Does streptococcal ADP ribosyl cyclase/cADPR hydrolase evokeIgdassswitch?
| Project/Area Number |
12670251
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
KARASAWA Tadahiro Kanazawa University, Graduate School of Medical Science, Assosiate Professor, 大学院・医学研究科, 助教授 (90251917)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | streptococcus pyogenes / cyclic ADP-ribose / NAD / レンサ球菌 / サイクリックADPリボース |
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| Research Abstract |
1. Distinct evidence of Ig class switch was not obtained when hybridoma cells were incubated with purified streptococcal ADP ribosyl cyclase/cADPR hydrolase.
2. The microbiologic status of streptococcal pharyngitis in pediatric outpatients was investigated. Children with clinical diagnosis of acute pharyngitis were enrolled. Of 360 specimens examined, 96 (26.7%) were beta hemplytic streptococci (BHS)-positive. The isolates were homogeneous for Lancefield's group and T antigen. Although group A was predominant (90 isolates, 93.8%), groups B (two isolates, 2.1%), C (one isolate, 1.0%), and G (three isolates, 3.1%) were also detected. It should be noticed that non-group A streptococci can not be detected with the currently used rapid antigen-detection tests. The results of T-serotyping suggest that human migration during summer vacation may provide an opportunity for streptococci to colonize in new hosts.
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Report
(3 results)
Research Products
(8 results)
