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Gene analysis familially condensed juvenile diabetics developed sporadically in Indonesia

Research Project

Project/Area Number 12576021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Metabolomics
Research InstitutionKobe University

Principal Investigator

TANIGUCHI Hiroshi  Kobe University, School of Medicine, Professor, 医学部, 教授 (70030989)

Co-Investigator(Kenkyū-buntansha) KATAOKA Nobumasa  Kobe University, School of Medicine, Associate Professor, 医学部, 助教授 (80071398)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2000: ¥4,400,000 (Direct Cost: ¥4,400,000)
KeywordsDiabetes Mellitus / Obesity / Susceptible genes / Indonesia / Papua New Guinea / Gene polymorphism / PPARγ2遺伝子 / UCP-1遺伝子 / 遺伝子
Research Abstract

Polymorphisms of diabetos-and obosity-susceptible genes were analysed using PCR-PFLP method in inhabitants of Indonesia and its vecinal Papua New Guinea.
The results were as follows :
(1) In Indonesia
(1)-112A→C polymorphism of UCP-1 gene was not associated with obesity, but its C-allele frequency of Java islanders was higher than that of native inhabitants of Bali, and comparable to that of Japanese.
(2)Frequency of Pro12Ala polymorphism of PPARγ2 gene was lower than one half of that of Caucasians, and that of native inhabitants of Bali was null.
(3)3243A→G mutation of mitochondrial DNA was not found.
(4)SNP45T→G polymorphism of adiponectin gene was associated with obesity in native people of Bali, and also with glucose tolerance. However, SNP276 polymorphism did not reveal such association.
(5)-55C→T polymorphism of UCP-3 gene was related to obesity in native people of Bali and Irian Jaya, and also with glucose tolerance.
(2) In Papua New Guinea
(1)MetA16Val polymorphism of axon 1O of glycogen synthase had no association with obesity but its frequency was higher than that of Japanese.
(2)Pro12Ala polymorphism of PPARγ2 gene was not detected.
(3)Frequency of Trp64Arg polymorphism of β2 adrenergic receptor gene was higher in obese subjects.
(4)-112A→C mutation of UCP-1 gene was detected rarely, while Met229Leu polymorphism was not.
(5)-55C→T polymorphism of UCP-3 gene was not associated with obesity.
(6)-308G→A and -238G→Amutation of TNFα gene was not observed.
(7)Frequency of SNP276T→G mutation and G-allele of adiponectin gene was not related to obesity but was higher than that of Japanese.
These results indicate that frequency of diabetes-and obesity-susceptible gene polymorphisms varies among ethnic groups and people inhabiting in different regions in Indonesia and Papua New Guinea. Besides, the recently increasing incidence of diabetes in these countries appears to be due to not only the change of life-style through rapid Westernization but possession of the susceptible genes.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] 坂上元祥: "Papua New Guinea肥満者におけるperoxisome proliferator-activated receptor γ2Pro12Ala(PPARγ2P12A)多型性の解析"糖尿病. 44. S89 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] W.Danawati: "Low prevalence of the substitution of adenine to guanine at the 3234 nucleotide position of mitochondrial DNA(MtDNA) among Indonesian diabestic subjects"Diabetes Research and Clinical Practice. 58. 201-202 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 福家陽子: "パプアニューギニア(PNG)肥満者におけるβ_3アドレナリン受容体(β_3AR)遺伝子多型の解析"糖尿病. 45. S100 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 坂上元祥: "パプアニューギニア人におけるUCP-1、UCP-3遺伝子多型の解析"糖尿病. 45. S155 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Analysis of PPARγ2 and β_3-adorenergic receptor gene polymorphisms in obese subjects of Papua New Guinea(PNG)"Diabetes Research and Clinical Practice. 56. S73 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Analysis of gene polymorphisms associated with obesity and type 2 diabetes (DM) in obese subjects of Papua New Guinea(PNG)"Diabetes. 51. S407 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Austronesian-speaking people in Papua New Guinea have susceptibility to obesity and type 2 diabetes"Diabetes Care. 26. 955-956 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石原香織: "ジャワ島・バリ島住民における糖尿病関連遺伝子PPARγ2及びUCP1遺伝子多型の解析"糖尿病. 46. S202 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] W.Danawati: "Prevalence of Pro12Ala peroxisome proliferator activated receptorγ2(PPARγ2) missense mutation among Java ethnicity group"糖尿病. 46. S204 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 苗村綾: "パプアニューギニア(PNG)肥満者におけるアディポネクチン遺伝子SNP276の解析"糖尿病. 46. S256 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Fujimoto: "Low prevalence of tumor necrosis factor-α gene polymorphisms in the 5'promotor region (-238G/A and -308G/A) in subjects of Papua New Guinea"Diabetologia. 46. A144-A145 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Analysis of gene polymorphisms in "thrifty genes" in subjects of Papua New Guinea"Diabetologia. 46. A149 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石原香織: "インドネシア人におけるAdiponectin及びUCP3遺伝子多型の解析"第40回日本糖尿病学会近畿地方会プログラム講演抄録. 101 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ishihara: "Analysis of PPARγ2Pro12Ala and UCP-1(-112A→C) polymorphisms in Java and Bali islanders of Indonesia"Proceedings of 12th Japan-Korea Symposium on Diabetes Mellitus. 