• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular targets for signal transduction involved in the invasion and metastasis of malignant bone and soft tissue tumors.

Research Project

Project/Area Number 12557125
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

IWAMOTO Yukihide  Kyushu University, Graduate School of Medical Sciences, Prof., 大学院・医学研究院, 教授 (00213322)

Co-Investigator(Kenkyū-buntansha) TANAKA Kazuhiro  Kyushu University Hospital, Ass. Prof, 医学部附属病院, 助手 (10274458)
ODA Yoshinao  Kyushu University, Graduate School of Medical Sciences, Ass. Prof., 大学院・医学研究院, 講師 (70291515)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥7,400,000 (Direct Cost: ¥7,400,000)
KeywordsBone and soft tissue tumor / Metastasis / Invasion / Cytoskeleton / Signal transduction / Bone destruction / VEGF / 骨肉腫
Research Abstract

Distant metastasis is the most important factor to determine the prognosis of patients with malignant bone and soft tissue tumors. During the metastasis, tumor cells need to penetrate basement membrane twice; first intravasation at primary tumor, then extravasation at distant organs. Invasion of the basement membrane includes three steps, i.e., attachment to the membrane, destruction by catalytic enzymes, and movement of the cells into matrix of target organ. We have developed in vitro invasion assay and analyzed the molecular mechanisms of the tumor cell invasion and metastasis. We have reported that genes involved in the attachment, enzymatic degradation and motility are regulated simultaneously, and that the signaling pathway controlling the expression of these genes might be a good target for molecular based therapy of metastasis of malignant tumors. In the present study, our aim is to analyze the precise mechanisms of signal transduction pathway involved in the invasion and metast … More asis of tumor cells, and to develop the method for suppression of the invasive phenotypes of the tumor.
Previously, we have found that reagents which elevate intraceflular cAMP concentration inhibited invasion and experimental metastasis of HT1080 human fibrosarcoma cells. We further analyzed this phenomenon and found that cAMP analogues could suppress the activation Rho, a small GTP-binding protein, via protein kinase A, and inhibit actin stress fiber formation leading to reduction of phosphorylation of the focal adhesion kinase (FAK). Among three steps of the tumor cell invasion, phosphorylated FAK plays important roles in the cell motility, however, FAK might not affect the attachment and enzymatic degradation of the basement membrane. We confirmed the significance of the FAK phosphorylation in clinical samples of malignant fibrous histiocytoma (MFH), the most common malignant soft tissue tumor. In the specimen of MFH, the levels of FAK phosphorylation were elevated in recurrent samples than in the primary samples, suggesting the association of phosphorylated FAK and tumor cell invasion and recurrence. We further investigated the VEGF signals in bone destruction and found that VEGF-Flt1- FAK pathway might play important roles in the bone destruction and metastasis of malignant tumor. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (99 results)

All Other

All Publications (99 results)

