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CIGARETTE SMOKING AND GENDER-DIFFERENCES IN LUNG CANCER RISK: A MOLECULAR EPIDEMIOLOGY

Research Project

Project/Area Number 12670322
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

KIYOHARA Chikako  Graduate School of Medical Sciences, KYUSHU UNIVERSITY, Assistant Prof., 大学院・医学研究院, 講師 (00169963)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Yoichi  Graduate School of Medical Sciences, KYUSHU UNIVERSITY, Associate Prof., 大学院・医学研究院, 助教授 (20172356)
TANAKA Keitaro  Saga Medical University, Prof., 教授 (50217022)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordslung cancer / molecular epidemiology / gender-difference / cytochrome P4501A1 / glutathione S-transferase / polymorphism / GSTM1
Research Abstract

The most established etiologic risk factor for lung cancer is cigarette smoking. Differing distributions of histologic types of lung cancer between males and females may be associated with differences in smoking patterns, but this does not fully explain the observed gender differences. There is growing epidemiological evidence that, when smoking habits are comparable, women incur a higher risk (2-3 times) for small cell lung carcinoma than men. Molecular epidemiological studies have also indicated gender differences in the genetic and biochemical alterations in lung cancer.
We investigated polymorphisms of CYP1A1 (Msp I and IIe-Val) and GSTs (M1 and T1) in 152 lung cancer patients (male:female = 110:42). We also measured phenotypic activity of GYP1A1 (aryl hydrocarbon hydroxylase, AHH) in peripheral mitogen-treated lymphocytes. No gender-differences were observed between age-, cigarette dose- and season of the year-adjusted AHH activity/AHH inducibility (3-methylcholanthren-induced AHH activity/non-induced AHH activity). Proportion of CYP1A1 Msp I, CY1PA1 De-Val, GSTM1 and GSTT1 genotypes in males and females was not significantly different. Gender difference in aromatic DNA-adducts was not evident.
Whether lung cancer represents a different disease in women than in men is unclear. If the hypothesis regarding gender differences in genetic susceptibility to lung cancer proves to be true, education for reducing passive and active exposure to cigarette smoke must have a high priority for female's health.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 清原千香子, 大野良之: "喫煙による肺癌発生リスクの性差"癌の臨床. 47・5. 383-388 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C.Kiyohara, M.Washio: "Recognition of the deleterious effects of smoking among senior high school male students"Fukuoka Acta Medica. 92・12. 398-405 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C.Kiyohara, T.Shirakawa, J.M.Hopkin: "Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer"Environmental Health and Preventive Medicine. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyohara C., Ohno Y.: "Gender-diflerences in lung cancer risk and cigarette smoking"Gann no Rinsyo. 47. 383-388 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyohara C, Wahio M.: "Recognition of the deleterious effects of smoking among senior high school male students"Fukuoka Acta Med.. 92. 398-405 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kiyohara C., Shirakawa T., Hopkin JM.: "Genetic poiymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer"Environ Health Prevent Med.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 清原千香子, 大野良之: "喫煙による肺癌発生リスクの性差"癌の臨床. 47・5. 383-388 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Kiyohara, M.Washio: "Recognition of the deleterious effects of smoking among senior high school male students"Fukuoka Acta Medica.. 92・12. 398-405 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Kiyohara, T.Shirakawa, J.M.Hopkin: "Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer"Environmental Health and Preventive Medicine. (in press).

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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