• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Observation of the motion of a single molecule of neuronal nitric oxide synthase in the nucleus tractus solitarius

Research Project

Project/Area Number 12670071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionWakayama Medical Universtiy

Principal Investigator

MAEDA Masanobu  Wakayama Med. Univ., Physiology, Professor, 医学部, 教授 (80181593)

Co-Investigator(Kenkyū-buntansha) OWADA-MAKABE Kyoko  Wakayama Med. Univ., Physiology, Instructor, 医学部, 助手 (10203952)
TSUBOTA Yuji  Wakayama Med. Univ., Physiology., Instructor, 医学部, 助手 (50197761)
YUKAWA Kazunori  Wakayama Med. Univ., Physiology, Assist. Prof., 医学部, 講師 (20301434)
KUDO Hideaki  UOEH, Anatomy, Assistant Professor, 医学部, 講師 (40289575)
DOI Yoshiaki  UOEH, Anatomy, Associate Professor, 医学部, 助教授 (30258602)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥3,300,000 (Direct Cost: ¥3,300,000)
Keywordsnucleus tractus solitarii / nitric oxide / nitric oxide synthase / green fluorescent protein (GFP) / fluorescence / brain / circulation / gene / 孤束核
Research Abstract

In order to investigate the motion of a single molecule of neuronal nitric oxide synthase (nNOS) in the nucleus tractus solitarius (NTS), we tried gene (green fluorescent protein and nNOS) transduction into the NTS.
1. The simple methods for gene transduction in vivo into the brain using plasmid vector have not been developed. We microinjected green fluorescent protein (GFP) Fusion TOPO Cloning Vectors with cationic lipids (LipofextAMINE 2000) into the NTS and the hypoglossal nucleus, and removed the brain three, five, seven and ten days after the microinjection, and observed the fluorescence.
2. We could observe the fluorescence four brains microinjected out of five rats five days after the injection of plasmid vectors. The intensity of the fluorescence was the strongest five days after the injection. It is considered that the gene expression was the strongest five days after the transduction.
3. Next, we microinjected LacZ Vectors with cationic lipids into the brain. However, we could not observe beta-gal. It may be considered that the efficiency of gene transduction into the brain using a little large vector may be low.
4. Several new transfection drugs have been developed rapidly. We tried some new transfection drugs. We could observe the beta-gal using a certain new transfection drug.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (93 results)

All Other

All Publications (93 results)

