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Comparative study on biomarkers of gastric cancer in residents of Japan, Dominican Republic, Tanzania, and China

Research Project

Project/Area Number 12670325
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionOita Medical University

Principal Investigator

AOKI Kazuo  Oita Medical University, Faculty of Medicine, Research Associate, MD, Ph.D, 医学部, 助手 (60201282)

Co-Investigator(Kenkyū-buntansha) SHIMAOKA Akira  Oita Medical University, Medical Information Center, Associate Prof, Ph.D, 医学情報センター, 助教授 (40136792)
MISUMI Junichi  Oita Medical University, Faculty of Medicine, Prof, MD, Ph.D, 医学部, 教授 (40109658)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
KeywordsGastric (Stomach) Cancer / General Residents / Chronic Atrophic Gastritis / Serum Pepsinogen / Serum Gastrin / Helicobacter Pylori Infection / Dominican Republic / Tanzania / 胃癌 / ペプシノーゲン / ガストリン / ヘリコバクタ・ピロリ抗体 / タンザニア / 胃癌死亡率 / 一般住民検診 / ヘリコバクタ・ピロリ / 日本 / 中国
Research Abstract

The aim of this study was to choose the factors related to biomarkers of gastric cancer, and to help establish more effective screening of gastric cancer. Health checkups were performed for residents of four countries; Japan, Dominican Republic, Tanzania, and China. The checkups consisted of questionnaires and testing of biomarkers of gastric cancer; the former including the property of subjects, investigated country, sex, age, educational status, etc., and life style, dietary habits, smoking habits, alcohol consumption, their living environment, past history for upper digestive disease, and subjective symptoms related to them whereas the latter included biomarkers of gastric cancer, serum pepsinogenes, serum gastrin, and antibody to Helicobacter pylori. Data of the questionnaire and testing of biomarkers of gastric cancer were analyzed by univariate and multivariate analysis.
Health checkups in Tanzania were performed among residents living in 2 counties, Kivaha and Hai, after getting … More approval of our research by the ethical committee for medical research in Tanzania on January and February in 2001. Volunteer subjects were collected from inhabitants living in two counties, which consisted of a total of 573 people ; 245 and 328 subjects were for male and female, respectively. On the other hands, health checkups in Dominican Republic were performed using a similar protocol as the research in Tanzania from November in 2001 to March in 2002. After having been approved by the ethical committee for medical research in the center of the friendship relations between Japan and Dominican Republic for medical education, volunteers in three cities cooperated in this research which consisted of 451 male and 764 female subjects; total 1215 subjects. Further, data of health checkups in Japan and China were analyzed with data in the abovementioned two countries. The number of subjects for male, female, and total were 323 & 536, 648 & 1093, 859 & 1741 people of general population in Japan and China, respectively. Data of the biomarkers of gastric cancer were analyzed among these four countries epidemiologically.
As population composition among four countries were much different, prevalence of chronic atrophic gastritis and infectious rate to Helicobacter pylori were compared among four countries after adjusting our investigated subjects to their populations and taking world population in 1995 as standard population. Prevalences of chronic atrophic gastritis were defined by serum pepsinogens, PG I <__= 70 (ug/1) & PG I / PG II <__= 3, which were 0.492, 0.117, 0.319, and 0.202 in Japan, China, Tanzania, and Dominican Republic, respectively, and which were much different among these four countries.
And then, logistic regression analysis was done in order to choose factors related to chronic atrophic gastritis which was considered as the precursor lesion gastric cancer. Still, variables were taken chronic atrophic gastritis as dependent one and investigated country, sex, age, subjective symptoms and past history related to upper digestive tract, smoking habits, alcohol consumption, serum gastrin level and infection to HP were chosen as significant variables, which were related to chronic atrophic gastritis. Odds ratio for chronic atrophic gastritis were 0.14, 0.62, and 0.38 times in China, Tanzania, and Dominican Republic, respectively, compared with risks in Japan. The risk for CAG was reduced in the three countries compared with risk in Japan. Conversely, as subjects got one year older than as serum gastrin level of them increased by 1 pg/ml, the risk to CAG increased by 1.3 and 0.6 percent, respectively. Besides, HP infection factor increased the risk of prevalence of CAG to the same extent as age and serum gastrin level factors. The risk was 5.3 times as much in CAG subjects compared with subjects without HP infection. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 青木一雄: "血清ペプシノーゲン法による一般集団における慢性萎縮性胃炎の実態-胃がんスクリーニングにおけるカットオフ値と要精検率"日本衛生学雑誌. 58(1). 117 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 青木一雄, Mercedes Castro, Mildre Disla, 三角順一: "ドミニカ共和国におけるヘリコバクタ・ピロリ細菌に対するIgG、およびIgM抗体陽性率"日本衛生学雑誌. 58(1). 149 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 青木一雄: "ドミニカ共和国とタンザニア連合共和国のヘリコバクタ・ピロリ感染率からみた慢性持続性感染に対する危機管理"平成14年度長崎大学熱帯医学研究所共同研究会(採択番号:14-B-5)「危機管理としての熱帯病対策」記録集. 78-82 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuo Aoki: "Epidemiology of Helicobacter pylori in the tropics"Joint International Tropical Medicine Meeting 2002、Abstract and Program. 80 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 青木一雄, Mercedes Castro, Paul Kihaile, 他: "日本, ドミニカ共和国、中国、タンザニア連合共和国の一般地域住民におけるヘリコバクタ・ピロリ感染率"日本公衆衛生雑誌. 49(10). 589 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 青木一雄, 三角順一, 趙文元, 他: "Prevalence of Helicobactor pylori infection in three areas with different gastric cancer mortality rate in Zanhuang Coutry in Chiana"International Symposium on Biology Cancer Prevention and Treatment. 30 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazui Aoki: "The actual conditions of the chronic atrophic gastritis in the general population by the serum pepsinogen method - Cut off levels and positivities in stomach cancer screening by serum pepsinogens -"Japanese Journal of Hygiene. 58(1). 117-117 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuo Aoki, Mercedes Castro, Mildre Disla, Junichi Misumi: "Positivities of 1gG and 1gM-antibodies to Helicobacter pylori in Dominican Republic"Japanese Journal of Hygiene. 58(1). 149-149 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuo Aoki: "The crisis management to chronic long life infection of Helicobacter pylori in Dominican Republic and the United Republic of Tanzania"Archives of Society for the study of " Preventive measures of tropical diseases as risk management" Joint research meeting (No. of adoption: 14-B-5) in 2002 in the Institute of Tropical Medicine, Nagasaki University. 78-82 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuo Aoki: "Epidemiology of Helicobacter pylori in the tropics"Joint International Tropical Medicine Meeting 2002, Abstract and program. 80-80 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuo Aoki, Mercedes Castro, Paul Kihaile, Junichi Misumi, etc.: "Infection rate to Helicobacter pylori in residents of Japan, Dominican Republic, Tanzania, and China"Japanese Journal of Public Health. 49(10). 589-589 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuo Aoki, Junichi Misumi, Wenyuan Zhao, etc.: "Prevalence of Helicobacter pylori infection in three areas with different gastric cancer mortality rate in Zanhaung County in China"International Symposium on Biology of Cancer Prevention and Treatment. 30-30 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 青木一雄: "血清ペプシノーゲン法による一般集団における慢性萎縮性胃炎の実態-胃がんスクリーニングにおけるカットオフ値と要精検率"日本衛生学雑誌. 58(1). 117 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 青木一雄, Mercedes Castro, Mildes Disla, 三角順一: "ドミニカ共和国におけるヘリコバクタ・ピロリ細菌に封するIgG、およびIgM抗体陽性率"日本衛生学雑誌. 58(1). 149 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 青木一雄: "ドミニカ共和国とタンザニア連合共和国のヘリコバクタ・ピロリ感染率からみた慢性持続性感染に対する危機管理"平成14年度長崎大学熱帯医学研究所共同研究会(採択番号:14・B・5)「危機管理としての熱帯病対策」記録集. 78-82 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kazuo Aoki: "Epidemiology of Helicobacter pylori in the tropics"Joint International Tropical Medicine Meeting 2002, Abstract and Program. 80 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 青木一雄, Mercedes Castro, Paul Kibaile, 他: "日本,ドミニカ共和国、中国、タンザニア連合共和国の一般地域住民におけるヘリコバクク・ピロリ感染率"日本公衆衛生雑誌. 49(10). 589 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 青木一雄 他: "タンザニア連合共和国の農村地域におけるヘリコバクタ・ピロリ感染率"第55回日本栄養・食糧学会西日本支部大会・第11回九州農村医学会総会合同大会抄録集. 48 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazuo Aoki: "Aspectos Clifnicos, Epidemiologicos y Diagnosticos de Helicobacter Pylori(スペイン語)"REPUBLICA DOMINICANA SECRETARIA DE ESTADO DE SALUD PUBLICA Y ASISTENCIA SOCIAL COMPLEJO HOSPITALARIO "DR.LUIS E.AYBAR"CENTRO DE EDUCASION MEDICA DE AMISTAD DOMINICO-JAPONESA. 37 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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