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Molecular preventive medicine on floching the onset and progression of enviromental Paramgul metals, pertisclarly mercay indiuced topicity

Research Project

Project/Area Number 12670327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionSaitama Medical School

Principal Investigator

YANAGISAWA Ihroyuki  Saitama Medical School, School of Medicin, Assistant professor, 医学部, 助教授 (10200536)

Co-Investigator(Kenkyū-buntansha) WADA Osamu  Saitama Medical School, Schol of Medicine, Profesor, 医学部, 教授 (60009933)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsHgCl_2 / acute renal failure / endothelin / nitric oxide / nitric oxide synthrse / 一酸化窒素分化酵素
Research Abstract

The present study was designed to elucidate the mechanisms responsible for the progression of HgC1_2-indnced acute renal failure(ARF). At the glomerulur level, there was endothelin(ET)-1 expression in glomerular mesangial cells, glomlar epithelial cells and juxtaglomernlar cells. However, the expression of endothelial type(e) nitric oxide synthase(NOS) and brain type(b) NOS was observed in glomerular endothelial cells and juxtaglomerular cells and in glomerular epithelial cells and macula densa cells, respectively. ET-1 expression was significantly increased in the HgCl_2-induced ARF model when compared to the control model. Inversely, the expression of eNOS and bNOS was significantly decreased in the HgCl_2-induced ARF model relative to the control model. It is known that ET-1 is a potent vasoconstrictor. Also, it is reported that nitric oxide(NO) derived from eNOS and bNOS is a vasodilator. An increase in ET-1 and a decrease in NO lead to a fall in glomerular filtration rate through a decrement in the ultrafiltration coefficient(Kf) due to glomerular mesangial and epithelial cell contraction and via a decrement in glomerular capillary plasma floW(Q_A) due to an increment in afferent alteriole resistance. Thus, it is suggested that the vasoconstrictor, ET-1 and the vasodilator NO play a crucial role in the progression of HgCl_2-induced ARF through a fall in Kf and Q_A. In addition, prior administration of the angiotensin receptor type 1 antagonist, TCV-116 inhibited ET-1 expression in the HgCl_2-induced ARF model, indicating that angiotensin II may be involved in the regulation of ET-1 expression

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 柳沢裕之: "Zm delicacy and hypertension"Trace Nutrients Res. 18. 67-71 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 柳沢裕之: "Enhanced expression of vsmNOS mRNA in glomentali from nets tithe unilstesol intently obstruction"Kidney Int. 57. 1502-1511 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 柳沢裕之: "L-Alginate treatment may prevent tubulointerslitial nephropathy ceused by germanium dioxide"Kidney Int. 57. 2275-2284 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 柳沢裕之: "Zim c deficiency further increases the enhanced expression of endothelin-1 in glomenli of the obstinated kidney"Kidney Int. 58. 575-586 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroyuki Yanagisawa: "Zinc deficiency and hypertensise"Trace Nutrients Reo. 18. 67-71 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroyuki Yanagisawa: "Enhanced expression of sumNOS mRNA inglomeroli from rsts with unilateral ureteral obstruction"Kidney Int. 57. 1502-1511 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroyuki Yanagisawa: "L-Arginine treatment may prevent tubulointeretitiol nephropathy caused by germanium dioxide"Kidney Int. 57. 2275-2284 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroyuki Yanagisawa: "Zinc deficiency further increases the enhanced expression of endothelin-1 in gomernli of the ofetracted kidney"Kidney Int. 58. 575-586 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 柳沢 裕之: "Zn deficiency and hypertension"Trace Nutrients Reo. 18. 67-71 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 柳沢 裕之: "Enhanced expression of vsm NOS mRNA in glomeruli from nets mid unilateral ureteral obstruction"Kidney clnt. 57. 1502-1511 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 柳沢 裕之: "L-Arginine treatment may prevent tubulointerstitial nephropathy cansel by germanium dioxide"Kidney clnt. 57. 2275-2284 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 柳沢 裕之: "Zinc deficiency further increases the enhanced expression of endothelin-1 in glomernli of the obstructed kidney"Kidney clnt. 58. 575-586 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 柳沢裕之: "Enhanced expression of vsmNOS mRNA in glomeruli from rat, with unilateral ureteral obstruction"Kidney Int. 57. 1502-1511 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 柳沢裕之: "L-Arginine treatment may prevent tubulointerstitial nephropathy caused by germanium dioxide"Kidney Int. 57. 2275-2284 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 柳沢裕之: "Zinc deficiency further increases the enhanced expression of endothelin-1 in glomeruli of the obstructed kidney"Kidney Int. 58. 575-586 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 柳沢裕之: "Zinc dificiency potentiates endothelin-1 gene expression in glomeruli of the obstructed kidney"Biomed Res Trace Elements. 11(3). 287-294 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 柳沢裕之: "Inhibitory effects of L-arginine treatment on the progression of GeO_2-induced tubulointerstitial nephropathy"Trace Nutrients Res. 17. 47-52 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 柳沢裕之: "Germanium and renal disorders-pathophysiology and prevention of the progression-"Biomed Res Trace Elements. 11(4). 333-334 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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