Effects of cerebellar and globus pallidusstimulation in epilepsy
| Project/Area Number |
12670626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
HORI Ariyuki Kanazawa Medical University, Assistant Professor, 医学部, 講師 (80190221)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Tomoyasu Kanazawa Medical University, Instructor, 医学部, 助手 (80278118)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | cerebellar stimulation / anti-epileptic effects / kindling / globus pallidus stimulation / globus pallidus pars interna / thalamo-cortical pathway / status epilepticus / Kainic acid |
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| Research Abstract |
(1) Effects of cerebellar stimulation in kindled rats
Electrical stimulation of cerebellum was clinically introduced to control epilepsy and movements disorders in 1973. The efficacy of cerebellar stimulation on epilepsy and animal models of epilepsy, however, is still controversial. If cerebellar stimulation has antepileptic effects, transcranial magnetic stimulation, which is used clinically recently, might be avaable to suppress seizure. The aim of this study was to examine the antiepileptic effects of cerebellar stimulation.
Electrodes were implanted to basolateral amygdala and contralateral cerebellum, stereotaxically under anesthesia in SD rats. Cerebellar simulation was delivered once a day in Rats fully kindled. Total 40 times cerebellar stimuli were given. Rats showed elevated afterdischarge threshold and reduced seizure stage after cerebellar stimulation. These antiepileptic effects, however, were transient. Intermittent cerebellar stimulation could not be available treatment to suppress seizure permanently. Further studies are needed to apply the transcranial magnetic stimulation as treatment of seizure.
(2) Effects of globus pallidus pars interna (GPi) stimulation in status epilepticus(SE)
GPi has inhibitory input to thalamus, which is important pathway at secondary generalization in SE. The efficacy of GPi stimulation on SE was studied. If GPi has anti-epileptic effects especially in SE, new treatment for SE might be established. The aim of this study was to examine the anti-epileptic effects of GPi.
Electrodes were implanted to GPi in SD rats. SE was induced by Kainic acid injection intraperitoneally. Kainic acid injection induced SE with stage 5 seizure originated with limbic seizures. GPi stimulation was delivered continuously during SE GPi stimulation decreased severity of seizure stage and frequency of stage 5 seizures. GPi stimulation might be effective tosuppress the thalamo-cortical activation diring secondary generalized SE.
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Report
(3 results)
Research Products
(4 results)