  • [Publications] Nakai, M.: "Ceiebrai cortical inuscarinic cholinergic and N-niethyl-D-aspartate receptors mediate inciease in cxrtical blood flow elicited by chemical stimulation of periaqueductal gray matter"Neuroscience. 98(3). 449-457 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Washio, M.: "The isolation of Methicillin-resistant Staphylococcus aureus (MRSA) is a predictor for poor prognosis of the elderly patients with bacterial infection"International Medical Journal,. 7(2). 117-120 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maeda, M.: "International comparison of periodic health examination and medical privacy of workers"Journal of UOEH. 22(Suppl). 165-168 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue, M.: "Effect of differentwork styles on blood pressure"Journal of UOEH. 22(Suppl). 197-200 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yukawa, K.: "Impaired water-maze performance in mice lacking transcnntion factor CCAAT/enhancer-binding protein beta"Neuroscience Research Communications. 26. 59-67 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shi, W.: "The class IV semaphorin CD100 plays a nonredundunt role in the immune system: Defective B and T cell activation in CD100/sema4D-deficient mice"Immunity. 13. 633-642 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo, H.: "Dietary zinc deficiency decreases glutathione S-transferase expression in the rat olfactory epithelium"Journal of Nutrition. 130(1). 38-44 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tamura, M.: "Expression of profiin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells"J Am Soci Nephrology. 11(3). 423-433 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi, Y.: "Expression of a-calcitonin gene-related peptide in the enteric nervous system of rat small intestine"Neuroscience Letters. 285(1). 33-36 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchida, S.: "Transient expression of activin bA mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury"Bone. 27(1). 81-90 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushige, H.: "Synthesis and receptor sites of endothelin-1 in the rat liver vasculature"Anatomical Record. 259(4). 437-445 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto, O.: "Sweat gland toxicity induced by bis (tributyltin) oxide: An ultrastructural and X-ray microanalysis study"Archives of Toxicology. 74. 627-631 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishino, T.: "Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae"Chemical Senses. 26. 179-188 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Irie, M.: "Can conditioned histamine release occur under urethane anesthesia in guinea pigs?"Physiology & Behavior,. 72(4). 567-573 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murata, H.: "Input-output analysis of economic effect in nursing care insurance"Journal of Home Economics of Japan. 52(8). 729-736 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue, M.: "Attitudes toward reports on general health examination results by age, judgement of findings and work-styles"Journal of Occupational Health. 43(5). 281-283 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyonaga, H.: "Expressions of endothelin-1, fibronectin, and interleukin-1α of human umbilical vein endothelial cells under prolonged culture"Medical Electron Microscopy. 34(1). 41-53 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo, H.: "Expression of glutathione S-transferase in bisphenol A-treated rat liver"Environmental Sciences. 8(2&3). 256 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi, Y.: "Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells"Histology and Histopathology. 16(4). 1073-1079 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi, Y.: "Enhanced expression of ehdothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta"Histology and Histopathology. 17(1). 97-105 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto, O.: "Immunohistochemicai and ultrastructural observations of desmoplastic tncboepithelioina with a special reference to a morphological comparison with normal apocrine acrosyringeum"Journal of Cutaneous Pathology. 29(1). 15-26 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nara, S.: "Disorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension"Histology and Histopathology. 17(2). 427-436 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Dol, Y.: "Enhancement of immunoreactivity for endothelin-1 and endothelin converting enzyme-i in the cadmium-treated rat thoracic aorta"Virchows Archiv. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 前田正信: "アンチセンス法を用いて延髄孤束核のnNOSの遺伝子を制御した時の循環変化"自律神経. 37(3). 395-399 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 井上正岩: "液体塩素による凍傷事例からみた労働衛生スタッフの役割"産業衛生学雑誌. 42(6). 226-227 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 坪田裕司: "筋疾患マウスB6CBA/J-croの骨格筋小胞体分画における蛋白欠損とその生化学的性質に関する研究"和歌山医学. 51. 181-192 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 真壁恭子: "免疫不全マウスにおける胸腺細胞分化異常の解析と分化の異常"和歌山医学. 52(2). 163-170 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimoto, S.: "Roles of endothelin-1 in regulation of rat hepatic sinusoidal blood flow In: European Conference on Microcirculation, Fagrell, B.(ed.)"Monduzzi Editore, Bologna. 33-37 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi, Y.: "Vasocontraction in the rat superior mesenteric artery induced by hypoxia In: Proceedings of 7th World Congress for Microcirculation"Monduzzi Editore, Bologna. 