| Project/Area Number |
12557162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
補綴理工系歯学
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
YOKOYAMA Atsuro Hokkaido Univ., Dental Hospital, Assi.Prof., 歯学部附属病院, 講師 (20210627)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHINO Humihiro Hokkaido Univ., Grad.School of Dental Medicine, Instructor, 大学院・歯学研究科, 助手 (50301891)
YASUDA Motoaki Hokkaido Univ., Grad.School of Dental Medicine, Asso.Prof., 大学院・歯学研究科, 助教授 (90239765)
SHINDOH Masanobu Hokkaido Univ., Grad.School of Dental Medicine, Asso.Prof., 大学院・歯学研究科, 助教授 (20162802)
NAKASU Masanori Pentax.Co.Ltd., R&D Devision, Researcher, 開発部, 研究員
KAWASAKI Takao Hokkaido Univ., Grad.School of Dental Medicine, Prof., 大学院・歯学研究科, 教授 (90002229)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | calcium phosphate cement / β-TCP / CM-chitin / BMP / cancellous bone / immediate implant / 骨補填材 / オステオカルシン / ポリ乳酸 / 多孔質 / 遺伝子導入 |
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| Research Abstract |
The purpose of this study was to densify the sparse cancellous bone to achieve the early convalescence of the occlusal function in the immediate implant after tooth extraction. Firstly, we developed the calcium phosphate cement with the sufficient plasticity for easy molding into the desired shape. This cement had the good handling property and biocompatibility. Furthermore, we developed the sandwich technique and suggested that it was effective for the jaw bone augmentation. Although it was possible to make the calcium phosphate cement with porous structure, it was impossible to develop the calcium phosphate cement with bio-absorbability. It is necessary to make the cement with bio-absorbability for densification the cancellous bone. Therefore, we developed β-TCP-CM-chitin composite material that was injectable from the # 14 needle. No inflammatory response was observed when this composite was implanted in soft tissue and bone tissue. It showed this material had good biocompatibility. Active bone formation was observed in subcutaneous tissue when it was implanted with BMP. The problems such as BSE on the collagen are reported, while collagen was used for the carrier for BMP usual. It was suggested that this composite material was suitable for the carrier for BMP. Histological investigation was carried out to evaluate the effectiveness of this composite material as a bone substitute. At I week after implant, active bone formation was observed on the surface of the material. Absorption of the material and replacement to the bone was seen with time. It was showed that the cancellous bone was densified. These results suggested that the possibility of the early convalescence of the occlusal function in the immediate implant after tooth extraction.
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