48 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Proceedings of Joint Meeting and Symposium Indonesia-Japan on Diabetes Mellitus Research"Yogyakarta Diabetes Center-Medical Faculty Gadjah Mada University. 10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 伊丹香里: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成12年度"神戸大学医学部保健学科検査技術科学専攻. 4 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 勝山登史江: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成12年度"神戸大学医学部保健学科検査技術科学専攻. 4 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 福家陽子: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成12年度"神戸大学医学部保健学科検査技術科学専攻. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 川辺麻衣子: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成13年度"神戸大学医学部保健学科検査技術科学専攻. 4 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 福田理恵: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成13年度"神戸大学医学部保健学科検査技術科学専攻. 4 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Perspectives of Diabetes in the New Millennium"Elsevier. 3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石原香織: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成14年度"神戸大学医学部保健学科検査技術科学専攻. 4 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤桃子: "神戸大学医学部保健学科検査技術科学専攻 卒業研究論文集 平成14年度"神戸大学医学部保健学科検査技術科学専攻. 4 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Analysis of gene polymorphism associated with susceptibility to obesity and type 2 diabetes : A study in Papua New Guinea"Proceedings of Joint Meeting and Symposium Indonesia-Japan on Diabetes Mellitus Research (Yogyakarta Diabetes Center-Medical Faculty Gadjah Mada University (Ed.)) (Yogyakarta). 1-10 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] W.Danawati: "Low prevalence of the substitution of adenine to guanine at the 3243 nucleotide position of mitochondrial DNA (MtDNA) among Indonesian diabestic subjects"Diabetes Research and Clinical Practice. 58. 201-202 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Itami: "Genetic background of diabetes and obesity in subjects of Papua New Guinea, PCR-RFLP analysis of gene mutation of glycogen synthase of skeletal muscle"Bulletin of Graduation Thesis in 2000, Department of Medical Technology, Faculty of Health Sciences, Kobe University School of Medicine, Kobe. 130-133 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Katsuyama: "Anthropological comparison of obesity-and diabetes-susceptible genes, Analysis of Pro12Ala polymorphism of PPARγ"Bulletin of Graduation Thesis in 2000, Department of Medical Technology, Faculty of Health Sciences, Kobe University School of Medicine, Kobe. 134-137 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Fuke: "Analysis of β_3 a adrenergic receptor (β_3 -AR) gene susceptible to obesity"Bulletin of Graduation Thesis in 2000, Department of Medical Technology, Faculty of Health Sciences, Kobe University School of Medicine, Kobe. 138-141 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Kawabe: "Analysis of UCP1 gene in subjects of Papua New Guinea with reference to obesity"Bulletin of Graduation Thesis in 2001, Department of Medical Technology, Faculty of Health Sciences, Kobe University School of Medicine, Kobe. 169-172 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] R.Fukuda: "Analysis of uncoupling protein 3 (UCP-3) gene susceptible to obesity"Bulletin of Graduation Thesis in 2001, Department of Medical Technology, Faculty of Health Sciences, Kobe University School of Medicine, Kobe. 173-176 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Absence of PPARγ2 Pro12Ala polymorphism in Papua New Guinea"Perspectives of Diabetes in the New Millennium (H.K.Lee, S.K.Kang, H.C.Lee, N.Hotta (Eds.)) (Elsevier, Singapore). 58-60 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ishihara: "Analysis of UCP-1 gene polymorphism in subjects of Indonesia"Bulletin of Graduation Thesis in 2002, Department of Medical Technology, Faculty of Health Sciences, Kobe University Medicine, Kobe. 180-183 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sato: "Analysis of Pro12Ala polymorphism of PPARγ2 gene in subjects of Indonesia"Bulletin of Graduation Thesis in 2002, Department of Medical Technology, Faculty of Health Sciences, Kobe University Medicine, Kobe. 184-187 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Sakaue: "Austronesian-speaking people in Papua New Guinea have susceptibility to obesity and type 2 diabetes"Diabetes Care. 26. 955-956 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Danawati W, Sakaue M, Taniguchi H.: "Low prevalence of the substitution of adenine to guanine at the 3243 nucleotide position of mitochondrial DNA among Indonesian diabetic subjects"Diabetes Res Clin Pract. 58(3). 201-202 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakaue M, Fuke Y, Katsuyama T, Kawabata M, Taniguchi H.: "Austronesian-speaking people in Papua New Guinea have susceptibility to obesity and type 2 diabetes."Diabetes Care. 26(3). 955-956 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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