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Study on the biological effects of the environmental arsenic expo-sure

Research Project

Project/Area Number 12670336
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionMorioka Junior College, Iwate Prefectural University

Principal Investigator

CHIBA Keiko  Science of Living Dept. Morioka Junior Col lege, Iwate Prefectural Univ. Associate Professor, 助教授 (90197137)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Hiroshi  Dept. of Preventive Medicine. Associate Professor St. Marianna Univ. School of Medicine, 助教授 (90081661)
TATSUMI Masanobu  Health Administration Center, Professor Iwate Univ., 保健管理センター, 教授 (70137496)
IWANE Atsuko  Science of Living Dept. Morioka Junior Col lege, Iwate Prefectural Univ. Associate Professor, 助教授 (00101543)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsinorganic arsenic / chronic arsenic poisoning / oxidative stress / DNA damage / marine product / hot spring water / 8-hydroxydeoxyguanosine / biological monitoring / 海藻類 / 発癌リスク / 海藻類摂取
Research Abstract

Arsenic occurs in marine products, such as fish, shellfish and seaweed and also occurs in hot spring water. To evaluate the biological effects of these environmental arsenic exposures, we proposed to examine the urinary concentrations of arsenic species in 3 groups, a)Japanese ordinary healthy people, b)peosons who eat much marine products, c)persons who daily use the hot spring water. Inorganic arsenic(iAs), monomethyl arsenic(MA), dimethyl arsenic(DMA) and trimethyl arsenic(TMA) were detected in urine of healthy people and it was composed 70% more by TMA. IMD level that indicated as the sum of iAs and its metabolites (MA and DMA) was a useful marker of inorganic arsenic poisoning. Because higher levels of urinary IMD were detected in many healthy people who were not suffered from arsenic exposure, we have to consider its meaning in the future. Urinary arsenic levels of all species, especially DMA and TMA were significantly higher in the persons who eat much marine products than healthy people. It was suggested that much intake of marine products reflected on this result. To evaluate the role of oxidative stress in environmental arsenic and to establish the biological monitoring for arsenic, urinary 8-hydroxydeoxyguanosine(8-0HdG) levels of all persons in 3 groups were measured. Neither sex nor age differences were found in urinary 8-0HdG levels of healthy people. 8-0HdG levels in both persons who eat much marine products and who daily use the hot spring water were significantly higher than healthy people. However no significant correlation was shown between the urinary concentrations of arsenic species and 8-0HdG levels, such high level of 8-0HdG in 2 groups was suggested due to the environmental arsenic exposure.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 網中雅仁, 山内博, 千葉啓子他: "日本人健常者の尿中ポルフィリン濃度に関する研究"臨床環境医学. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 千葉啓子: "砒素研究の新たな方向"岩手県立大学盛岡短期大学部研究論集. 4. 1-11 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sun, G., Yamauchi, H.et al.: "Progresses on researches of endemic arsenism in China : Population at risk, Intervention actions, and related scientific issues"Arsenic Exposure and Health Effects. IV. 79-85 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Saito, S., Yamauchi, H.et al.: "Quantitative determination of urinary 8-hydroxydeoxyguanosine(8-OHdG) by Using ELISA"Research Communications in Molecular Pathology and Pharmacology. 107. 39-44 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 齊藤 秀, 山内博他: "EHSA法による尿中8-ヒドロキシデオキシグアノシンの定量法"臨床検査. 44. 913-916 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岩根敦子: "リンゴ果実の肥大生育時期における部位別無機成分の動向"日本食品科学工学会誌. 47. 317-326 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Aminaka,M. et al.: "Study on the porphyrin levels in urine on the Japanese healthy people"Clinical Environmental Medicine. in Press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chiba,K.: "The new trend of arsenic study"Bulletin of Morioka Junior College, Iwate Prefectural University. 4. 1-11 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sun,G. et al.: "Progresses on researches of endemic arsenism in China : Population at risk, intervention actions, and related scientific issues"Arsenic Exposure and Health Effects. IV. 79-85 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Saito,S. et al.: "Quantitative determination of urinary 8-hydroxydeoxyguanisine(8-OHdG) by using ELISA"Research Communications in Molecular Pathology and Pharmacology. 107. 39-44 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Saito,S. et al.: "Study on quantitative method for 8-hydroxydeoxyguanisine in human urine using ELISA"Jounal of Medical Technology. 44. 913-916 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iwane A.: "Variation in mineral components of different parts of apple fruit during deveropment"Nippon Shokuhin Kagaku Kaisluy. 47. 317-326 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 千葉啓子: "砒素研究の新たな方向"岩手県立大学盛岡短期大学部研究論集. 4. 1-11 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sun, G., Yamauchi, H.et al.: "Progresses on researches of endemic arsenism in China : Population at risk, Intervention actions, and related scientific issues"Arsenic Exposure and Health Effects. IV. 79-85 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saito, S., Yamauchi, H.et al.: "Quantitative determination of urinary 8-hydroxydeoxyguanosine(8-OHdG) by Using ELISA"Research Communications in Molecular Pathology and Pharmacology. 107. 39-44 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 齊藤 秀, 山内博也: "ELISA法による尿中8-ヒドロキシデオキシグアノシンの定量法"臨床検査. 44. 913-916 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岩根敦子: "りんご果実の肥大生育時期における部位別無機成分の動向"日本食品科学工学会誌. 47. 317-326 (2000)

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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