323-327 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimoto, S.: "Vasoculogenesis during organogenesis and wound healing In: Proceeding of 7th World Congress for Microcirculation"Monduzzi Editore, Bologna. 347-351 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakai M., Maeda M.: "Cerebral cortical muscarinic cholinergic and N-methyl-D-aspartate receptors mediate increase in cortical blood flow elicited by chemical stimulation of periaqueductal gray matter"Neuroscience. 98(3). 449-457 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Washio M., Ishibashi N., Arai Y., KiyoharaC., Tanaka K., Maeda M., Fujishima M., Okayama M.: "The isolation of Methicillin-resistant Staphylococcus aureus (MRSA) is a predictor for poor prognosis of the elderly patients with bacterial infection"International Medical Journal. 7(2). 117-120 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maeda M., Inoue M., Washio M.: "International comparison of periodic health examination and medical privacy of workers"Journal of UOEH. 22(Supplement). 165-168 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue M., Maeda M.: "Effect of different work styles on blood pressure"Journal of UOEH. 22 (Supplement). l97-200 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yukawa K.,Tanaka T.,Toyomi A.,Tsuji S., Akira S., Iso. H.: "Impaired water-maze performance in mice lacking transcription factor CCAAT/enhancer-binding protein beta"Neuroscience Research Communications.. 26. 59-67 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shi W., Kumanogoh A, Watanabe C., Uchida J., Wang X., Yasui T., Yukawa K., Ikawa M., Okabe M., Yoshida K., Kikutani H.: "The class IV semaphorin CD100 plays a nonredundunt role in the immune system: Defective B and T cell activation in CD100/sema4D-deficient mice"Immunity. 13. 633-642 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo H., Doi Y., Nishino T., Nara S., Hamasaki K., Fujimoto S.: "Dietary zinc deficiency decreases glutathione S-transferase expression in the rat olfactory epithelium"Journal of Nutrition. 130 (1). 38-44 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tamura M., Tanaka H., Yashiro A., Osajima A., Okazaki M., Kudo H., Doi Y., Fujimoto S., Higashi K., Nakashima Y., Hirano H.: "Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells"Journal of the American Society of Nephrology. 11 (3). 423-433 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi Y., Peng H., Kudo H., Hamasaki K., Fujimoto S.: "Expression of a-calcitonin gene-related peptide in the enteric nervous system of rat small intestine"Neuroscience Letters. 285 (1). 33-36 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchida S., Doi Y., Kudo H., Furukawa H., Nakamura T., Fuiimoto S.: "Transient expression of activin bA mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury"Bone. 27 (1). 81-90 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushige H., Doi Y., Kudo H., Kayashima K., Kiyonaga H., Nagata T. Itoh H., Fujimoto S.: "Synthesis and recepto sites of endothelin-1 in the rat liver vasculature"Anatomical Record. 259(4). 437-445 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto O., Doi Y., Kudo H., Yoshizuka M., Fujimoto S.: "Sweat gland toxicity induced by bis (tributyltin) oxide: An ultrastructural and X-ray microanalysis study"Archives of Toxicology. 74. 627-631 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimoto S., Doi Y., Fukushige H., Kudo H., Nishino T.: "Roles of endothelin-1 in regulation of rat hepatic sinusoidal blood flow"In : European Conference on Microcirculation, Fagrell, B. (ed.), Monduzzi Editore, Bologna. 33-37 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishino T., Kudo H., Doi Y., Meada M., Hamasaki K., Morita M., Fujimoto S.: "Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae"Chemical Senses. 26 (2). 179-188 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Irie M., Meada M., Nagata S.: "Can conditioned histamine release occur under urethane anesthesia in guinea pigs?"Physiology & Behavior. 72 (4). 567-573 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murata H., Yamazaki S., Maeda M., Hisashige A.: "Input-output analysis of economic effect in nursing care insurance."Journal of Home Economics of Japan. 52 (8). 729-736 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue M., Minami Y., Masaki S., Kawashita T., Yoshioka K., Maeda M.: "Attitudes toward reports on general health examination results by age, judgment of findings and work-styles"Journal of Occupational Health. 43 (5). 281-283 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyonaga H., Doi Y., Karasaki Y., Arashidani K., Itoh H., Fujimoto S.: "Expressions of endothelin-1, fibronectin, and interleukin-1 α of human umbilical vein endothelial cells under prolonged culture"Medical Electron Microscopy. 34 (1). 41-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kudo H., Doi Y. & Fujimoto S.: "Expression of glutathione S-transferase in bisphenol A-treated rat liver"Environmental Sciences. 8(2&3). 256 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi Y., Kudo H., Nishino T., Kayashima K., Kiyonaga H., Nagata T., Nara S., Morita M., Fujimoto S.: "Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells"Histology and Histopathology. 16 (4). 1073-1079

