| Project/Area Number |
12557070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Dermatology
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| Research Institution | OSAKA UNIVERSITY |
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Principal Investigator |
TAKEDA Junji COLLABORATIVE RESEARCH CENTER FOR ADVANCED SCIENCE AND TECHNOLOGY, PROFESSOR, 先端科学技術共同研究センター, 教授 (50163407)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Shintaro BASIC RESEARCH ALBORATORY, KANEBO. LTD.. MANAGER & SENIOR SCIENTIST, 研究グループ長(研究職)
TOJO Hiromasa GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 助教授 (90135707)
井上 伸太郎 鐘紡基礎科学研究所, 研究グループ長(研究職)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2002: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2000: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | Conditional gen targeting / Cre / loxP / Stat3 / Bcl-xL / Arnt / Pten / トランスジェニックマウス / ARNT遺伝子 / LCB2遺伝 / Tリンパ球 |
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| Research Abstract |
We generated several skin specific gene-disrupted mice.
1. Stat3-deficient mice.
UV irradiation caused severe apoptosis in stat3-deficient skin.
2. Bcl-xL deficient mice.
We found in vivo cooperation between Bcl-xL and PI3K to prevent apoptosis in the skin.
3. Arnt deficient mice.
We found that regulation of ceramide compositions by Arnt is crucial for maintaining epidermal barrier function.
4. Pten deficient mice.
We found that Pten play an essential role for skin tumorigenesis.
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