  • [Publications] Saito T, et al.: "Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characters in synovial sarcoma"Histopathology. 40. 279-285 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "APC mutations in synovial sarcoma"J.Pathol.. 196. 445-449 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "Possible association between higher β -catenin mRNA expression and mutated β-catenin in sporadic desmoid tumors : Real-time semiquantitative assay by TaqMan PCR"Laboratory Invest.. 82. 97-103 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "Calponin and h-caldesmon expression in atypical fibroxanthoma and superficial leiomyosarcoma"Virchows.Arch.. 440. 404-409 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shiratsuchi H, et al.: "Mutation analysis of human cytokeratin 8 (KRT 8) in malignant rhabdoid tumor : A possible contibution to intracytoplasmic inclusion body formation"Mod.Pathol.. 15. 146-153 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itokawa T, et al.: "Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling"Molecular Cancer Therapeutics. 1. 295-302 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "Solitary lymphangioma of the femur. A case report"J.Orthop.Sci.. 7. 504-504 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyajima K, et al.: "Clinicopathologic prognostic factors in soft tissue lelomyosarcoma. A multivariate analysis"Histopathology. 40. 353-359 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishio J, et al.: "Establishment of a new human synovial sarcoma cell line, FU-SY-1, that express c-MET receptor and its ligand hepatocyte growth factor"Int.J.Oncol.. 21. 17-23 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oda Y, et al.: "Molecular genetic abnormalities and their usefulness for diagnosis and prediction of prognosis in soft-tissue sarcomas"Recent Res.Devel.Cancer. 4. 305-315 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "Low-grade fibrosarcoma of the proximal humerus. A case report with a review of literatures"Pathol.Int.. 53. 49-54 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oda Y, et al.: "Letter to the Editor ; Leiomyosarcoma versus myofibrosarcoma. Author's reply"Am.J.Surg.Pathol.. 26. 394-396 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto Y, et al.: "Possible involvenemt of the vascular endothelial growth factor-Flt-1-Focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints"J.Immunology. 168. 5824-5831 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "Vascular compression caused by solitary osteochondroma : useful diagnostic methods of magnetic resonance angiography and Doppler ultrasonography"J.Orthop.Sci.. 7. 439-443 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka K, et al.: "High-dose chemotherapy and autologous peripheral blood stem cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumors"J.Orthop.Sci.. 7. 477-482 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "β-catenin accumulation and gene mutation in Exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma"Arch Pathol.Lab.Med.. 126. 1071-1078 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawaguchi K, et al.: "Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40years"Mod.Pathol.. 15. 878-888 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oda Y, et al.: "Reassessment and clinicopathological progonostic factors of malignant fibrous histiocytoma of soft parts"Pathol.Int.. 52. 595-606 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T.et al.: "Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characters in synovial sarcoma."Histopathology. 40. 279-285 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "APC mutations in synovial sarcoma."J. Pathol.. 196. 445-449 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "Possible association between higher β-catenin mRNA expression and mutated β-catenin in sporadic desmoid tumors: Real-time semiquantitative assay by TaqMan Polymerase Chain Reaction"Laboratory Invest.. 82. 97-103 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "Calponin and h-caldesmon expression in atypical fibroxanthoma and superficial leiomyosarcoma."Virchows. Arch.. 440. 404-409 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shiratsuchi H, et al.: "Mutation analysis of human cytokeratin 8 (KRT 8) in malignant rhabdoid tumor: A possible contibution to intracytoplasmic inclusion body formation."Mod. Pathol.. 15. 146-153 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itokawa T, et al.: "Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling."Molecular Cancer Therapeutics. 1. 295-302 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto Y, et al.: "Possible involvenemt of the vascular endothelial growth factor-Flt-1-Focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints."J. Immunology. 168. 5824-5831 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "Vascular compression caused by solitary osteochondroma: useful diagnostic methods of magnetic resonance angiography and Doppler ultrasonography."J. Orthop. Sci.. 7. 439-443 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka K, et al.: "High-dose chemotherapy and autologous peripheral blood stem cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumors."J. Orthop. Sci.. 7. 477-482 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A, et al.: "β-catenin accumulation and gene mutation in Exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma."Arch Pathoi. Lab. Med.. 126. 1071-1078 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawaguchi K, et al.: "Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years."Mod. Pathol.. 15. 878-888 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oda Y, et al.: "Reassessment and clinicopathological progonostic factors of malignant fibrous histiocytoma of soft parts."Pathol. Int.. 52. 595-606 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto A. et al.: "Solitary lymphangioma of the femur. A case report."J. Orthop. Sci.. 7. 504-504 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyajima K, et al.: "Clinicopathologic prognostic factors in soft tissue leiomyosarcoma. A multivariate analysis."Histopathology. 40. 353-359 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishio J, et al.: "Establishment of a new human synovial sarcoma cell line, FU-SY-1, that express c-MET receptor and its ligand hepatocyte growth factor."Int. J. Oncol.. 