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi Y., Kudo H., Nara S., Nishino T., Fujimoto S.: "Vasocontraction in the rat superior mesenteric artery induced by hypoxia"In : Proceedings of 7th World Congress for Microcirculation, Sydney, 2001, Monduzzi Editore, Bologna. 323-327 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujimoto S., Doi Y., Kudo H., Nshino T.: "Vasculogenesis during organogenesis and wound healing"In: Proceedings of 7th World Congress for Microcirculation, Sydney, 2001, Monduzzi Editore, Bologna. 347-351 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi Y., Kudo H., Nishino T., Yamamoto O., Nagata T., Nara S., Morita M., Fujimoto S.: "Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta"Histology and Histopathology. 17 (1). 97-105 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto O., Hamada T., Doi Y., Sasaguri Y., Hashimoto H.: "Immunohistochemical and ultrastructural observations of desmoplastic trichoepithelioma with a special reference to a morphological comparison with normal apocrin acrosyringeum"Journal of Cutaneous Pathology. 29 (1). 25-26 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nara S., Hachisuka K., Furukawa H., Doi Y., Kudo H., Fujimoto S.: "Disorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension"Histology and Histopathology. 17 (2). 427-436 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Doi Y., Kudo H., Yamamoto O. Hamasaki K., Yoshizuka M., Fujimoto S.: "Enhancement of immunoreactivity for endothelin-1 and endothelin converting enzyme-1 in the cadmium-treated rat thoracic aorta"Virchows Archi. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maeda M., Hirano H., Kudo H., Doi Y., Nakai M., Higashi K., Fujimoto S.: "Regulation of nNOS gene in the nucleus tractus solitarius using antisense method changes arterial blood pressure. (in Japanese ; English abstract)"The Autonomic Nervous System. 37 (3). 395-399 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inoue M., Maeda M.: "Role of occupational health staff considered in the case frostbite caused by exposure to liquid chlorine. (in Japanese; English abstract)"Sangyo Eiseigaku Zassi. 42 (6). 226-227 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsubota Y.: "Biochemical studies on the deficit protein in the sarcoplasmic reticulum fraction of skeletal muscle of B6CBA/J-cro mouse, a muscle disease mutant. (in Japanese ; English abstract)"The Journal of the Wakayama Medical Society. 51. 181-192 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Owada-Makabe K.: "Characterization of thymocytes in immunodeficient mice and induction beyond the arrest point. (in Japanese ; English abstract)"The Journal of the Wakayama Medical Society. 52 (2). 163-170 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishino, T.: "Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae"Chemical Senses. 26(2). 179-188 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Irie, M.: "Can conditioned histamine release occur under urethane anesthesia in guinea pigs ?"Physiology & Behavior. 72(4). 567-573 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Murata, H.: "Input-output analysis of economic effect in nursing care insurance"Journal of Home Economics of Japan. 52(8). 729-736 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Inoue, M.: "Attitudes toward reports on general health examination results by age, judgment of findings and work-styles"Journal of Occupational Health. 43(5). 281-283 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kiyonaga, H.: "Expressions of endothelin-1, fibronectin, and interleukin-1 α of human umbilical vein endothelial cells under prolonged culture"Medical Electron Microscopy. 34(1). 41-53 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kudo, H.: "Expression of glutathione S-transferase in bisphenol A-treated rat liver"Environmental Sciences. 8(2&3). 256 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Doi, Y.: "Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells"Histology and Histopathology. 16(4). 1073-1079 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Doi, Y.: "Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta"Histology and Histopathology. 17(1). 97-105 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto, O.: "Immunohistochemical and ultrastructural observations of desmoplastic trichoe pithe lioma with a special reference to a morphological comparison with normal apocrine acrosyringeum"Journal of Cutaneous Pathology. 29(1). 