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With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :

Research Project

Project/Area Number 12557162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 補綴理工系歯学
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

YOKOYAMA Atsuro  Hokkaido Univ., Dental Hospital, Assi.Prof., 歯学部附属病院, 講師 (20210627)

Co-Investigator(Kenkyū-buntansha) HIGASHINO Humihiro  Hokkaido Univ., Grad.School of Dental Medicine, Instructor, 大学院・歯学研究科, 助手 (50301891)
YASUDA Motoaki  Hokkaido Univ., Grad.School of Dental Medicine, Asso.Prof., 大学院・歯学研究科, 助教授 (90239765)
SHINDOH Masanobu  Hokkaido Univ., Grad.School of Dental Medicine, Asso.Prof., 大学院・歯学研究科, 助教授 (20162802)
NAKASU Masanori  Pentax.Co.Ltd., R&D Devision, Researcher, 開発部, 研究員
KAWASAKI Takao  Hokkaido Univ., Grad.School of Dental Medicine, Prof., 大学院・歯学研究科, 教授 (90002229)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥4,100,000 (Direct Cost: ¥4,100,000)
Keywordscalcium phosphate cement / β-TCP / CM-chitin / BMP / cancellous bone / immediate implant / 骨補填材 / オステオカルシン / ポリ乳酸 / 多孔質 / 遺伝子導入
Research Abstract

The purpose of this study was to densify the sparse cancellous bone to achieve the early convalescence of the occlusal function in the immediate implant after tooth extraction. Firstly, we developed the calcium phosphate cement with the sufficient plasticity for easy molding into the desired shape. This cement had the good handling property and biocompatibility. Furthermore, we developed the sandwich technique and suggested that it was effective for the jaw bone augmentation. Although it was possible to make the calcium phosphate cement with porous structure, it was impossible to develop the calcium phosphate cement with bio-absorbability. It is necessary to make the cement with bio-absorbability for densification the cancellous bone. Therefore, we developed β-TCP-CM-chitin composite material that was injectable from the # 14 needle. No inflammatory response was observed when this composite was implanted in soft tissue and bone tissue. It showed this material had good biocompatibility. Active bone formation was observed in subcutaneous tissue when it was implanted with BMP. The problems such as BSE on the collagen are reported, while collagen was used for the carrier for BMP usual. It was suggested that this composite material was suitable for the carrier for BMP. Histological investigation was carried out to evaluate the effectiveness of this composite material as a bone substitute. At I week after implant, active bone formation was observed on the surface of the material. Absorption of the material and replacement to the bone was seen with time. It was showed that the cancellous bone was densified. These results suggested that the possibility of the early convalescence of the occlusal function in the immediate implant after tooth extraction.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report

Research Products

(14 results)

All Other

All Publications (14 results)

  • [Publications] 横山敦郎, 山本悟, 小松原浩実, 武石篤典, 川崎貴生, 向後隆男, 中須正議: "骨補填材を目的としたCM-キチン-コハク酸含有型リン酸カルシウムセメントの開発"補綴誌. 44. 9-18 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A.Yokoyama, S.Yamamoto, T.Kawasaki, T.Kohgo, M.Nakasu.: "Development of calcium phosphate cement using chitosan and citric acid for bone substitutes"Biomaterials. 23. 1091-1101 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大堀ことは, 横山敦郎, 川崎貴生, 飯塚正, 向後隆男: "非吸収性膜がアパタイトブロックの骨膜下埋入後の骨形成に及ぼす影響"補綴誌. 46. 712-721 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A.Yokoyama, H.Matsuno, S.Yamamoto, T.Kawasaki, T.Kohgo, M.Uo, F.Watari, M.Nakasu: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin"J Biomed Mater Res. 64A. 491-501 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] R.Fujita, A.Yokoyama, T.Kawasaki, T.Kohgo: "Bone augmentation osteogenesis using hydroxyapatite and β-tricalcium phosphate blocks"J Oral Maxillofac Surg. 61. 1045-1053 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] R.Fujita, A.Yokoyama, Y.Nodasaka, T.Kohgo, T.Kawasaki: "Ultrastructure of ceramic-bone interface using hydroxyapatite and β-tricalcium phosphate ceramics and replacement mechanism of β-tricalcium phosphate in bone"Tissue & Cell. 35. 427-440 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yokoyama A, Yamamoto S, Komatsubara H, Takeishi A, Kawasaki T, Kohgo T, Nakasu M.: "Development of calcium phosphate cement containing carboxymethyl-chitin and succinic acid for bone substitute"J Jpn Prosthodont Soc. 44. 9-18 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yokoyama A, Yamamoto S, Kawasaki T, Kohgo T, Nakasu M.: "Development of calcium phosphate cement using chitosan and citric acid for bone substitute materials"Biomaterials. 23. 1091-1101 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohori K, Yokoyama A, Kawasaki T, Iizuka T, Kohgo T.: "Effect of non-resorbable membrane on bone formation after implant of apatite blocks on bone."J Jpn Prosthodont Soc. 46. 712-721 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yokoyama A, Matsuno H, Yamamoto S, Kawasaki T, Kohgo T, Uo M, Watari F, Naksu M: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin."J Biomed Mater Res. 64A. 491-501 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita R, Yokoyama A, Kawasaki T, Kohgo T.: "Bone augmentation osteogenesis using hydroxy-apatite and β-tricalcium phosphate blocks."J Oral Maxillofac Surg. 61. 1045-1053 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita R, Yokoyama A, Nadasaka Y, Kohgo T., Kawasaki T: "Ultrastructure of ceramic-bone interface using hydroxyapatite and β-tricalcium phosphate ceramics and replacement mechanism of β-tricalcium phosphate in bone."Tissue & Cell. 35. 427-440 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Atsuro Yokoyama: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin"Journal of Biomedical Materials Research. vol.62,issue3. 491-501 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Atsuro Yokoyama: "Development of calcium phosphate cement using chitosan and citric acid for bone substitute materials"Biomaterials. 23・4. 1091-1101 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2000-03-31   Modified: 2016-04-21  

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