| Project/Area Number |
12558115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KAWASAKI MEDICAL SCHOOL |
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Principal Investigator |
NAKAMOTO Hiroshi Kawasaki Medical School,Medical Engineering,Research Associate, 医学部, 助手 (10299183)
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| Co-Investigator(Kenkyū-buntansha) |
YADA Toyotaka Kawasaki Medical School, Medical Engineering, Assistant Professor, 医学部, 講師 (00210279)
OGAWASARA Yasuo Kawasaki Medical School, Medical Engineering, Associate Professor, 医学部, 助教授 (10152365)
KAJIYA Fumihiko Okayama University, Graduate School of Medical and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (70029114)
YAMAMORI Shinji Nihon Kohden Co., R&D Center, Manager, R&Dセンター, 部長(研究職)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2001: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥8,700,000 (Direct Cost: ¥8,700,000)
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| Keywords | kidny glomerulus / capillaries / high speed CCD microscope / renal circulation / blood flow velocity |
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| Research Abstract |
Diameter of afferent arterioles of spontaneous hypertensive rats (SHR) was larger than that of normal control rats (WKY). Balnidipine, a calcium antagonist dilated both afferent and efferent arterioles contrary to the previous reports in a dose-dependent manner in any of those hypertensive, diabetic and normal rats. Erythrocyte velocity within i> glomerular capillaries of diabetic rats was faster than that of WKY rats for the first time. Angiotensin II, which elevates blood pressure increased average erythrocyte velocity within glomerular capillaries in a dose-dependent manner in normal control rats.
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