| Project/Area Number |
12640574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
物質変換
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
YUJIRO Hayashi Tokyo University of Science,Faculy of Engineering ,Assistant Professor, 工学部, 助教授 (00198863)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | high pressure / Baylis Hillman reaction / Michael reacion / マイケル反応 / アルコール / α,β-不飽和カルボニル |
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| Research Abstract |
High pressure is one of the attractive factors for the promotion-of organic reactions, though it is not the common tool in organic synthesis owing to the expensive and huge machines for its realization. On the other hands, 1 the usual organic reactions are performed in organic solvents, which I cause the concern about the diffusion of organic solvents to atmosphere. AS the volume of water increases about 10 % when it freezes, it is expected to realize a high pressure when water freezes in an autoclave. In the present research, Michael reaction of alcohols with a, p-unsaturated: ketones and Baylis-Hillman reaction of methyl acrylate and aldehydes are found to be accelerated dramatically under the water-freezing induced pressure conditions, in which the environmentally friendly reaction Imedium, water, isused.
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