• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Expression of Th2-specific chemokines in bronchial asthma

Research Project

Project/Area Number 12670415
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionThe University of Tokyo

Principal Investigator

ISHII Akira  The University of Tokyo, Graduate School of Medicine, Lecturer, 医学部・附属病院, 講師 (30272553)

Co-Investigator(Kenkyū-buntansha) HIRAI Koichi  The University of Tokyo, Graduate School of Medicine, Visiting Associate Professor, 大学院・医学系研究科, 客員助教授 (10156630)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsbronchial asthma / allergy / Th2 cells / chemokine / TARC / CCL17 / MDC / CCL22 / CCR4 / bronchial epithelial cells / ELISA
Research Abstract

We investigated the expression of Th2-specific chemolines, i. e., TARC (thymus and activation regulated chemokine) / CCL 17 and MDC (macrophage-derived chemokine) / CCL22 in bronchial asthma. Bronchial epithelium of asthmatics but not normal exhibited intense immunoreactivity with TARC. MDC immunoreactivty was only weak in both asthmatic and normal epithelium, and no difference of staining intensity was observed in both groups. Bronchial epithelial cell line cells liberated ng/ml quantities of TARC but not MDC in response to combined stimulation with IL-4/TNF-α. (Sekiya. T, et al. J. Immunol.65 : 2205-13, 2000)
TARC levels in sputum and serum in asthmatics was increased compared to those in normals. On the other hand, no significant difference was observed in MDC level in both group. (Seliya. T, et al. Allergy, in press)

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Sekiya, T., M.Miyamasu, A.Ishii, K.Hirai., et al.: "Inducible expression of a Th2-type CC Chemokine thymus and activation regulated chemokine (TARC) by human bronchial epithelial Cells"J. Immunol.. 165. 2205-2213 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohta, K., N.Yamashita, A.ishii, T.Miyamoto., et al.: "In vivo effects of apoptosis in asthma examined by a murine model"Int. Archi. Allergy Immunol.. 124(1-3). 259-261 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sekiya, T., H.Yamada, A.Ishii, K.Hirai., et al.: "Increased levels of a Th2-type CC Chemokines thymus and activation-regulated chemokine (TARC) in duced sputum and serum of asthmatics"Allergy. 57(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshimura, C., M.Yamaguchi, A.Ishii, K.Hirai., et al.: "Activation markers of human basophils : CD69 expression is strongly and preferentially induced of by IL-3"J. Allergy Clin. Immunol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sekiya T, M. Miyamasu, M. Imanishi, H. Yamada, T. Nakajima, M. Yamaguchi, T. Fujisawa, R. Pawankar, Y. Sano, K. Ohta, A. Ishii, Y. Morita, K. Yamamoto, K. Matsushima, O. Yoshie, and K. Hirai: "Inducible expression of a Th2-type CC chemokine thimus-and activation-regulated chemokine (TARC) by human bronchial epithelial cells"J. Immunol. 165. 2205-2213 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohta K, N. Yamashita, M. Tajima, T. Miyasaka, R. Kawashima, J. Nakano, H. Arioka, A. Ishii, T. Horiuchi, and T. Miyamoto: "In vivo effects of apoptosis in asthma examined by a murine model"Int. Archi. Allergy Immunol. 124 (1-3). 259-61 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sekiya T, H. Yamada, A. Morita, M. yamaguchi, A. Ishii, K. Matsushima, O. Yoshie, Y. Sano, K. Yamamoto, and K. Hirai: "Increased levels of a Th2-type CC Chemokines thymus and activation-regulated chemokine (TARC) in induced sputum and serum of asthmatics"Allergy. 57 (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshimura C, M. Yamaguchi, M. Iikura, S. Izumi, K. Kudo, H. Nagase, A. Ishii, T. Iwata, T. Igarashi, K. Yamamoto, and K. Hirai: "Activation markers of human basophils : CD69 expression is strongly and preferentially induced of by IL-e"J. Allergy Clin. Immunol. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakiya, T., M. Miyamasu, A.Ishii, K.Hirai., et al.: "Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine (TARC) by human bronchial epithelial cells"J. Immunol.. 165. 2205-2213 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohta, K., N.Yamashita, A.Ishii, T.Miyamoto., et al.: "In vivo effrcts of apoptosis in asthma examined by a murine model"Int. Archi. Allergy Immunol.. 124(1-3). 259-261 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sekiya, T., H.Yamada, A.Ishii, K.Hirai., et al.: "Increased levels of a Th2-type CC Chemokines thymus and activation-regulated chemokine (TARC) in induced sputum and serum of asthmatics"Allergy. 57(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimura, C., M.Yamaguchi, A.Ishii, K.Hirai., et al.: "Activation markers of human basophils : CD69 expression is strongly and referentially induced of by IL-3"J. Allergy Clin. Immunol.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] T Sekiya. et al.: "Inducible Expression of a Th2-Type CC Chemokine Thymus-and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells"The Journal of Immunology. 165. 2205-13 (2000)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi