| Project/Area Number |
12557147
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
TANO Yasuo Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (80093433)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKA Shunji Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (60260387)
OHJI Masato Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (90252650)
FUJIKADO Takashi Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (50243233)
笠松 充男 (株)ニデック, 技術部・レーザー研究室, 室長
KASAMATSU Mitsuo Nidek Inc., Research Director
林 篤志 大阪大学, 医学系研究科, 助手 (20283773)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2001: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2000: ¥9,200,000 (Direct Cost: ¥9,200,000)
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| Keywords | Choroidal neovascularization / Foveal Translocation Surgery / Retinal Detachment / Astigmatism / TdT-dNTP terminal nick end labeling(TUNEL) |
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| Research Abstract |
Despite of the increased number of the patients with choroidal neovascularization, there is no effective treatment for the present. Conventional treatments includes laser treatment or removal of the neovascular membrane. However, these treatment is not satisfactory yet. Transfoveal surgery is thought to be an only treatment that will rescue those patients with choroidal neovascularization. Since intraoperative surgical techniques or procedures are not well established yet, we tried to optimize the surgeries on the animal experiment basis.
First, we found that retinal folds in translocation surgery showed extensive apoptosis of photoreceptor cells in dog eyes, indicating that the foveal translocation surgery needs to be planned to avoid involving the fovea in the retinal folds. The second finding was that intravitreal irrigation with Ca(2+)-free and Mg(2+)-free balanced salt solution decreased the adhesion between the retinal pigment epithelial cells and retinal outer segments of the photoreceptor cells and made the creation of retinal detachment less traumatic. And the third finding was that an excessive scleral resection in the radial direction can cause clinically intolerable regular and irregular astigmatism in foveal translocation surgery with scleral shortening, suggesting that minimal scleral shortening was recommended to reduce the risk and /or benefit of the patients.
Although the techniques for transfoveal surgery are not perfect yet, we expect a better visual outcome of the patients with chroidal neovascularization using the surgical modification stated above.
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