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Induction of differentiation of monkey embryonic stem cells into tissue-specific functional cells

Research Project

Project/Area Number 12557067
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

TSUJI Kohichiro  The Institute of Medical Science, The University of Tokyo, Associate Professor, 医科学研究所, 助教授 (50179991)

Co-Investigator(Kenkyū-buntansha) TANAKA Ryuhei  Biology Division, National Cancer Center, Research Institute, Section Head (Researcher), 生物学部, 室長(研究職) (80322072)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2001: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2000: ¥7,800,000 (Direct Cost: ¥7,800,000)
Keywordsmonkey embryonic stem cells / AGM region / stromal cells / NOD / SCID mice / 造血幹細胞 / ストローマ
Research Abstract

1. Characterization of rhesus embryonic stem (rES) cells
rES cells were maintained by the coculture with mouse embryonic fibroblasts. The maintained rES cells expressed alkaliphaphatase, SSEA1 and SSEA4. When the rES cells were transplanted into NOD/SCID mice through the tail vain, they produced teratoma in the recipient's lung. These results indicate the immature nature of rES cells.
2. Differentiation of rES cells
When the rES cells were cocultured with stromal cells derived from aorta-gonad-mesonephros (AGM) region in 10.5 days postcoitum (dpc) mouse embryo, they formed cobble stone areas, which generated small round cells after 2 weeks of coculture. Flowcytometric analysis showed that a part of the generated cells expressed human CD34. We are further characterizing the cells expressing human CD34.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (97 results)

All Other

All Publications (97 results)

  • [Publications] Matsui A: "gp130 and c-kit signals synergistically induce thrombopoietin production by hematopoietic cells"Int J Hematol. 72. 455-462 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuoka S: "CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages"Blood. 97. 419-425 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi T: "Surface protein D and KL-6 as serological indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia"J Med. 32. 41-51 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Xu M: "Evidence for the presence of primitive megakaryopoiesis in the early yolk sac"Blood. 97. 2016-2022 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshimasu T: "Prompt and durable hematopoietic reconstitution by an unrelated cord blood transplantation in a child with Fanconi anemia"Bone Marrow Transplant. 27. 767-769 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ma F: "Development of human lymphohematopoietic stem/progenitor cells defined by CD34 and CD81 expressions"Blood. 97. 3755-3762 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miyamoto K: "Inhibitory effect of interleukin-3 on the early development of human B-lymphopoiesis"Br J Haematol. 114. 690-697 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hisakawa H: "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryo expressing hGM-CSF receptors but not erythropoietin"Blood. 98. 3618-3625 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuji K: "Expression of G-CSF receptor on myeloid progenitors"Leukemia & Lymphoma. 42. 1351-1357 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ma F: "Growth of human T-cell acute lymphoblastic leukemia lymphoblasts in NOD/SCID fetal thymus organ culture : a possible role of the expression of IL-7 receptor in the proliferation of T-lymphoid leukemic cells"Leukemia. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "Blackfan-Diamond症候群"小児科診療. 64. 188 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "試験管内造血幹細胞増幅"現代医療. 33. 2011-2015 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "造血幹細胞コロニー刺激因子と臍帯血造血幹細胞の体外増幅"日本産婦人科・新生児血液学会誌. 10. 33-36 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 浅野茂隆: "ES細胞を用いた組織再生の基礎"整形・災害外科. 44. 865-869 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "造血幹細胞のex vivo増幅の現状"分子細胞療法2. 450-453 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "造血幹細胞"小児科診療. 64. 2157-2162 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "幹細胞を利用した再生医療"小児内科. 34. 37-41 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "サイトカインを用いた造血幹細胞増幅"血液・腫瘍科. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "血液細胞の再生医学"ゲノム医学. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuji K, Ueda T, Ebihara Y: "Methods in Molecular Medicine-Cytokines and Colony Stimulating Factors"Cytokine mediated expansion of human NOD/SCID-repopulating cells (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 田中竜平, 辻浩一郎: "造血器疾患治療マニュアル"浅野茂隆, 池田康夫, 内田卓編、メディカルレビュー社(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "必携造血幹細胞移植-わが国のエビデンスを中心に-"小寺良尚, 加藤俊一編、医学書院(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 辻浩一郎: "小児白血病ハンドブッック"月本一郎編、中外医学社(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsui A, Sato T, Maekawa T, Asano S, Nakahata T, Tsuji K: "gp130 and c-kit signals synergistically induce thrombopoietin production by hematopoietic cells"Int J Hematol. 72. 455-462 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuoka S, Ebihara Y, Xu M, Yoshino H, Ueda T, Manabe A, Tanaka R, Ikeda Y, Nakahata T, Tsuji K: "CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental Stages"Blood. 97. 419-425 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi T, Ebihara Y, Manabe A, Tsuji K, Nakamura T, Nakahata T, Iwamoto A: "Surface protein D and KL-6 as serological indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia"J Med. 32. 41-51 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Xu M, Matsuoka S, Yang F-C, Ebihara Y, Manabe A, Kikuchi A, Eguchi M, Asano S, Nakahata T, Tsuji K: "Evidence for the presence of primitive megakaryopoiesis in the early yolk sac"Blood. 97. 2016-2022 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshimasu, T, Tanaka R, Suenobu S, Yagasaki H, Yoshino H, Hisakawa H, Ishii T, Mitsui T, Ebihara Y, Manabe A, Nakahata T, Maekawa T, Asano S, Tsuji K: "Prompt and durable hematopoietic reconstitution by an unrelated cord blood transplantation in a child with Fanconi anemia"Bone Marrow Transplant. 27. 767-769 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ma F, Wada M, Ebihara Y, Ishii F, Manabe A, Tanaka R, Maekawa T, Ito M, Mugishima H, Asano S, Nakahata T, Tsuji K: "Development of human lymphohematopoietic stem/progenitor cells defined by CD34 and CD81 expressions"Blood. 97. 3755-3762 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda T, Yoshida M, Yoshino H, Kobayashi K, Kawahata, M, Ebihara Y, Ito M, Asano S, Nakahata T, Tsuji K: "Hematopoietic capability of cord blood CD34^+ cells : a comparison with that of adult bone marrow CD34^+ cells"Int J Hematol. 73. 457-462 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miyamoto K, Tsuji K, Maekawa T, Asano S, Nakahata T,: "Inhibitory effect of interleukin-3 on the early development of human B-lymphopoiesis"Br J Haematol. 114. 690-697 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuoka S, Tsuji K. Hisakawa H, Xu M, Ebihara Y, Ishii T, Sugiyama D, Manabe A, Tanaka R, Ikeda Y, Asano S, Nakahata T: "Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleura by aorta-gonad-mesonephros region-derived stromal cells."Blood. 98. 6-12 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hisakawa H, Sugiyama D, Nishijima I, Hong Wu, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K: "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryo expressing hGM-CSF receptors but not erythropoietin receptors"Blood. 98. 3618-3625 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuji K, Ebihara Y: "Expression of G-CSF receptor on myeloid progenitors"Leukemia & Lymphoma. 42. 1351-1357 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuji K. Ueda T, Ebihara Y: "Cytokine mediated expansion of human NOD/SCID-repopulating cells"Methods in Molecular Medicine-Cytokines and Colony Stimulating Factors, edited by Korholz D and Kiess W (The Human Press, Totowa). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ma F, Manabe A, Ito M, Kikuchi A, Wada M, Ito M, Ohara A, Hosoya R, Asano S, Tsuji K: "Growth of human T-cell acute lymphoblastic leukemia lymphoblasts in NOD/SCID fetal thymus organ culture : a possible role of the expression of IL-7 receptor in the proliferation of T-lymphoid leukemic cells"Leukemia. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuji K. Ma F: "Expression of CD81 on human hematopoietic cells"Leukemia & Lymphoma. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsui A: "gp130 and c-kit signals synergistically induce thrombopoietin production by hematopoietic cells"Int J Hematol. 72. 455-462 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuoka S: "CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages"Blood. 97. 419-425 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi T: "Surface protein D and KL-6 as serological indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia"J Med. 32. 41-51 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Xu M: "Evidence for the presence of primitive megakaryopoiesis in the early yolk sac"Blood. 97. 2016-2022 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimasu T: "Prompt and durable hematopoietic reconstitution by an unrelated cord blood transplantation in a child with Fanconi anemia"Bone Marrow Transplant. 27. 767-769 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ma F: "Development of human lymphohematopoietic stem/progenitor cells defined by CD34 and CD81 expressions"Blood. 97. 