• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Parametric Imaging of Myocardial Perfusion Using Ultrasonic Microbubble Destruction

Research Project

Project/Area Number 12670675
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKagawa Medical University

Principal Investigator

OHMORI Koji  Kagawa Medical University, Second Department of Internal Medicine, Lecturer, 医学部・附属病院, 講師 (00263913)

Co-Investigator(Kenkyū-buntansha) NOZAKI Shiro  Kagawa Medical University, Second Department of Internal Medicine, Assistant Professor, 医学部・附属病院, 助手 (80243773)
MIZUSHIGE Katsufumi  Kagawa Medical University, Second Department of Internal Medicine, Associate Professor, 医学部, 助教授 (90166009)
SENDA Shoichi  Kagawa Medical University, Second Department of Internal Medicine, Professor, 医学部・附属病院, 教授 (30145049)
WADA Yoshihiro  Kagawa Medical University, Second Department of Internal Medicine, Assistant Professor, 医学部・附属病院, 助手 (00314930)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsmicrobubble / myocardial perfusion / Myocardial contrast echocardiography / intermittent imaging / ultrasound / dipyridamole / microsphere / 心筋コントラスロエコー法 / 心筋内血流速度 / 心筋内血管容積 / 心筋血流量 / ハーモニックパワードプラ法 / 超音波コントラスト剤
Research Abstract

We devised a new intermittent imaging employing an ultrasound pulsing sequence that utilized ultrasonic microbubble destruction to quantitate myocardial blood flow (MBF).
We devised a new intermittent imaging employing an ultrasound pulsing sequence that utilized ultrasonic microbubble destruction to quantitate myocardial blood flow (MBF). We found that abrupt shortening of ultrasound pulsing interval (PI) in myocardial contrast echocardiography during intravenous microbubble infusion produces a decay of contrast intensity (CI) along frame number (f), which fit tell to a decay function SI=α×exp(-β×f)+γ. Our study in vitro using a flow model revealed that α and β thus obtained reflect flow transit velocity. Subsequently, we performed an in vivo study in which MBF in rats was successfully quantitated with the new parameters derived from this formula. By defining myocardial velocityas Vel=1/(β/HR), where HR is heart rate, and myocardial blood volume as Vol=α+γ, MBF is determined as VelxVol … More = [1/(β/HR)](α+γ). MBF thus determined exhibited a close correlation with microsphere-derived MBF at baseline, during pharmacological hyperemia, and during coronary stenoses.
Finally, we validated this method in clinical settings. The parameters obtained with harmonic power Doppler and commercially available microbubbles for clinical use, we examined the usefulness of the pulsing sequence. The extent of CI decay produced by PI shortening from 1:10 to 1:1 end-systolic ECG trigger during intravenous microbubble infusion exhibited a similar decay. The extent of CI decay:α/(α+γ) was found useful in quantification of coronary vasodilator reserve, which allowed defection of significant coronary stenoses with a sensitivity of 93 % and a specificity of 85%. In addition, multi-frame trigger that emitted a burst of 4 rapid pulses was found useful in standardizing microbubble concentration in the myocardium. The time duration from the beginning of segmental myocardial opacification after bolus microbubble injection to the burst in which the last pulse resulted in no opacification was correlated with myocardial blood volume, and thus the myocardial viability evaluated by 201-thallium uptake in infarcted segments inpatients. Less

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Akira Oshita: "A Simple Pulsing Pattern in Contrast Echocardiography Enables to Measure Myocardial Blood Flow in Rats"Ultrasound in Medicine and Biology. 28(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazushi Yukiiri: "The Time Domain Index : A Novel Method for Assessing Relative Myocardial Blood Volume After Intravenous Contrast Injection"Journal of American Society of Echocardiography. 15(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuichiro Takagi: "Detection of Coronary Steal Phenomenon During Pharmacological Hyperemia by Harmonic Power Doppler Employing a Simple Pulsing Sequence in Patients"Journal of the American College of Cardiology. 37・2. 423A (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Oshita: "A Contrast Echocardiographic Method Employing a Simple Pulsing Sequence and a High Frequency Transducer to Measure Myocardial Flow in the Rats"Circulation. 102・18. II-453 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Oshita: "A simple Pulsing pattern in Contrast Echocardiography Enables to Measure Myocardial Blood Flow in Rats"Ultrasound in Medicine and Biology. 28 (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazushi Yukiiri: "The Time Domain Index: A Novel Method for Assessing Relative Myocardial Blood Volume After Intravenous Contrast Injection"Journal of American Society of Echocardiography. 15 (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuuichiro Takagi: "Detection of Coronary Steal Phenomenon During Pharmacological Hyperemia by Harmonic Power Doppler Employing a Simple Pulsing Sequence in Patients"Journal of the American College of Cardiology. 37-2. 423A (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Oshita: "A Contrast Echocardiographic Method Employing a Simple Pulshing Sequence and a High Frequency Transducer to Measure Myocardial Flow in the Rats"Circulation. 102-18. II-453 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Oshita: "A Simple Pulsing Pattern in Contrast Echocardiography Enables to Measure Myocardial Blood Flow in Rats"Ultrasound in Medicine and Biology. 28・(In Press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazushi Yukiiri: "The Time Domain Index : A Novel Method for Assessing Relative Myocardial Blood Volume After Intravenous"Journal of American Society of Echocardiography. 15・(In Press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Youichiro Takagi: "Detection of Coronary Steal Phenomenon During Pharmacological Hyperemia by Harmonic Power Doppler Employing a Simple Pulsing Sequence in Patients"Journal of the American College of Cardiology. 37・2. 423A (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akira Oshita: "A Contrast Echocardiographic Method Employing a Simple Pulsing Sequence and a High Frequency Transducer to Measure Myocardial Flow in the Rats"Circulation. 102・18. II-453 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 大下哲: "Quantification of Myocardial Blood Flow Based on the Observation of Contrast Intensity Decay Following the Abrupt Shortening of Pulsing Interval"Japanese Circulation Journal. 64巻 Supple I. 135 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 高木雄一郎: "ATP負荷心筋コントラストエコー法による冠血流スチール現象の検出に基づく有意冠狭窄の診断"Journal of Cardiology. 36巻 Supple I. I-224 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Akira Oshita: "A Contrast Echocardiographic Method Employing a Simple Pulsing Sequence and a High Frequency Transduce to Measure Myocardial Flow in the Rats : Validation by Comparing with Microsphere Method"Circulation. 102巻・18号 Supple II. II-453 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大下哲: "経静脈心筋コントラストエコー法による血管容積と心筋血流速度の分離評価に基づくラット心筋血流量の計測-マイクロスフェア法との比較-"Journal of Cardiology. 36巻 Supple I. I-221 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yuichiro Takagi: "Detection of Coronary Steal Phenomenon During Pharmacological Hyperemia by Harmonic Power Doppler Employing a Simple Pulsing Sequence in Patients with Coronary Stenosis"The Journal of the American College of Cardiology. 37巻・2号Supple A. 423A (2001)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi