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Immunotherapy using cytotoxic T cell and peptide vaccine for pancreatic cancer

Research Project

Project/Area Number 12557104
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

OKA Masaaki  Yamaguchi University School of Medicine, Professor, 医学部, 教授 (70144946)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Kotaro  Yamaguchi University Hospital, Lecturer, 医学部附属病院, 助手 (50304481)
YOSHINO Shigefumi  Yamaguchi University School of Medicine, Lecturer, 医学部, 助手 (60294633)
HAZAMA Shoichi  Yamaguchi University Hospital, Assistant Professor, 医学部附属病院, 講師 (50253159)
YAHARA Noboru  Yamaguchi University Hospital, Lecturer, 医学部附属病院, 助手 (80346569)
上野 富雄  山口大学, 医学部・附属病院, 助手 (70284255)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2002: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2001: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥5,600,000 (Direct Cost: ¥5,600,000)
Keywordspancreatic cancer / CTL / cell therapy / cancer-related peptide / cancer vaccine therapy / dendritic cell / MUC1 / ペプチド療法
Research Abstract

(1) Fifteen patients (stage III : 4, stage Iva : 8, stage Ivb : 3) with pancreatic cancer were treated by immunotherapy using MUC1-CTL after curative resection. Only one patient had liver recurrence. One year and 2 year survival rate were 80% and 21.4%, respectively. This immunotherapy may prevent liver metastasis after surgery, but can not control local recurrence.
(2) We performed phase I study of cancer peptide vaccine therapy for HLA-02 and -24 patients with unresectable pancreatic cancer. Three mg of peptides were administered with Freund's incomplete adjuvant subcutaneously. No sever adverse effect was observed. Seven of 10 patients had redness and edema in the injection sites. Three of 10 patients had NC and 7 had PD. One NC patient is still alive for 12 month. This vaccine therapy may be effective to control local lesion including regional lymph node metastasis.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Suzuki N, Tanaka S, Hida N, Yamamoto K, Oka M, Itoh K: "Detection of peptide-specific cytotoxic T lymphocyte precursors used for specific immunotherapy for pancreatic cancer"International Journal of Cancer. 98. 4894-4898 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto K, Yahara N, Gondo T, Ishihara T, Oka M: "Establishment and Characterization of a new pancreatic cancer cell line, YPK-1"The Bullitin of the Yamaguchi Medical School. 49(1-2). 33-42 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki K, Sato K, Akiyama Y, Oka M, Yamaguchi K: "Peptidomics-based Approach Reveals the Secretion of the 29-Residue COOH-Terminal Fragment of the Putative Tumor Suppressor Protein DMBT1 from Pancreatic Adenocarcinoma Cell Lines"Cancer Research. 62. 4894-4898 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okayama N, Hazama S, Oka M, Nohara H, Kayano K, Okita K, Hinoda Y: "Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor-4 gene that is associated with lipoplysaccharide hyporesponsiveness"J Clinical Laboratory analysis. 16. 56-58 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iizuka N, Oka M, et al.: "Use of oligonucleotide microarray as a novel approach for prediction of early intrahepatic recurrence in hepatocellular carcinoma after curative resection"Lancet. 361. 923-929 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yahara N, Abe T, Morita K, Tangoku A, Oka M: "Comparison of interleukin-6, interleukin-8, and granulocyte colony-stimulating factor production by the peritoneum in laparoscopic and open surgery"Surgical Endoscopy. 16. 1615-1619 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimura K, Hazama S, Iizuka N, Yoshino S, Yamamoto K, Noma T, Oka M: "Successful immunogene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature interleukin-18 cDNA and the Igkappa leader sequence"Cancer Gene Therapy. 8. 9-16 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshino S, Hazama S, Iizuka N, Yamamoto K, Oka M: "Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers"Anticancer Research. 20. 4707-4711 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka A, Ueno T, Oka M, Suzuki T: "Effect of denervation of the pylorus and transection of the duodenum on acetaminophen absorption in rats ; possible mechanism for early delayed gastric emptying after pylorus preserving pancreatoduodenectomy"Tohoku J Experimental Medicine. 192. 239-247 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohno R, Oka M, et al.: "A dose-escalation and pharmacokinetic study of subcutaneously administered recombinant human interleukin 12 and its biological effects in Jananese patients with advanced malignancies"Clinical Cancer Research. 6. 2661-2669 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 上野富雄, 岡 正朗: "膵脾外科の要点と盲点 幽門輪温存温存膵頭十二指腸切除術-Billroth I法方式膵腸吻合-"木村 理,文光堂. 343(130-133) (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki N, Tanaka S, Hida N, Mine T, Yamamoto K, Oka M, Itoh K: "Detection of peptide-specific cytotoxic T lymphocyte precursors used for specific immunotherapy for pancreatic cancer"International Journal of Cancer. Mar 1 ; 98(1). 45-50 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto K, Yahara N, Gondo T, Ishihara T, Oka M: "Establishment and Characterization of a new pancreatic cancer cell line, YPK-1"The Bulletin of the Yamaguchi Medical School. 49(1-2). 33-42 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki K, Sato K, Akiyama Y, Oka M, Yamaguchi K: "Peptidomics-based Approach Reveals the Secretion of the 29-Residue COOH-Terminal Fragment of the Putative Tumor Suppressor Protein DMBT1 from Pancreatic Adenocarcinoma Cell Lines"Cancer Research. 62. 4894-4898 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okayama N, Hazama S, Oka M, Nohara H, Kayano K, Okita K, Hinoda Y: "Simple genotype analysis of the Asp299Gly polymorphism of the Tolll-like receptor-4 gene that is associated with lipoplysaccharide hyporesponsiveness"J Clinical Laboratory analysis. 16. 56-58 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iizuka N, Oka M, et al.: "Use of oligonucleotide microarray as a novel approach for prediction of early intrahepatic recurrence in hepatocellular carcinoma after curative resection"Lancet. 361. 923-929 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yahara N, Abe T, Morita K, Tangoku A, Oka M: "Comparison of interleukin-6, interleukin-8, and granulocyte colony-stimulating factor production by the peritoneum in laparoscopic and open surgery"Surgical Endoscopy. 16. 1615-1619 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimura K, Hazama S, Iizuka N, Yoshino S, Yamamoto K, Muraguchi M, Ohmoto Y, Noma T, Oka M: "Successful immunogene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature interleukin-18 cDNA and the Igkappa leader sequence"Cancer Gene Therapy. 8. 9-16 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshino S, Tabata T, Hazama S, Iizuka N, Yamamoto K, Hirayama M, Tangoku A, Oka M: "Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers"Anticancer Research. 20. 4707-4711 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka A, Ueno T, Oka M, Suzuki T: "Effect of denervation of the pylorus and transection of the duodenum on acetaminophen absorption in rats ; possible mechanism for early delayed gastric emptying after pylorus preserving pancreatoduodenectomy"Tohoku J Experimental Medicine. 192. 239-247 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohno R, Yamaguchi Y, Toge T, Kinouchi T, Kotake T, Shibata M, Kiyohara Y, Ikeda S, Fukui I, Gohchi A, Sugiyama Y, Saji S, Hazama S, Oka M, Ohnishi K, Ohhashi Y, Tsukagoshi S, Taguchi T: "A dose-escalation and pharmacokinetic study of subcutaneously administered recombinant human interleukin 12 and its biological effects in Japanese patients with advanced malignancies"Clinical Cancer Research. 6. 2661-2669 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki N, Tanaka S, Hida N, Mine T, Yamamoto K, Oka M, Itoh K: "Detection of peptide-specific cytotoxic T lymphocyte precursors used for specific immunotherapy for pancreatic cancer"International Journal of Cancer. 98. 4894-4898 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamamoto K, Yahara N, Gondo T, Ishihara T, Oka M: "Establishment and Characterization of a new pancreatic cancer cell line, YPK-1"The Bullitin of the Yamaguchi Medical School. 49(1-2). 33-42 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasaki K, Sato K, Akiyama Y, Oka M, Yamaguchi K: "Peptidomics-based Approach Reveals the Secretion of the 29-Residue COOH-Terminal Fragment of the Putative Tumor Suppressor Protein DMBT1 from Pancreatic Adenocarcinoma Cell Lines"Cancer Research. 62. 4894-4898 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Okayama N, Hazama S, Oka M, Nohara H, Kayano K, Okita K, Hinoda Y: "Simple genotype analysis of the Asp 299Gly polymorphism of the Tolll-like receptor-4 gene that is associated with lipoplysaccharide hyporesponsiveness"J Clinical Laboratory analysis. 16. 56-58 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iizuka N, Oka M, et al.: "Use of oligonucleotide microarray as a novel approach for prediction of early intrahepatic recurrence in hepatocellular carcinoma after curative resection"Lancet. 361. 923-929 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki N: "Detection of peptide-specific cytotoxic T lymphocyte precursors used for specific immunotherapy for pancreatic cancer"International Journal of Cancer. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Yahara N: "MUC1-CTL therapy for pancreatic cancer with curative resection"Surgery. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimura K: "Successful immuno-gene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature-interleukin-18 cDNA and the Ig-Kappa leader sequence"Cancer Gene Therapy. 8. 9-16 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshino S: "Immunoregulatory effects of the anticancer polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers"Anticancer Research. 20. 4707-4712 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimura K: "Successful immuno-gene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature-interleukin-18 cDNA and the Ig-Kappa leader sequent."Cancer Gene Therapy,. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshino S: "Immunoregulatory effects of the anticancer polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers."Anticancer Research,. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohno R: "A dose-escalation and pharmacokinetic study of subcutaneously administered recombinant human interleukin 12 and its biological effects in Japanese patients with advanced malignancies."Clinical Cancer Research. 6. 2661-2669 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mori K: "Expression levels of thymidine phophorylase and dehydropyrimidine dehydrogenase in various human tumor tissues."Int J Oncol. 17(1). 33-38 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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