3755-3762 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Miyamoto K: "Inhibitory effect of interleukin-3 on the early development of human B-lymphopoiesis"Br J Haematol. 114. 690-697 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hisakawa H: "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryo expressing hGM-CSF receptors but not erythropoietin"Blood. 98. 3618-3625 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuji K: "Expression of G-CSF receptor on myeloid progenitors"Leukemia & Lymphoma. 42. 1351-1357 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ma F: "Growth of human T-cell acute lymphoblastic leukemia lymphoblasts in NOD/SCID fetal thymus organ culture : a possible role of the expression of IL-7 receptor in the proliferation of T-lymphoid leukemic cells"Leukemia. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "Blackfan-Diamond症候群"小児科診療. 64. 188 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "試験管内造血幹細胞増幅"現代医療. 33. 2011-2015 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "造血幹細胞コロニー刺激因子と臍帯血造血肝細胞の体外増幅"日本産婦人科・新生児血液学会誌. 10. 33-36 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 浅野茂隆: "ES細胞を用いた組織再生の基礎"整形・災害外科. 44. 865-869 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "造血肝細胞のex vivo増幅の現状"分子細胞療法2. 450-453 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "造血幹細胞"小児科診療. 64. 2157-2162 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "幹細胞を利用した再生医療"小児内科. 34. 37-41 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "サイトカインを用いた造血幹細胞増幅"血液・腫瘍科. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "血液細胞の再生医学"ゲノム医学. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuji K, Ueda T, Ebihara Y: "Methods in Molecular Medicine-Cytokines and Colony Stimulating Factors (Cytokine mediated expansion of human NOD/SCID-repopulating cells)"The Human Press (in press). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 田中竜平, 辻浩一郎: "造血器疾患治療マニュアル"浅野茂隆、池田康夫、内田卓編、メディカルレビュー社(印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "必携造血幹細胞移植-わが国のエビデンスを中心に-"小寺良尚、加藤俊一編、医学書院(印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] 辻浩一郎: "小児白血病ハンドブック"月本一郎編、中外医学社(印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Ueda T.: "Expansion of human NOD/SCID-repopulating cells by a combination of stem cell factor, Flk2/Flt3 ligand, thrombopoietin and a complex of interleukin-6 and soluble interleukin-6 receptor."J.Clin.Invest.. 105. 1013-1021 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hayashi Y.: "SN-1, a novel leukemic cell line with t(11;16)(q23;p13): myeloid characteristics and resistance to retinoids and vitamin D3."Cancer Res.. 60. 1139-1145 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ebihara Y.: "Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34^+ cells."Br.J.Haematol.. 109. 153-161 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda T.: "Hematopoietic repopulating ability of cord blood CD34^+ cells in NOD/Shi-scid mice."Stem Cells. 18. 204-213 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda T.: "Massive pericardial and pleural effusion with anasarca following allogeneic bone marrow transplantation."Int.J.Hematol.. 71. 394-397 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sato T.: "Erythroid progenitors differentiate and mature in response to endogenous erythropoietin."J.Clin.Invest.. 106. 263-270 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ishii T.: "Improvement in bronchiolitis obliterans organizing pneumonia by combination of oral predonisolone and low dose erythromycin in a child after allogegeneic bone marrow transplantation."Bone Marrow Transplant. 26. 907-910 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sugiyama H.: "Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells."FEBS Lett.. 467. 259-262 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshino H.: "Natural killer cell depletion by anti-asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid mice."Bone Marrow Transplant.. 26. 1211-1216 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takaki S.: "Control of B cell production by the adaptor protein Lnk, a negative regulator of tyrosine kinase signaling."Immunity. 13. 599-609 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsui A.: "gp130 and c-kit signals synergistically induce thrombopoietin production by hematopoietic cells."Int.J.Hematol.. 72. 455-462 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuji K.: "Expression of G-CSF receptor on myeloid progenitors."Leukemia and Lymphoma. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsuoka S.: "CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages."Blood. 97. 419-425 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ma F.: "Cytokine requirement for the development of T-lineage potential from lymphohematopoietic progenitor cells."Br,J.Haematol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Sugiyama.H.: "Peroxisome proliferator-activated receptors are expressed in human cultured mast cells : a possible role of these receptors in negative regulation of mast cell activation."Eur.J.Immunol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Xu M.: "Evidence for the presence of primitive megakaryopoiesis in the early yolk sac."Blood. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda T.: "Hematopoietic capability of cord blood CD34^+ cells : a comparison with that of adult bone marrow CD34^+ cells."Int.J.Hoematol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshimasu T.: "Prompt and durable hematopoietic reconstitution by an unrelated cord blood transplantation in a child with Fanconi anemia."Bone Marrow Transplant.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Miyamoto K.: "Inhibitory effect of interleukin-3 on the early development of human B-lymphopoiesis."Br.J.Haematol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsuoka S.: "Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleura by AGM region-derived stromal cells."Blood. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Hisakawa H.: "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryo expressing hGM-CSF receptors but not erythropoietin receptors."Blood. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ma F.: "Development of human lymphohematopoietic stem/progenitor cells defined by CD34 and CD81 expressions."Blood. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 石井武文: "急性リンパ性白血病治療後期に発症したL-アスパラギナーゼによる壊死性膵炎"日小血会誌. 14. 328-332 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岩本彰太郎: "大量rhG-CSF療法中にmonosomy7を伴うMDSに移行したKostmann症候群"日小血会誌. 14. 338-345 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 三牛哲夫: "造血幹細胞移植における支持療法と今後の課題"Biotherapy. 14. 292-300 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 辻浩一郎: "増幅造血幹細胞移植ガイドライン"分子細胞療法. 1. 197-201 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 海老原康博: "造血幹細胞の同定検査 2)コロニー法"検査と技術. 28. 971-972 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 辻浩一郎: "造血幹細胞の起源と性状"医学のあゆみ. 194. 1021-1025 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 杉山大介: "AGM領域"分子細胞療法. 1. 92-93 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 辻浩一郎: "造血幹細胞の増幅"血液・免疫・腫瘍. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 辻浩一郎: "試験管内造血幹細胞増幅"現代医療. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 辻浩一郎: "造血幹細胞コロニー刺激因子と臍帯血造血幹細胞の体外増幅"日本産婦人科・新生児血液学会. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakahata T.: "Cell Therapy"Springer-Verlag, Tokyo. 2 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakahata T.: "Mast Cell Biology"Academic Press (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuji K.: "Methods in Molecular Medicine-Cytokines and Colony Stimulating Factors"The Human Press (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 田中竜平: "造血器疾患治療マニュアル"メディカルレビュー社(大阪)(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 辻浩一郎: "小児の症候群"診断と治療社(東京)(印刷中).

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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