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A new function of myocardial myoglobin

Research Project

Project/Area Number 12670036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionYamagata University

Principal Investigator

TAKAHASHI Eiji  Yamagata University School of Medicine, Physiology, Associate Professor, 医学部, 助教授 (30206792)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsheart / oxygen / mitochondrion / image processing / hypoxia / ischemia / cardiac hypertrophy / diffusion / ミオグロビン / 活性酸素 / 再灌流
Research Abstract

Using a high-resolution spectrophotometric imaging system, relationship between intracellular oxygen supply and mitochondrial oxidative metabolism was examined in isolated single cardiomyocytes of the rat.
Specific questions were; whether intracellular diffusion of oxygen limits mitochondrial oxidative metabolism, 2. if so, how mitochondria deal with such heterogeneities of intracellular oxygen supply, and 3. what is the functional significance of cytosolic myoglobin. I found that cytosolic myoglobin certainly accelerates intracellular oxygen diffusion but diffusional oxygen supply may not always fully match the oxygen requirement of mitochondria particularly those located in the cell core. Thus, hypoxic core with metabolic inhibition (anoxic core) may be present in single cardiomyocytes with moderately elevated oxygen metabolism. I further demonstrated that this metabolic inhibition in the cell core is usually eliminated in mitochondria with intact respiratory control. Thus, in vivo cardiac myocytes can compensates for relatively slow intracellular oxygen diffusion.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Takahashi E, Endoh H, Doi K: "Visualization of myoglobin facilitated mitochondrial O_2 delivery in a single isolated cardiomyocyte"Biophys J. 78. 3252-3259 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi E, Endoh H, Ishikawa M, Kishi M, Doi K: "Effect of myoglobin inactivation on intracellular gradients of NADH fluorescence at critical mitochondrial oxygen supply"Appl Cardiopulmonary Pathophysiol. 9. 368-373 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Endoh H, Doi K, Takahashi E: "Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co^<2+>"Am J Physiol. 279. H2713-H2719 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋英嗣, 土井勝彦: "単一心筋細胞内部に形成される酸素欠乏領域"心筋の構造と代謝. 23. 213-218 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi T, Saito H, Hiroi M, Doi K, Takahashi E: "Effects of aging on inositol 1,4,5-triphosphate-induced Ca^<2+> release in unfertilized mouse oocytes"Mol Reprod Dev. 55. 299-306 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hirano H, Takahashi E, Doi K, Watanabe Y: "Role of intracellular calcium in fatigue in single skeletal muscle fibers isolated from the rat"Pathophysiol. 6. 211-216 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋英嗣, 土井勝彦(分担執筆): "Q&A運動と遺伝"大修館書店. 259 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi E, Endoh H, Ishikawa M, Kishi M, Doi K: "Effect of myoglobin inactivation on intracellular gradients of NADH fluorescence at critical mitochondrial oxygen supply"Adv Exp Med Biol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi E, Endoh H, Doi K: "Visualization of myoglobin facilitated mitochondrial O_2 delivery in a single isolated cardiomyocyte"Biophys J. 78. 3252-3259 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi E, Endoh H, Ishikawa M, Kishi M, Doi K: "Effect of myoglobin inactivation on intracellular gradients of NADH fluorescence at critical mitochondrial oxygen supply"Appl Cardiopulmonary Pathophysiol. 9. 368-373 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Endoh H, Doi K, Takahashi E: "Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co^<2+>"Am J Physiol. 279. H2713-H2719 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi T, Saito H, Hiroi M, Doi K, Takahashi E: "Effects of aging on inositol 1,4,5 triphosphate-induced Ca^<2+> release in unfertilized mouse oocytes"Mol Reprod Dev. 55. 299-306 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hirano H, Takahashi E, Doi K, Watanabe Y: "Role of intracellular calcium in fatigue in single skeletal muscle fibers isolated from the rat."Pathophysiol. 6. 211-216 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi E., Endoh H., Doi K.: "Visualization of myoglobin facilitated mitochondrial O_2 delivery in a single isolated cardiomyocyte"Biophys J. 78. 3252-3259 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi E., Endoh H., Ishikawa M., Kishi M., Doi K.: "Effect of myoglobin inactivation on intracellular gradients of NADH fluorescence at critical mitochondrial oxygen supply"Appl Cardiopulmonary Pathophysiol. 9. 368-373 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Endoh H., Doi K., Takahashi E.: "Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co^<2+>"Am J Physiol. 279. H2713-H2719 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋英嗣, 土居勝彦: "単一心筋細胞内部に形成される酸素欠乏領域"心筋の構造と代謝. 23. 213-218 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi T., Saito H., Hiroi M., Doi K., Takahashi E.: "Effects of aging on inositol 1,4,5-triphosphate-induced Ca^<2+> release in unfertilized mouse oocytes"Mol Reprod Dev. 55. 299-306 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hirano H., Takahashi E., Doi K., Watanabe Y.: "Role of intracellular calcium in fatigue in single skeletal muscle fibers isolated from the rat"Pathophysiol. 6. 211-216 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋英嗣, 土居勝彦(分担執筆): "Q&A 運動と遺伝"大修館書店. 259 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi E: "Visualization of myoglobin facilitated mitochondrial O_2 delivery in a single isolated cardiomyocyte."Biophys J. 78. 3252-3259 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 高橋英嗣: "分子生物学と運動 Q&A(分担執筆)"大修館書店(印刷中).

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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