Study on the biological effects of the environmental arsenic expo-sure
| Project/Area Number |
12670336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Morioka Junior College, Iwate Prefectural University |
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Principal Investigator |
CHIBA Keiko Science of Living Dept. Morioka Junior Col lege, Iwate Prefectural Univ. Associate Professor, 助教授 (90197137)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Hiroshi Dept. of Preventive Medicine. Associate Professor St. Marianna Univ. School of Medicine, 助教授 (90081661)
TATSUMI Masanobu Health Administration Center, Professor Iwate Univ., 保健管理センター, 教授 (70137496)
IWANE Atsuko Science of Living Dept. Morioka Junior Col lege, Iwate Prefectural Univ. Associate Professor, 助教授 (00101543)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | inorganic arsenic / chronic arsenic poisoning / oxidative stress / DNA damage / marine product / hot spring water / 8-hydroxydeoxyguanosine / biological monitoring / 海藻類 / 発癌リスク / 海藻類摂取 |
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| Research Abstract |
Arsenic occurs in marine products, such as fish, shellfish and seaweed and also occurs in hot spring water. To evaluate the biological effects of these environmental arsenic exposures, we proposed to examine the urinary concentrations of arsenic species in 3 groups, a)Japanese ordinary healthy people, b)peosons who eat much marine products, c)persons who daily use the hot spring water. Inorganic arsenic(iAs), monomethyl arsenic(MA), dimethyl arsenic(DMA) and trimethyl arsenic(TMA) were detected in urine of healthy people and it was composed 70% more by TMA. IMD level that indicated as the sum of iAs and its metabolites (MA and DMA) was a useful marker of inorganic arsenic poisoning. Because higher levels of urinary IMD were detected in many healthy people who were not suffered from arsenic exposure, we have to consider its meaning in the future. Urinary arsenic levels of all species, especially DMA and TMA were significantly higher in the persons who eat much marine products than healthy people. It was suggested that much intake of marine products reflected on this result. To evaluate the role of oxidative stress in environmental arsenic and to establish the biological monitoring for arsenic, urinary 8-hydroxydeoxyguanosine(8-0HdG) levels of all persons in 3 groups were measured. Neither sex nor age differences were found in urinary 8-0HdG levels of healthy people. 8-0HdG levels in both persons who eat much marine products and who daily use the hot spring water were significantly higher than healthy people. However no significant correlation was shown between the urinary concentrations of arsenic species and 8-0HdG levels, such high level of 8-0HdG in 2 groups was suggested due to the environmental arsenic exposure.
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Report
(3 results)
Research Products
(17 results)
