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New therapy combined with immunology, molecular biology and medical technology for patients with peritoneal carcinosis

Research Project

Project/Area Number 12557106
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Digestive surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

KATANO Mitsuo  Graduate School of Medical Sciences, Kyushu University, Prof., 大学院・医学研究院, 教授 (10145203)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Akihiko  Faculty of Medicine University Hospital, Kyushu University, Ass., 医学部・附属病院, 助手 (20294936)
MORISAKI Takashi  Graduate School of Medical Sciences, Kyushu University, Ass., 大学院・医学研究院, 助手 (90291517)
SUEISHI Katsuo  Graduate School of Medical Sciences, Kyushu University, Prof., 大学院・医学研究院, 教授 (70108710)
MATSUDA Takehisa  Graduate School of Medical Sciences, Kyushu University, Prof., 大学院・医学研究院, 教授 (60142189)
TANAKA Masao  Graduate School of Medical Sciences, Kyushu University, Prof., 大学院・医学研究院, 教授 (30163570)
桟敷 俊信  九州大学, 大学院・医学研究院, 助手 (20315089)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2001: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥9,200,000 (Direct Cost: ¥9,200,000)
Keywordsartificial peritoneum / artificial connective tissue / artificial carcinoma tissue / artificial immyne organ / peritoneal carcinosis / immunotherapy / reconstruction therapy of immune surveillance system / 人工リンパ節 / 腹膜播種モデル / 人工免疫産生装置 / 人工血管 / 移植 / IFN-γ
Research Abstract

This study was focused on the development of new therapeutic strategy combined with immunology, molecular biology, and medical technology for poor prognostic patients with peritoneal carcinosis. Data obtained for duration of this study are as follows :
(1) In order to develop new therapy and elucidate biological characteristics of peritoneal carcinosis, artificial tissues such as peritoneum, connective tissue, and lymphnodes were developed using various types of cells obtained from surgically resected specimens.
(2) Using these developed artificial tissues, artificial carcinoma tissue similar to human scirrhous type-gastric carcinoma tissue was newly developed. In addition, a possible new therapeutic strategy for scirrhous carcinoma of the stomach, i.e., interferon-gamma therapy, was developed using this artificial carcinoma tissue.
(3) New model of peritoneal carcinosis was developed using artificial peritoneum. New immunotherapy which is called "reconstruction therapy of immune surveillance system", for peritoneal carcinosis was developed using this new model.
(4) Phase I study (19 patients) of "reconstruction therapy of immune surveillance system based on peripheral blood stem cell transplantation and dendritic cell (DC) vaccine for patients with pleural and peritoneal carcinosis" was almost completed.
Experiments planned originally were not completely carried out. However, we newly developed several artificial tissues, including peritoneum, connective tissue, lymphnode, and carcinoma tissue, and we established new therapeutic strategies which are called "interferon-gamma therapy" and "reconstruction therapy of immune surveillance system". Especially, clinical application of "reconstruction therapy of immune surveillance system for patients with peritoneal carcinosis" started.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Kojima M. et al.: "Lipoplysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-kB activation"Oncogene. 19. 1225-1231 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato N.et al.: "Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential"Cancer Letter. 155. 153-161 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Egashira K. et al.: "Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis"FASEB Journal. 14. 1974-1978 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kitamoto S. et al.: "Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats"Circulation. 102. 806-812 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morisaki T. et al.: "A combination of cyclosporin-A (CsA) and interferon-gamma (INF-g) induces apoptosis in human gastric carcinoma"Anticancer Research. 20. 3363-3374 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamura K. et al.: "Morphometric analysis of regional lymph nodes with and without metastasis from early gastric carcinoma"Cancer. 88. 2438-2442 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Beppu K. et al.: "Hepatocyte growth factor production by peripheral blood mononuclear cells of recurrent cancer patients"Anticancer Research. 21. 2195-2200 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kuwahara A. et al.: "Expression of melanoma antigen-encoding gene-1 predicts lymph node involvement in early gastric carcinomas"Digestive Diseases and Sciences. 46. 262-267 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kojima M. et al.: "Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas"Annals of Surgical Oncology. 8. 458-465 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sasaki N. et al.: "Nuclear factor kappa B/p65(RelA) is constitutive activation in human gastric carcinoma"Clinical Cancer Research. 7. 4136-4142 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato N.et al.: "Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion"Cancer. 91. 496-504 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato N.et al.: "Instability of chromosome 8 as an indicator of aggressive tumor phenotype in pancreatic cancer"Journal of Surgical Oncology. 76. 181-187 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maehara N. et al.: "NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells"British Journal of Cancer. 84. 864-873 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 片野光男: "胸腹腔内免疫監視機構システムの再構築による癌性胸腹膜炎治療"がん集学的治療研究財団 第21回一般研究助成研究報告書. 46.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 片野光男: "人工ハイブリッド免疫装置の開発と癌病態治療への応用"W'Waves(日本癌病態治療研究会誌). 7. 86-89 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hashizume K. et al.: "Candidate host marker for peritoneal dissemination"Anticancer Research. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onishi H. et al.: "A large quantity of CD3-/CD19-/CD16-lymphocytes in malignant pleural effusion from a patient with recurrent cholangio cell carcinoma"Immunological Investigation. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 森崎 隆: "専門医のための消化器外科レビュー2000"総合医学社. 236 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 片野光男, 仁尾義則: "外科医のための癌免疫療法の理論と実際"ライフサイエンス・メディカ. 139 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kojima M, Morisaki T, Izuhara K, Uchiyama A, Matsunari Y, Katano M, Tanaka M: "Lipopolysaccharide increases cyclo oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-kB activation"Oncogene. 19. 1225-1231 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato N, Mizumoto K, Beppu K, Maehara N, Kusumoto M, Nabae T, Morisaki T, Katano M, Tanaka M: "Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential"Cancer Letters. 155. 153-161 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Egashira K, Koyanagi M, Kitamoto S, Ni W, Kataoka C, Morishita R, Kaneda Y, Akiyama C, Nishida K, Sueishi K, Takeshita A: "Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats : blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis"FASEB Journal. 14 (3). 1974-1978 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kitamoto S, Egashira K, Kitaoka C, Koyanagi M, Katoh M, Shimokawa H, Morishita R, Kaneda Y, Sueishi K, Takeshita A: "Increased activity of nuclear factor-k B participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats"Circulation. 102 (7). 806-812 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morisaki T, Matsunaga H, Beppu K, Hirano K, Kanaide H, Mori A, Katano M: "A combination of cyclosporin-A (CsA) and interferon-gamma (IFN-g) induces apoptosis in human gastric carcinoma cells"Anticancer Research. 20. 3363-3374 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamura K, Morisaki T, Noshiro H, Kinukawa N, Tanaka M: "Morphometric analysis of regional lymph nodes with and without metastasis from early gastric carcinoma"Cancer. 88. 2438-2442 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Beppu K, Uchiyama A, Morisaki T, Matsumoto K, Nakamura T, Tanaka M, Katano M: "Hepatocyte growth factor production by peripheral blood mononuclear cells of recurrent cancer patients"Anticancer Research. 21. 2195-2200 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kuwahara A, Katano M, Nakamura M, Morisaki T, Miyazaki K, Fujimoto K: "Expression of melanoma antigen-encoding gene-1 predicts lymph node involvement in early gastric carcinomas"Digestive Diseases and Sciences. 46. 262-267 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onishi H: "A large quantity of CD3-/CD19-/CD16-lymphocytes in malignant pleural effusion from a patient with recurrent cholangio cell carcinoma"Immunological Investigations. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Hashizume K: "Candidate host marker for peritoneal dissemination"Anticancer Research. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuwahara A: "Expression of melanoma antigen-encoding gene-1 predicts lymph node involvement in early gastric carcinomas"Digestive Diseases and Sciences. 46. 262-267 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kojima M: "Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas"Annals of Surgical Oncology. 8. 458-465 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sasaki N: "Nuclear factor kappa B/p65(RelA) is constitutive activation in human gastric carcinoma"Clinical Cancer Research. 7. 4136-4142 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato N: "Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion"Cancer. 91. 496-504 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato N: "Instability of chromosome 8 as an indicator of aggressive tumor phenotype in pancreatic cancer"Journal of Surgical Oncology. 76. 181-187 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Maehara N: "NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells"British Journal of Cancer. 84. 864-873 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 片野光男: "胸腹腔内免疫監視機構システムの再構築による癌性胸腹膜炎治療"がん集学的治療研究財団 第21回一般研究助成研究報告書. 46(印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] 片野光男: "人工ハイブリッド免疫装置の開発と癌病態治療への応用"W'Waves(日本癌病態治療研究会誌). 7. 86-89 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Beppu K: "Hepatocyte growth factor production by peripheral blood mononuclear cells of recurrent cancer patients"Anticancer Research. 21. 2195-2200 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki: "Recombinant Sendai virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system"The FASEB Journal. 15. 1294-1296 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sonoda H: "Small-diameter compliant arterial graft prosthesis : Design concept of coaxial double tubular graft and its fabrication"Journal of Biomedical Material Research. 55. 266-276 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohya S: "Thermoresponsive artificial extracellular matrix for tissue engineering hyaluronic acid bioconjugated with poly (N-isopropylacrylamide) grafts"Biomacromolecules. 2. 856-863 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Gohda M: "Terminally alkylated heparin. 2. Potent antiproliferative agent for vascular smooth muscle cells"Biomacromolecules. 2. 1178-1183 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 片野光男: "外科領域における癌免疫療法-その理論と実際-"ライフサイエンス・メディカ. 167 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kojima M: "Lipopolysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-kB activation."Oncogene. 19. 1225-1231 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Morisaki T: "A combination of cyclosporin-A (CsA) and interferon-gamma (IFN-γ) induces apoptosis in human gastric carcinoma cells."Anticancer Research. 20. 3363-3374 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hao Z: "Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-b1 and MMPs."Clinical & Experimental Metastasis. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 片野光男: "癌性胸腹水に対するOK-432/G-CSF併用療法"Therapeutic Research. 21. 1935-1938 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 森崎隆: "癌におけるNF-kBの活性化と抗アポトーシス機構"Cancer Frontier. 2. 42-50 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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