| Project/Area Number |
12575034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Mie University |
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Principal Investigator |
YAMAUCHI Toru Mie University, Faculty of Medicine, Professor, 医学部, 教授 (80045674)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Kazuo Mie University, Faculty of Medicine, Professor, 医学部, 教授 (20181828)
PIAO Fengyuan Mie University, Faculty of Medicine, Assist.Professor, 医学部, 講師 (50283528)
ISHIKAWA Hitoshi Mie University, Faculty of Medicine, Assoc.Professor, 医学部, 助教授 (50250915)
MATSUMOTO Yutaka Hokkaido Institute for Environmental Science Research, Chief Researcher, 主任研究員
TIAN Ying Mie University, Faculty of Medicine, Assist.ant, 医学部, 助手 (70335115)
塚田 進 三重県科学技術振興センター, 保険環境研究部, 主幹研究員
荒木 恵一 三重県科学技術振興センター, 保健環境研究所, 主幹研究員
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2002: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2001: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2000: ¥6,300,000 (Direct Cost: ¥6,300,000)
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| Keywords | Mutagenic activity / PAHs / Atmospheric air / respiratory complains / respiratory functions / micro nucleus / DNA polymorphism / genotosicity / carcinogenecity / cancer mortality / 環境保健疫学調査 / 中国瀋陽市工業地区 / 大気汚染 / 大気中変異原活性 / 変異原性物質 / 小核試験 / 薬物代謝酵素の遺伝子多型 / 肺癌死亡率 / 呼吸器検査所見 / 肺癌家族歴 / 異常妊娠既往歴 |
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| Research Abstract |
We investigated the effect of mutagenic activity in atmospheric air on residential health in a polluted area of Shenyang City, China, from 2000 to 2002. 1. The concentration of 9 polycyclic aromatic hydrocarbons (PAHs) in air ranged from 10 to 906ng/m^3 and showed the highest levels in the industrial area and the near trunk road junction in winter. The annual average of mutagenic activity was high for TA100(+S9) and low for TA98(-S9). 2 The concentration of 13 heavy metals in suspended particles showed the highest levels in the industrial area followed by the near trunk road junction. The level of As, Cr and Ni as carcinogenic metals were 57.4, 206.0 and 69.5ng/m^3, respectively, and were about 40, 30 and 10 times as much as those in Mie prefecture, Japan. 3. The prevalence rates of respiratory complains were significantly higher in the polluted area than in control area for not only subject themselves but their parents. Moreover, the prevalence rate of lung cancer in parents was also
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significantly higher in the polluted area than in control area. The rate of the history of abortion and/or still birth in the married female subjects was significantly higher in the polluted area than in control area. The respiratory functions of the non-smoke female subjects indicating the disturbance of the peripheral air way such as FEV1.0%, V25 and V25/Ht were significantly lower averages in the pollutes area than in control area. 4. To evaluate the genotoxic effects of atmospheric air pollution in vivo and in vitro, we aimed to assess prospectively the association between air pollution level and genetic damage in vivo and in vitro in industrial and rural areas in Shenyang. After adjustment for potential confounders, individuals who live in industrial area had received greater genotoxicities and air samples from industrial area indicated that higher mutagenecities in bacterial assay (Ames test). 5. The age adjusted mortality (AAM) of whole cancers and lung cancer for 1996-2000 were compared between Shenyang City and Japan, and the air polluted and control areas. The AAM of whole cancers ranged 260-275 in male and 134-177 per 10^5 population in female in Shenyang City, and were about 1.2 in male and 1.5 times in female as much as in Japan. The AAM of whole cancers was higher in the pollute area than in control area. The AAM of lung cancer was higher in the polluted area than in control area in 1996, but the difference of both rates was decreased year by year and none was found in 2000. Less
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