| Project/Area Number |
12557129
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gifu University |
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Principal Investigator |
DOHI Shuji School of Medicine Professor, 医学部, 教授 (40155627)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Hiroshi Daiichi Seiyaku chief researcher, 主任研究員
YANAGIDATE Fumi University Hospital assistant, 医学部附属病院, 助手 (60313889)
MICHINO Tomohiro University Hospital assistant, 医学部附属病院, 助手 (80283315)
菊地 寛 第一製薬, 創剤研究所, 主任研究員
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2002: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2000: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | opioids / oxycodone / MAPK / morphine / epidural / pontine reticular formation / side effects / オキソコドン / microsphera / カルバコール / ムスカリン受容体 / 硬膜外鎮痛 / ポリマー化 / ACh受容体 / 術後痛 / 硬膜外オピオイド |
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| Research Abstract |
It would be very convenient and practical that a slow release of opioid injected into the epidural space is able to be effective for 3〜4 days in postoperative patients. A copolymer paste containing opioid is such one possibility to provide more effective and convenient mean for postoperative analgesia.
To examine such possibility as well as safety of epidural administration of an old opioid, oxycodone which, with oral slow releasing tablet, has recently been used in the US, we have done rats' experiments and found that oxycodone administered into the pontine reticular formation did not cause any sedative and analgesic effect, but its spinal administration caused a potent analgesia. Charbacol, a muscarinic agonist, produced analgesic action when administered both into the pontine and into the spinal subarachnoid space. Since morphine affects phosphorylation of MAPK kinase, we examined such effects of oxycodone using PC12 cell line and found that oxycodone did not affect activation of MAPK kinase. Then we have done clinical studies to examine effect of epidural oxycodone in 60 postoperative patients after approving with the human investigation committee. We found that epidural oxycodone is similarly effective for postoperative pain with less side effects such as nausea and vomiting.
Although we could not be able to make a slow releasing solution of opioid which is available for epidural administration, it would provide a prolong analgesia for 3-4 days even with a single injection of such slow release of opioid into the epidural space. Since a drug company has recently started to make such injectable opioid with slow releasing property, research for a new drug-delivery system for injectable opioid would be promising.
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