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Does streptococcal ADP ribosyl cyclase/cADPR hydrolase evokeIgdassswitch?

Research Project

Project/Area Number 12670251
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionKanazawa University

Principal Investigator

KARASAWA Tadahiro  Kanazawa University, Graduate School of Medical Science, Assosiate Professor, 大学院・医学研究科, 助教授 (90251917)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsstreptococcus pyogenes / cyclic ADP-ribose / NAD / レンサ球菌 / サイクリックADPリボース
Research Abstract

1. Distinct evidence of Ig class switch was not obtained when hybridoma cells were incubated with purified streptococcal ADP ribosyl cyclase/cADPR hydrolase.
2. The microbiologic status of streptococcal pharyngitis in pediatric outpatients was investigated. Children with clinical diagnosis of acute pharyngitis were enrolled. Of 360 specimens examined, 96 (26.7%) were beta hemplytic streptococci (BHS)-positive. The isolates were homogeneous for Lancefield's group and T antigen. Although group A was predominant (90 isolates, 93.8%), groups B (two isolates, 2.1%), C (one isolate, 1.0%), and G (three isolates, 3.1%) were also detected. It should be noticed that non-group A streptococci can not be detected with the currently used rapid antigen-detection tests. The results of T-serotyping suggest that human migration during summer vacation may provide an opportunity for streptococci to colonize in new hosts.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report

Research Products

(8 results)

All Other

All Publications (8 results)

  • [Publications] Karasawa, T.: "Epidemiological survey of β-hemolytic streptococci isolated from acute pharyngitis in a private pediatric practice"Jpn. J. Infect. Dis.. 54(2). 76-77 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 唐澤忠宏: "A群溶連菌"感染と抗菌薬. 4(4). 306-307 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Karasawa, T.: "Isolation of β-hemolytic streptococci (BHS) from acute pharyngitis in a private pediatric practice"Proceeding of 10^<th> conference of Japanese Lancefield Society. (発表予定). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Karasawa, T.: "Epidemiological survey of β-rhemplytic streptococci isolated irom acute pharyngitis irta priyate pedialric practice"Jpn. J. Infect. Dis.. 54(2). 76-77 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Karasawa, T.: "Isolation of β-hemolytic streptococci (BHS) from acute pharyngitis in a private pediatric practice"Proceeding of 10^<th> conference of Japanese Lancefield Society. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Karasawa, T.: "Epidemiological survey of β-hemolytic streptococci isolated from acute pharyngitis in a private pediatric practice"Jpn. J. Infect. Dis.. 54(2). 76-77 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 唐澤忠宏: "A群溶連菌"感染と抗菌薬. 4(4). 306-307 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Karasawa, T.: "Isolation of β-hemolytic streptococci (BHS) from acute pharyngitis in a private pediatric practice"Proceeding of 10^<th> conference of Japanese Lancefield Society. (発売予定). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2000-03-31   Modified: 2016-04-21  

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