively, of rectal temperature hi rats after continuous exposure of 90 min, and 0.22±0.19, 1.69±0.20℃, respectively after 180 min. Heat during microwaves produce uteroplacental circulatory disturbances, "subsequently causing abortion. The decreases in uteroplacental blood flow accompanying microwaves of 2 and 10 mW/cm^2 were reversible and irreversible changes, respectively. Pretreatment with progesterone receptor antagonist mifepristone produced irreversible change during microwaves of 2 mW/cm^2 with a simultaneous decrease in Prostaglandin (PG)E_2, but not changed NK cell activity. Therefore, the irreversible decrease in uteroplacental blood flow seems to be due to the actions of progesterone and PGE_2.in cooperation with cellular immune function. The homeostasis of endocrine-immune system is important to prevent pregnancy from effects of ultra low level microwaves with changing frequencies.
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