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Forensic studies of brain vulnerability and resistance : Ischemia-induced dopamine and serotonin releases in the rat nucleus accumbens

Research Project

Project/Area Number 12670401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE, DEPARTMENT OF LEGAL MEDICINE

Principal Investigator

YOSHIMOTO Kanji  Kyoto Prefectural University of Medicine, Department of Legal Medicine, Assistant Professor, 医学部, 講師 (70111903)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsISCHEMIA / DOPAMINE / SEROTONIN / ANIMAL MODEL
Research Abstract

In the present study, we used in vivo brain micro dialysis to examine the effects of stimulations of ischemia and/or potassium on the release of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens (ACC) of anesthetized rats. Ischemia (Four vessels occlusion : 4VO) for 10 min increased DA and 5-HT release in the ACC 200-fold and 15-fold, respectively , in the first experiment. In second experiment, releases of DA and 5-HT in the ACC increased 350-400 % and 150-180 % by first and second K^+ stimulation, respectively, in the K^+-K^+ group. The 4VO treatment induced significant and massive increases of DA and 5-HT releases in the ACC, following K+ stimulation increased 5-HT release in the Ischemia-K^+ group compared with the K^+-K^+ group. Brain vulnerability was shown in the dopaminergic and serotonergic neurons in the same area of the ACC. These findings suggested that the ACC neurons showed a resistance to dysfunction in 10 min-ischemia and maintained neural function, monoamine synthesis and neurotransmitter releases within the transient neural damage.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] K.Yoshirroto et al.: "Changes in dopamine transporter and c-Fos expression in the nucleus accumbens ofalcohol-tolerance rats"Alcohol Cli Exp Res. 24. 361-365 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yoshimoto et al.: "Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of the amygdala"Neurochem Int. 37. 369-376 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda S.et al.: "Age-related dopamine deficiency in the mesostriatal dorarnine system of Zitter mutant rats"Neurosci. 2. 389-398 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeuchi, Y et al.: "Developxnental changes in cerebrospinal fluid concentration of monamine-related substances"J. Child Neurol. 15(4). 267-270 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Joyce JN et al.: "The zitter rat exhibits loss of D3 receptors with degeneration of the dopamine system"Neruo Report. 11(10). 2173-2175 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miura A, et al.: "The association between alcohol-drinkking behavior monoamine contents in the brain on stroke-prone"Cli Exp Hypertension. 20(4). 389 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yoshimoto et al.: "Doparrane and serotonin uptake inhibitors on the releases of dopamine and serotonin in the nucleus acccumbens"Mechanisms of Aqeing and Development. 122. 1707-1721 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yoshimoto et al.: "Electroacupuncture stimulation suppresses the increase in alcohol-drinking behavior in restricted rats"Alcohol. Cli. Exp. Res.. 25(6). 63S-65S (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Kawano et al.: "Histological changes in monoaminergic neurons of Long-Evanc Cinnamon rats"Brain Res.. 915. 25-31 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Sakuma et al.: "A possible role for BDNF, NT-4, and TrkB in thespinal cord and muscle of rat sublects to mechanical overload"Brain Res.. 907. 1-19 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 吉本 寛司 他: "Ageingとアルコール摂取行動"日本神経精神薬理学雑誌. 21. 355 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 吉本寛司: "アルコールと医学生物学"東洋出版. 40-43 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 吉本 寛司他: "アルコールと医学生物学"東洋出版. 195(16-20) (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshimoto et al: "Changes in dopamine transporter and c-Fos expression in the nucleus accumbens of alcohol-tolerance rats"Alcohol Cli. Exp. Res.. 24. 361-365 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshimoto et al: "Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of amygdala"Neurochem. Int.. 37. 369-376 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Ueda, K. Yoshimoto et al: "Age-related dopamine deficiency in the mesostriatl dopamine system of zitte mutant rats"Neuroscience. 2. 389-398 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Takeuchi, K. Yoshimoto et al: "Development changes in cerebrospinal fluid concentrations of monoamine-related substances"J. Child Neurol. 15 (4). 267-270 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.N. Joyce, K. Yoshimoto et al: "The zitter rat exhibits loss of D3 receptors with degeneration of the dopamine system"Neuro Rep. 11 (10). 2173-2175 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A. Miura, K. Yoshimoto et al: "The association between alcohol-drinking behavior and monoamine contents in the brain on stroke-prone SHR"Cli. Exp. Hypertension. 20 (4). 389 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshimoto et al: "Dopamine and serotonin uptake inhibitions on the releases of dopamine and serotonin in the nucleus accumbens of aged rats"Mechanism of Ageing and Development. 122. 1707-1721 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshimoto et al: "Electroacupuncture stimulation suppresses the increase in alcohol-drinking behavior in restricted rats"Alcohol. Cli. Exp. Res. 25 (6). 63s-65s (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Kawano, K. Yoshimoto et al: "Histological changes in monoaminergic neurons of Long-Evance Cinnamon rats"Brain Res. 915. 25-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Sakuma, K. Yoshimoto et al: "A possible role for BDNF, NT-4, and TrkB in the spinal cord and muscle of rat subjects to mechanical overload"Brain Res. 907. 1-19 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yoshimoto et al.: "Dopamine and serotonin uptake inhibitors on the releases of dopamine and serotonin in the nucleus accumbens"Mechanisms of Ageing and Development. 122. 1707-1721 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Yoshimoto et al.: "Electroacupuncture stimulation suppresses the increase in alcohol-drinking behavior in restricted rats"Alcohol.Cli. Exp. Res.. 25(6). 63s-65s (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Kawano et al.: "Histological changes in monoaminergic neurons of Long-Evanc Cinnamon rats"Brain Res.. 915. 25-31 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Sakuma et al.: "A possible role for BDNF, NT-4, and TrkB in thespinal cord and muscle of rat subjects to mechanical overload"Brain Res.. 907. 1-19 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 吉本 寛司他: "Ageingとアルコール摂取行動"日本神経精神薬理学雑誌. 21. 355 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 吉本 寛司他: "アルコールと医学生物学"東洋出版. 195(16-20) (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Yoshimoto et al.: "Changes in dopamine transporter and c-Fos expression in the nucleus accumbens ofalcohol-tolerance rats."Alcohol Cli Exp Res. 24. 361-365 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Yoshimoto et al.: "Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of the amygdala"Neurochem Int. 37. 369-376 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda S. et al: "Age-related dopamine deficiency in the mesostriatal dopamine system of Zitter mutant rats."Neurosci. 2. 389-398 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeuchi,Y et al: "Developmental changes in cerebrospinal fluid concentrations of monamine-related substances"J.Child Neurol. 15(4). 267-270 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Joyce JN et al.: "The zitter rat exhibits loss of D3 receptors with degeneration of the dopamine system."Neruo Report. 11(10). 2173-2175 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miura A, et al.: "The association between alcohol-drinkking behavior monoamine contents in the brain on stroke-prone."Cli Exp Hypertension. 20(4). 389 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉本寛司: "アルコールと医学生物学"東洋出版. 40-43 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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