| Project/Area Number |
12670315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | CHIBA UNIVERSITY |
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Principal Investigator |
NOGAWA Koji Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (40019584)
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| Co-Investigator(Kenkyū-buntansha) |
SUMAZONO Yasushi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (90302546)
OKUBO Yasushi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (00301094)
KOBAYASHI Etsuko Chiba University, Graduate School of Medicine, Lecture, 大学院・医学研究院, 講師 (80097427)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | The Jinzu River basin / Cadmium-exposure / Total cadmium intake / Renal tubular dysfunction / Proteinuria / Glucosuria / Proteinuria with glucosuria / Dose-response relationship |
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| Research Abstract |
We investigated among the inhabitants of the Jinzu River basin to demonstrate a dose-response relationship between renal dysfunction (proteinuria, glucosuria and proteinuria with glucosuria) and total cadmium (Cd) intake of individual subjects using logistic regression analysis and to calculate the allowable level of total Cd intake.
For the participants of 1967 and 1968 health examinations living in the Cd-polluted hamlets where the Cd concentration in rice was known, individual total Cd intake was calculated basing on the mean Cd concentration in rice and the history of residence in the living hamlet.
Partial regression coefficients of total Cd intake obtained from logistic regression analysis showed statistically significant in the both males and females. Namely the association between abnormality rates of urinary findings and total Cd intake was demonstrated.
The allowable levels of total Cd intake were calculated substituting the abnormality rates of urinary findings of the controls in 40, 50, 60 and 70 years old into the logistic regression formula. The allowable levels of total Cd intake were about 1.0-1.5g for both sexes and each age group using proteinuria with glucosuria. Considering that proteinuria with glucosuria is less sensitive than low molecule protein such as β_2-microglobulin which is an index of renal tubular dysfunction, it was suggested strongly that there were mostly no margin between the allowable level of total Cd intake obtained in this study and total Cd intake of the control subjects in Japan.
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