21. 17-23 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oda Y, et al.: "Molecular genetic abnormalities and their usefulness for diagnosis andprediction of prognosis in soft-tissue sarcomas"Recent Res. Devel. Cancer. 4. 305-315 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "Low-grade fibrosarcorna of the proximal humerus. A case report with a review of literatures."Pathol. Int.. 53. 49-54 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oda Y, et al.: "Letter to the Editor; Leiomyosarcoma versus myofibrosarcoma. Author's reply."Am. J. Surg. Pathol.. 26. 394-396 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T, et al.: "Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characters in synovial sarcoma"Histopathology. 40. 279-285 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saito T, et al.: "APC mutations in synovial sarcoma"J. Pathol.. 196. 445-449 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saito T, et al.: "Possible association between higher β-catenin mRNA expression and mutated β-catenin in sporadic desmoid tumors : Real-time semiquantitative assay by TaqMan PCR"Laboratory Invest. 82. 97-103 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakamoto A, et al.: "Calponin and h-caldesmon expression in atypical fibroxanthoma and superficial leiomyosarcoma"Virchows. Arch.. 440. 404-409 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shiratsuchi H, et al.: "Mutation analysis of human cytokeratin 8 (KRT 8) in malignant rhabdoid tumor : A possible contibution to intracytoplasmic inclusion body formation"Mod. Pathol.. 15. 146-153 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Itokawa T, et al.: "Antiangiogenic effect by SU5416 is party attributable to inhibition of Flt-1 receptor signaling"Molecular Cancer Therapeutics. 1. 295-302 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto Y, et al.: "Possible involvenemt of the vascular endothelial growth factor-Flt-1-Focal adhesion kinase pathway in chemotaxis and the cell proliferation of orthoclase precursor cells in arthritic joints"J. Immunology. 168. 5824-5831 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakamoto A, et al.: "Vascular compression caused by solitary osteochondroma : useful diagnostic methods of magnetic resonance angiography and Doppler ultrasonography"J. Orthop. Sci.. 7. 439-443 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka K, et al.: "high-dose chemotherapy and autologous peripheral blood stem cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumors"J. Orthop. Sci.. 7. 477-482 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakamoto A, et al.: "β-catenin accumulation and gene mutation in Exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma"Arch Pathol. Lab. Med.. 126. 1071-1078 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawaguchi K, et al.: "Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years"Mod. Pathol.. 15. 878-888 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oda Y, et al.: "Reassessment and clinicopathological progonostic factors of malignant fibrous histiocytoma of soft parts"Pathol. Int.. 52. 595-606 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakamoto A, et al.: "Solitary lymphangioma of the femur. A case report"J. Orthop. Sci.. 7. 504-504 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyajima K, et al.: "Clinicopathologic prognostic factors in soft tissue leiomyosarcoma. A multivariate analysis"Histopathology. 40. 353-359 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishio J, et al.: "Establishment of a new human synovial sarcoma cell line, FU-SY-1, that express c-MET receptor and its ligand hepatocyte growth factor"Int. J. Oncol.. 21. 17-23 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oda Y, et al.: "Molecular genetic abnormalities and their usefulness for diagnosis and prediction of prognosis in soft-tissue sarcomas"Recent Res. Devel. Cancer. 4. 305-315 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saito T, et al.: "Low-grade fibrosarcoma of the proximal humerus. A case report with a review of literatures"Pathol. Int.. 53. 49-54 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oda Y, et al.: "Letter to the Editor ; Leiomyosarcoma versus myofibrosarcoma. Author's reply"Am. J. Surg. Pathol.. 26. 394-396 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 播广谷 勝三, 岩本 幸英(分担執筆): "今日の処方 第3版"南江堂. 935 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松田 秀一, 岩本 幸英(分担執筆): "新OS NOW 新世代の整形外科手術、No.13"Medical View社. 192 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 岩本 幸英(分担執筆): "別冊 NHK きょうの健康"日本放送出版協会. 255 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto Y, et al.: "Small GTP-binding Protein, Rho, Both Increased and Decreased Cellular Motility, Activation of Matrix Metalloproteinase 2 and Invasion of Human Osteosarcoma Cells"Jpn. J. Cancer Res.. 92. 429-438 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsumoto Y, et al.: "Downregtlation ant forcec expression of EWS-Fli I fusion gene re stits in changes in the expression of C(1) regulatory genes"Brit. J. Cancer. 84. 768-775 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saito T, et al.: "Expression of intercellular adhesion molecules in epith elioid sarcoma and malignant rhabdoid tumor"Pathol. Int.. 51. 532-542 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Oda Y, et al.: "Pleomorphic Leiomyosarcoma-Clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibros histiocytoma"Am. J. Surg. Pathol. 25. 1030-1038 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saito T, et al.: "β-catcin nuclear expression corrclatcs with cyclin DI overexpression in sporadic desmoid tumors"J. Pathol.. 195. 222-228 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Naka T, et al.: "Immunohistochemical analysis of E-cadherin, alpha-, beta-, gamma-cetenins, and neural cell adhesion moleculc(NCAM) in chordoma"J. Clin. Pathol.. 54. 945-950 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakamoto A, et al.: "H-ras oncogene mutation in dedifferentiated liposarcoma : Polymerize chain reaction-restriction fragment length polymorphism analysis"Am. J. Clin. Pathol.. 115. 235-242 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saito T, et al.: "E-Cadherin Gene Mutations Frequently Occur in Synovial Sarcoma as a Determinant of Histologica Features"Am. J. Pathol.. 159. 2117-2124 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakamoto A, et al.: "Immunoexpression of Neurofibromin, S-100 Protein and Leu-7, and Mutation Analysis of the NF1 Gene at Codon 1423 in Osteofibros Dysplasia"Hum. Pathol.. 32. 1245-1251 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakamoto A, et al.: "H-, K-and N-ras Gene Mutation in Atypical Fibroxanthoma and Malignant fibrous Histiocytoma"Hum. Pathol.. 32. 1225-1231 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakamoto A, et al.: "Immunoexpression of ultraviolet photoproducts and p53 mutation analysis in atypical fibroxanthoma and superficial malignant fibrous histiocytoma"Mod. Pathol.. 14. 581-588 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakamoto A, et al.: "H-ras oncogene mutation in dedifferentiated chondrosarcoma : Polymerase chain reaction-restriction fragment lengt polymorphism analysis of paraffin-embedded tissues"Mod. Pathol.. 14. 343-349 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Oda Y, et al.: "Secondary malignant giant-cell tumor of bone. Molecular abnormalitiesof p53 and H-ras gene correlated with malignant transformation"Histopathology. 39. 629-637 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kinoshita Y, et al.: "Mutation of the p53 gene mutations in malignant rhabdoidtumors of soft part and kidney : Immunohistochemical and DNA direct sequence analysis"J. Cancer Res. Clin. Oncol.. 127. 351-358 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shiratsuhi H, et al.: "Cytokeratin sibunits of inclusion bodies in rhabdoid cells : Immunohistochemidal and clinicopathological study of malignant rhabdoid tumor and epithelioid sarcoma"Int. J. Surg. Pathol.. 9. 37-48 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Miyajima K, et al.: "Relative quantitation of p53 and MDM2 gene expression in leiomyo sarcoma ; rear-time semi-quantitative reverse transcription-polymerase chain reaction"Cancer Letters. 164. 177-188 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Watanabe T, et al.: "Malignantperipheraln ervesheathtumorarising within neuro fibromaAn immuno histochemical analysis in the comparison between benign and malignant components"J. Clin. Pathol.. 54. 631-636 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Adachi T, et al.: "Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Masuda K, Tsuneyoshi Mlmmunoreactivily of p53. mdrn2 and p21/WAF1 in dedifferentiated liposarcoma : special emphasis on the distinet immunophenotype of the Well-differentiated component"Int. J. Surg. Pathol.. 9. 99-109 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岩本幸英(分担執筆): "今日の治療指針2001年度版-私はこう治療している-"医学書院. 1566 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 播广谷勝三, 岩本幸英(分担執筆): "今日の処方,第3版"南江堂. 935 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松田秀一, 岩本幸英(分担執筆): "新OS NOW 新世代の整形外科手術,No.13高齢者に対する整形外科手術-より高い機能を求めて"Medical View社. 192 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Oda Y: "Expression of hepatocyte growth factor (HGF)/Scatter factor and its receptor c-MET correlates with poor prognosis in synovial sarcoma."Hum.Pathol. 31(2). 185-192 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Oda Y: "Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma ; A clinicopathologic and immunohistochemical study."Hum.Pathol. 31(6). 709-716 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakamoto A: "A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gs α mutation at Arg^(201) codon : Polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues."J.Molecular Diagnostics. 2(2). 67-72 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Oda Y: "Establishment of new multidrug-resistant human osteosarcoma cell lines."Oncology Reports. 7. 859-866 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsuda S: "Treatment of myxoid liposarcoma in pregnancy."Clin.Orthop.Related Res. 376(7). 195-199 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukushi J: "The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13"J.Immunol.. 165;. 2818-2823 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Oda Y: "Molecular abnormalities of p53, MDM2, and H-ras in synovial sarsoma"Mod.Pathol,. 13(9). 994-1004 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito T: "Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of β-catenin mutations in synovial sarcoma"J.Pathol.. 192. 342-350 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Harimaya K: "Antioxidants inhibit TNF α-induced motility and invasion of human osteosarcoma cell : possible involvement of NFkB activation"Clin Exp.Metastasis. 18. 121-129 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawaushi S: "Prognostic significance of apostosis in synovial sarcoma : Correlation with clinicopathologic parameters, cell proliferative activity and expression of apoptosis-related proteins."Mod.Pathol. 13. 755-765 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakamoto A: "H-ras oncogene mutation in dedifferentiated liposarcoma : Polymerase chain reaction-restriction fragment length polymorphism analysis."Am.J.Clin.Pathol. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakamoto A: "H-ras oncogene mutation in dedifferentiated chondrosarcoma : Polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues"Mod.Pathol. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 宮城知之: "Ewing肉腫患者における末梢血幹細胞採取レジメンの検討"整形外科と災害外科. 49(1). 278-282 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 増田義武: "胸椎に発生した巨大な軟骨肉腫の2例"整形外科と災害外科. 49(4). 1097-1103 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松田秀一: "骨肉腫切除後の再建法-人工関節を用いた再建-"整形外科と災害外科. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 岩本幸英(分担執筆): "新OS NOW新世代の整形外科手術、No.5 「広範骨欠損の再建手術」"Medical View社. 204 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岩本幸英(分担執筆): "整形外科・病理 悪性骨腫瘍取扱い規約"金原出版. 180 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岩本幸英(分担執筆): "整形外科専門医をめざすための経験すべき外傷・疾患88"Medical View社. 374 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 田仲和宏(分担執筆): "先端医療シリーズ8整形外科 整形外科〜診断と治療の最先端〜"先端医療技術研究所. 543 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岩本幸英(分担執筆): "今日の治療指針2001年度版-私はこう治療している-"医学書院. 1566 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 播广谷勝三(分担執筆): "今日の処方 第3版"南江堂(印刷中). (2001)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi