| Project/Area Number |
12670682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
MINAGOE Shinichi Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90190694)
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| Co-Investigator(Kenkyū-buntansha) |
TEI Chuwa Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (10163891)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Doppler echocardiography / contrast echocardiography / intramural small coronary artery / L-NAME treated pig / ATP infusion / myocardial ischemia / microcirculation / Doppler eduocardio-graphy / smallcaronary artery / L-NAME / Cortrast eduo / Mgocardial ischemia / Doppler echocardiography / small coronary artery / Contrast echo / Myocardial ischemia |
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| Research Abstract |
The effect of the intramyocardial small coronary artery stenosis on the regional perfusion in the myocardium: Experimental study in L-NAME treated pigs using Doppler and myocardial contrast echocardiography
Although the structural abnormalities of the intramyocardial small coronary artery are proposed, its role for regional myocardial perfusion is unknown. We previously reported that transthoracic Doppler echocardiography using a high frequency transducer is a technique which can detect the stenotic lesion in the intramyocardial small coronary artery in patients with hypertrophic cardiomyopathy. However, the relation of the stenosis of the small coronary artery and its role for microcirculation is controversial because of the methodological limitations. On the other hand, myocardial contrast echocardiography is method which demonstrates the microcirculatory dysfunction (downstream of the small coronary artery) as changes of the density. L-NAME treated pig is an animal model which has a
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stenosis of the small coronary artery without epicardial coronary artery stenosis. We hypothesized that the upstream stenosis of the small coronary artery would affect the regional perfusion disturbance, and examined whether the intrammyocardial small coronary artery stenosis by color Doppler echocardiography can affect the myocardial perfusion abnormalities by myocardial contrast echocardiography during ATP infusion in L-NAME treated open chest pigs.
Prediction of Doppler echocardiographic demonstration of the small coronary artery stenosis was demonstrated in 3 of 5 pigs after L-NAME treated pigs. Myocardial hypoperfusion downstream of the small coronary artery stenosis was demonstrated by myocardial contrast echocardiography during peripheral ATP infusion in 2 of 4 pigs. Our hypothesis of small coronary artery stenosis has an important role for producing the regional myocardial hypoperfusion was partially obtained in this study while further confirmation of the validity is needed in the future. Less
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