| Project/Area Number |
12576001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | SHINSHU UNIVERSITY |
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Principal Investigator |
SAKAI Akio SHINSHU UNIVERSITY, ASSOCIATE PROFESSOR, 医学部, 助教授 (70020758)
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| Co-Investigator(Kenkyū-buntansha) |
SAITHOU Muneo CENTER INSTITUTE FOR EXPERIMENTAL ANIMALS, CHIEF, 室長 (50167417)
MATSUZAKI Tetsuya CENTER INSTITUTE FOR EXPERIMENTAL ANIMALS, CHIEF, 室長 (30167647)
MATSUMOTO Takaaki AICHI MEDICAL UNIVERSITY, ASSOCIATE PROFESSOR, 助教授 (60199875)
ISHIZAKI Takeshi FUKUI MEDICAL UNIVERSITY, PROFESSOR, 教授 (80151364)
KOIZUMI Tomonobu SHINSHU UNIVERSITY, ASSISTANT PROFESSOR, 医学部, 講師 (20273097)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2002: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2001: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2000: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | high altitude / pulmonary hypertension / right ventricular hypertrophy / Adaptation / Pika / blue sheep / Yak / 肺高血圧 |
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| Research Abstract |
The blue sheep as well as pika, and yak live in the Tibetan highlands to an altitude of 6,100 m and are typical animals adapted to high altitude among mammals of the world. These animals have a long history of habitation at high altitude and are considered to be "animals completely adapted to high altitude" because of their physiologic and morphological traits well-adapted to high-altitude environments. To evaluate physiologic characteristics of high-altitude adaptation of the blue sheep, changes in the pulmonary hemodynamics were examined in Qinghai Province, China (altitude 3,750 m). Primary items of measurement were the body weight (BW), systemic arterial pressure (Psa), pulmonary artery pressure (Ppa), hematocrit (Ht), left ventricular weight (LVW), right ventricular weight (RVW), and the blood gas profile. The principal finding of this study are: 1) Ht, at index of right ventricular hypertrophy (RVW/LVW), and oxygen consumption (VO2) were significantly smaller in the blue sheep compared with the pigs; 2) Ppa/Psa, an index of the right ventricular load, increased with the altitude in both species, but the increases were smaller in the blue sheep. From these observations, small Ht and RVW/LVW are considered to be characteristics of animals completely adapted to high altitude such as the pika.
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