15-26 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nara, S.: "Disorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension"Histology and Histopathology. 17(2). 427-436 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Doi, Y.: "Enhancement of immunoreactivity for endothelin-1 and endothelin converting enzyme-1 in the cadmium-treated rat thoracic aorta"Virchows Archiv. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Doi, Y.: "Vasocontraction in the rat superior mesenteric artery induced by hypoxia. In : Proceedings of 7th World Congress for Microcirculation"Monduzzi Editore, Bologna. 323-327 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fujimoto, S.: "Vasculogenesis during organogenesis and wound healing In : Proceedings of 7th World Congress for Microcirculation"Monduzzi Editore, Bologna. 347-351 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakai,M.: "Cerebral cortical muscarinic cholinergic and N-methyl-1)-aspartate receptors mediate increase in cortieal blood flow elicited by chemical stimulation of periaqueductal gray matter."Neuroscience. 98(3). 449-457 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Washio,M.: "The isolation of Methicillin-resistant Staphylococcus aureus (MRSA) is a predictor for poor prognosis of the elderly patients with bacterial infection."International Medical Journal,. 7(2). 117-120 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maeda,M.: "International comparison of periodic health examination and medical privacy of workers."Journal of UOEH. 22(Suppl). 165-168 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue,M: "Effect cf different work styles on blood pressure."Journal of UOEH. 22(Suppl). 197-200 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yukawa,K.: "Impaired water-maze performance in mice lacking transcription factor CCAAT/enhancer-binding protein beta."Neuroscience Research Communications. 26. 59-67 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shi,W.: "The class IV semaphorin CD100 plays a nonredundunt role in the immune system : Defective B and T cell activation in CD100/sema4D-deficient mice."Immunity. 13. 633-642 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kudo,H.: "Dietary zinc deficiency decreases glutathione S-transferase expression in the rat olfactory epithelium"Journal of Nutrition. 130(1). 38-44 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tamura,M.: "Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells"J Am Soci Nephrology. 11(3). 423-433 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Doi,Y.: "Expression of a-calcitonin gene-related peptide in the enteric nervous system of rat small intestine"Neuroscience Letters. 285(1). 33-36 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Uchida,S.: "Transient expression of activin bA mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury"Bone. 27(1). 81-90 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukushige,H.: "Synthesis and receptor sites of endothelin-1 in the rat liver vasculature"Anatomical Record. 259(4). 437-445 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamoto,O.: "Sweat gland toxicity induced by bis (tributyltin) oxide : An ultrastructural and X-ray microanalysis study"Archives of Toxicology. 74. 627-631 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishino,T.: "Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae."Chemical Senses. 26. 179-188 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Doi,Y.: "Synthesis of calcitonin gene-realted peptide (CGRP) by rat arterial endothelial cells"Histology and Histopathology. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kiyonaga,H.: "Expressions of endothelin-1, fibronectin and interleukin-1a of human umbilical vein endothelial cells under prolinged culture"Medical Electron Microscopy. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 前田正信: "アンチセンス法を用いて延髄孤束核のnNOSの遺伝子を制御した時の循環変化"自律神経. 37(3). 395-399 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 井上正岩: "液体塩素による凍傷事例からみた労働衛生スタッフの役割"産業衛生学雑誌. 42(6). 226-227 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 坪田裕司: "筋疾患マウスB6CBA/J-croの骨格筋小胞体分画における蛋白欠損とその生化学的性質に関する研究."和歌山医学. 51. 181-192 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 真壁恭子: "免疫不全マウスにおける胸腺細胞分化異常の解析と分化の異常"和歌山医学. 52(2)(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujimoto,S.: "Roles of endothelin-1 in regulation of rat hepatic sinusoidal blood flow In : European Conference on Microcirculation, Fagrell, B.(ed.)"Monduzzi Editore, Bologna. 33-37 (2000)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi