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Presurgical evaluation of epileptic focus with MRI and magnetoencephalography (MEG) for extra-temporal lobe epilepsy surgery.

Research Project

Project/Area Number 12557115
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Cerebral neurosurgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

SHIRANE Reizo  TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学系研究科, 助教授 (30206297)

Co-Investigator(Kenkyū-buntansha) HATANAKA Keisaku  ELEKTA, ニューロマグプロジェクト, 課長(研究職)
JOKURA Hidefumi  TOHOKU UNIVERSITY, UNIVERSITY HOSPITAL, RESEARCH ASSOCIATE, 医学部・付属病院, 助手 (30280879)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 2001: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 2000: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsEPILEPSY SURGERY / MAGNETOENCEPHALOGRAPHY / FUNCTIONAL BRAIN MAPPING / NEURONAVIGATION / 機能的MRI
Research Abstract

(1) The development of MEG analysis for intractable epilepsy patients
Interictal spike discharge was analyzed during the period from the early slope to the spike peak. The present analysis of the interictal MEG spikes enabled us to estimate epileptic focus, and predicted post-surgical seizure outcomes for extra-temporal lobe epilepsy patient.
(2) Cortical mapping with functional MRI, as presurgical evaluation for epilepsy surgery
The introduction of visual image processing system and new software made it possible to perform the accurate functional brain mapping, such as language, and visual perception.
(3) Confirmation of the accuracy of presurgical evaluation with MRI and MEG for epilepsy patients.
The introductions of digital EEG workstation enabled us to exam electro-corticograms, and perform the direct cortical stimulation with chronic subdural grids. The comparison between presurgical evaluations and grids examinations confirmed the usefulness of MEG and MRI for epilepsy surgery.
(4)Clinical applications of both MEG and MRI results.
In the present study, both MEG and MRI data were put into the system workstation, and convert to the 3D reconstruction images for intra-operative neuronavigation.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] Ishitobi Mamiko: "Remote discharges in the posterior language area during basal temporal stimulation"NeuroReport. 11. 2997-3000 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kumabe Toshihiro: "Primary thumb sensory cortex located at the lateral shoulder of the inverted omega-shape on the axial images of the central sulcus"Neurol Med Chir (Tokyo). 40. 393-403 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakasato Nobukazu: "Somatosensory, auditory and visual evoked magnetic fields in patients with brain disease"J. Clin Neurophisiol. 17. 201-211 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "てんかん棘波の脳磁図解析と術後の発作予後"脳神経外科ジャーナル. 9. 477-482 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 菅野彰剛: "脳磁図を用いた聴覚誘発磁界中潜時成分・長潜時成分の比較"マグネティックス研究会資料. MAG-00-90. 23-28 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 永松謙一: "MEGで発作間歇時棘波の側頭葉内伝播をとらえた皮質形成異常の一例"日本生体磁気学会誌. 13. 242-243 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "脳磁図(MEG)"MEDICO. 31. 154-156 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 菅野彰剛: "脳磁図入門"Medical Technology. 28. 309-315 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "MEGとfMRIによるてんかん脳の機能検査"Brain Medical. 12. 381-388 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 隈部俊宏: "運動領野周辺神経膠腫に対する手術-術前解剖学的および機能マッピングの融合とNeuronavigation systemおよび術中マッピング併用"脳神経外科ジャーナル. 10. 56-64 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 隈部俊宏: "術前ブレインマッピング"Clinical Neuroscience. 19. 310-312 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "てんかんの機能画像診断"画像診断. 21. 182-190 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaki Iwasaki: "Somatosensory evoked fields in comatose survivors after severe traumatic brain injury"Clinical Neurophysiology. 112. 205-211 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "特集・てんかん研究-20世紀から21世紀へ-MEGとfMRIによるてんかん脳の機能検査"Brain Medical. 12(4). 39-46 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 社本 博: "脳神経外科で治療するてんかん"Brain Nursing. 17(7). 45-49 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kyoko Suzuki: "Judging semantic and episodic incongruity : a magnetoencephalographic study"Neuroreport. 12(2). 195-199 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 佐藤清貫: "術中脳表脳波を必要とするてんかん手術の麻酔管理"臨床麻酔. 25(2). 189-192 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "特集臨床ナースのための 症状から見た緊急検査値の意味 全身の症状 痙攀"臨床看護. 27(6). 736-739 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岩崎真樹: "MEGにて特異的に検出されたてんかん棘波"第16回日本生体磁気学会大会論文集. 14(1). 160-161 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 永松謙一: "口唇部電気刺激に対する脳表誘発電位と誘発磁界の比較"第16回日本生体磁気学会大会論文集. 14(1). 162-163 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 菅野彰剛: "交通外傷後遷延性意識障害患者における脳磁図発作間欠時異常波のMCE法による解析"第16回日本生体磁気学会大会論文集. 14(1). 164-165 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 畑中啓作: "MCE法によるパターンリバーサル刺激視覚誘発磁界の解析"第16回日本生体磁気学会大会論文集14(1):178-179,2001. 14(1). 178-179 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 清水宏明: "特集 functional MRIによる脳機能評価-基礎から臨床へ-functional MRIによる術前脳機能評価"脳の科学. 23. 775-782 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "側頭葉てんかん外科治療における脳磁図診断の意義"臨床脳波. 43(9). 571-576 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中里信和: "ちょこっと教えて 最先端医療 診断 脳磁図"Brain Nursing. 17(11). 67-71 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Sato: "Effect of Nitrous Oxide on Spike Activity During Epilepsy Surgery"Acta Neurochirurgica (Wien). 143. 1213-1216 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshiki Endo: "Effects of sevoflurane on electrocorticography in patients with intractable temporal lobe epilepsy"J Neurosurgical Anesthesiology. 14(1). 59-62 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyotaka Sato: "Effect of sevoflurane on electrocorticogram in normal brain"J Neurosurgical Anesthesiology. 14(1). 63-65 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 社本 博: "脳磁図と術中脳波の併用が有効であった難治性前頭葉てんかん症例"脳神経外科. 30(4)(印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iwasaki Masaki: "Surgical implications of neuromagnetic spike localization in temporal lobe epilepsy"Epilepsia. 43(In press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishitobi M, Nakasato N, Suzuki K, Nagamatsu K, Shamoto H, Yoshimoto T: "Remote discharges in the posterior language area during basal temporal stimulation."NeuroReport. 11 (13). 2997-3000 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kumabe T, Nakasato N, Inoue T, Yoshimoto T: "Primary thumb sensory cortex located at the lateral shoulder of the inverted omega-shape on the axial images of the central sulcus"Neurol Med Chir (Tokyo). 40. 393-403 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakasato N, Yoshimoto T: "Somatosensory, auditory and visual evoked magnetic fields in patients with brain disease"J Clin Neurophysiol. 17. 201-211 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iwasaki M, Nakasato N, Kanno A, Hatanaka K, Nagamatsu K, Nagamine Y, Yoshimoto T: "Somatosensory evoked fields in comatose survivors after severe traumatic brain injury"Electroencephalogr Clin Neurophyiol. 112. 205-211 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Suzuki K, Okuda J, Otsuka Y, Sugawara A, Hatanaka K, Nakasato N, Kanno A, Yoshimoto. T, Fujii A, Yamadori A: "Judging semantic and episodic incongruity: a magnetoencephalographic study"Neuroreport. 12 (2). 195-199 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato Y, Sato K , Shamoto H, Kato, T, Yoshimoto T: "Effect of Nitrous Oxide on Spike Activity During Epilepsy Surgefy"Acta Neurochirurgica (Wien). 143. 1213-1216 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Endo T, Sato K, Shamoto H, Yoshimoto T: "Effects of sevoflurane on electrocorticography in patients with intractable temporal lobe epilepsy"J Neurosurg Anesthesiol. 14. 59-62 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato K, Shamoto H, Yoshimoto T: "Effect of sevoflurane on electrocorticogram in normal brain"J Neurosurg Anesthesiol. 14. 63-65 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iwasaki M, Nakasato N, Shamoto H, Nagamatsu K, Kanno A, Hatanaka K, Yoshimoto T: "Surgical implications of neuromagnetic spike localization in temporal lobe epilepsy"Epilepsia. 43 (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakasato N, Shamoto H, Nagamatsu K, Iwasaki M, Kanno A, Shimizu H, Yoshimoto T: "Neuromagnetic localization of spikes discharges correlates with postoperative seizure outcome"Jpn J Neurosurg (Tokyo) (Japanese). 9. 477-482 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] lshitobi M, Nakasato N, Munakata M, Inoue T, Takahashi S, Iinuma K: "Localization of normal and abnormal function in patients with band heterotopia. Katila T. et al. (ed.)"Proceedings of the 12th International Conference on Biomagnetism. 435-438 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanno A, Nakasato N, Nagamatsu K, Iwasaki M, Hatanaka K, Murayama N, Yoshimoto T: "Comparison of source localization for the P30m, P50m, and N100m peaks of the auditory evoked fields. Katila T. et al. (ed.)"Proceedings of the 12th International Conference on Biomagnetism. 25-28 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] wasaki M, Nakasato N, Shamoto H, Nagamatsu K, Kanno A, Hatanaka K, Yoshimoto T: "Interictal spike dipole estimation by MEG: Comparison with direct cortical recording by implanted grid electrodes. Katila T. et al. (ed.)"Proceedings of the 12th International Conference on Biomagnetism. 476-479 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hatanaka-K, Nakasato N, Nagamatsu K, Iwasaki M, Kanno A, Ikeda H, Yoshimoto T: "Modification of the pattern-evoked magnetic fields associated with the location of the lesion along the visual pathways. Katila T. et al. (ed.)"oProceedings of the 12th International Conference on Biomagnetism. 145-149 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaki Iwasaki: "Somatosensory evoked fields in comatose survivors after severe traumatic brain injury"Clinical Neurophysiology. 112. 205-211 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中里信和: "特集・てんかん研究-20世紀から21世紀へ-MEGとfMRIによるてんかん脳の機能検査"Brain Medical. 12(4). 39-46 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 社本 博: "脳神経外科で治療するてんかん"Brain Nursing. 17(7). 45 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kyoko Suzuki: "Judging semantic and episodic incongruity : a magnetoencephalographic study"Neuroreport. 12(2). 195-199 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 佐藤清貴: "術中脳表脳波を必要とするてんかん手術の麻酔管理"臨床麻酔. 25(2). 189-192 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中里信和: "特集臨床ナースのための 症状から見た緊急検査値の意味全身の症状 痙饗"臨床看護. 27(6). 736-739 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岩崎真樹: "MEGにて特異的に検出されたてんかん棘波"第16回日本生体磁気学会大会論文集. 14(1). 160-161 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 永松謙一: "口唇部電気刺激に対する脳表誘発電位と誘発磁界の比較"第16回日本生体磁気学会大会論文集. 14(1). 162-163 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 菅野彰剛: "交通外傷後遷延性意識障害患者における脳磁図発作間欠時異常波のMCE法による解析"第16回日本生体磁気学会大会論文集. 14(1). 164-165 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 畑中啓作: "MCE法によるパターンリバーサル刺激視覚誘発磁界の解析"第16回日本生体磁気学会大会論文集14(1) : 178-179, 2001. 14(1). 178-179 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 清水宏明: "特集functional MRIによる脳機能評価-基礎から臨床ヘ-functional MRIによる術前脳機能評価"脳の科学. 23. 775-782 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中里信和: "側頭葉てんかん外科治療における脳磁図診断の意義"臨床脳波. 43(9). 571-576 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中里信和: "ちよこっと教えて最先端医療診断脳磁図"Brain Nursing. 17(11). 67-71 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Sato: "Effect of Nitrous Oxide on Spike Activity During Epilepsy Surgery"Acta Neurochirurgica (Wien). 143. 1213-1216 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toshiki Endo: "Effect of sevoflurane on electrocorticography in patients with intractable temporal lobe epilepsy"J Neurosurgical Anesthesiology. 14(1). 59-62 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kiyotaka Sato: "Effect of sevoflurane on electrocorticogram in normal brain"J Neurosurgical Anesthesiology. 14(1). 63-65 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 社本 博: "脳磁図と術中脳波の併用が有効であった難治性前頭葉てんかん症例(印刷中)"脳神経外科. 30(4). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中里信和: "てんかん棘波の脳磁図解析と術後の発作予後"脳神経外科ジャーナル. 9. 477-482 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mamiko Ishitobi: "Remote discharges in the posterior language area during basa temporal stuimlation"Neuro Report. 11. 2997-3000 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中里信和: "てんかんの機能画像診断"画像診断. 21. 182-190 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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