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Soy isoflavone and other nutrient intake in relation to mortality from cancer and cardiovascular disease, and onset of menopause.

Research Project

Project/Area Number 12670349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionGifu University

Principal Investigator

NAGATA Chisato  Gifu University, Public Health, Assistant professor, 医学部, 助教授 (30283295)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Hiroyuki  Gifu University, Public Health, Professor, 医学部, 教授 (90073139)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordssoybeans / isoflavones / mortality / cancer / cardiovascular disease / menopause / cohort study / 死亡 / 胃がん
Research Abstract

Isoflavone, rich in soy products, have been reported to possess significant antioxidant, estrogenic and tyrosine kinase inhibitory activity. Therefore, soy product or isofllavone intake may prevent against cancer and cardiovascular disease. In addition, the estrogenicity of this substances may be related to the onset of menopause of women. The relationship between soy product and isoflavone intake to subsequent mortality from cancer and cardiovascular diseases was examined in participants in Takayama study. In 1992, a total of 13,355 male and 15,724 female residents in Takayama, Gifu, Japan, aged at least 35 years who were free of cancer, stroke, and ischemic heart disease completed a self-administered questionnaire including demographic characteristics, smoking and drinking habits, diet, exercise, and medical and reproductive histories. Diet including soy and fish intake was assessed by a validated semiquantitative food frequency questionnaire. In men, hazard ratios of the highest compared to the lowest quintile of total soy product intake were 0.89 for cancer mortality and 0.85 for cardiovascular disease mortality. Corresponding figures for women were 0.79 and 0.90, respectively, after controlling for age, total energy and other lifestyle variables. The relationship between soy product intake and the onset of menopause was assessed in women who were premenopausal at the entry into the Takayama study. Soy intake was not associated with the onset of menopause.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nagata et al.: "Ecological study of the association between soy profuctintalce and mortahty from cancer and heat disease in Japan"Int J Epidemiol. 29. 832-836 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata et al.: "Association of diet with the onset of menopause"Am J Epidemiol. 152. 863-867 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata et al.: "Soy product intake and hot flashes in Japanese women"Am J Epidemiol. 153. 790-793 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata et al.: "Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women"Eur J Clin Nutr. 55. 773-777 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata C et al.: "Association of diet with the onset of menopause in Japanese women"Am J Epidemiol. 152. 863-7. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata C et al.: "Ecological study of association between soy product intake and mortality from cancer and heart diseases in Japan"Int J Epidemiol. 29. 832-6 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata C et al.: "Soy product intake and hot flushes in Japanese women : results from a community-based prospective study"Am J Epidemiol. 153. 790-3 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata C et al.: "Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women"Eur J Clin Nutr. 55. 773-7 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C.Nagata et al.: "Soy product intake and hot flashes in Japanese women: results from a community-based prospective study"American Journal of Epidemiology. 153. 790-3 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Nagata et al.: "Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women"European Journal of Clinical Nutrition. 55. 773-777 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Nagata: "Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan"International Journal of Epidemiology. 29. 832-836 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] C.Nagata et al.: "Association of diet with the onset of menopause in Japanese women."American Journal of Epidemiology. 152. 863-867 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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