| Project/Area Number |
12670366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Sapporo Medical University School of Medicine |
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Principal Investigator |
MORI Mitsuru Sapporo Medical University, School of Medicine, Department of Public Health, Professor, 医学部, 教授 (50175634)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Satoru Sapporo Medical University, School of Medicine, Second Department of Internal Medicine, Assistant Professor, 医学部, 助手 (20295348)
SAITOH Sigeyuki Sapporo Medical University, School of Medicine, Second Department of Internal Medicine, Assistant Professor, 医学部, 講師 (60253994)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Impaired glucose tolerance / Diabetes Mellitus / Cancer / Cohort study / Survival analysis |
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| Research Abstract |
Purpose : By means of a cohort study, we evaluated the association between reduced glucose tolerance (RGT) and the occurrence of cancer.
Methods : A thousand nine hundred and eighty nine persons (908 males and 1,081 females) aged from 40 to 64 years from towns of Tanno and Sohbetsu in Hokkaido, Japan were randomly selected as the subjects of this study in 1977 and 1978, respectively. Measurements of total protein, albumin, uric acid, total cholesterol, β-lipoprotein, and trigliceride in serum as well as 50g oral glucose tolerance test were performed for the study subjects. They were followed-up until the end of 2002, and 590 persons (30.0%) among the study subjects, who attended mass-screening programs in July of 2001, were interviewed to obtain their past history. Hazard ratios (HRs) and their 95% confidence intervals (95%CIs) were estimated by Cox's proportional hazard model. In the follow-up period, 145 subjects (94 males and 51 females) were reported to have cancer. We analyzed the data not including any who had been observed for less than 5 years since the baseline survey.
Results : As a result, the age-adjusted HR for having cancer was significantly increased over quartiles of plasma glucose at 120 minutes after a 50g oral glucose load in the male subjects (p for trend, p=0.039). This result was not substantially modified even after adjusting for habits of smoking and drinking in addition to age (p for trend, p=0.044).
Conclusion : The relationship between RGT and increased risk of cancer may be etiological with several possible explanations for the biological mechanism. If so, it has been suggested that protection from impaired or reduced glucose tolerance may be important for reducing the risk of cancer. Further studies are necessary to evaluate the role of other possible factors working in conjunction with GTR such as increased energy intake and decreased physical activities.
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