| Project/Area Number |
12670713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
ABE Haruhiko UOEH, School of Medicine, Assistant Professor, 医学部, 講師 (70231967)
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| Co-Investigator(Kenkyū-buntansha) |
KOHSHI Kiyotaka UOEH, School of Medicine, Research Associate, 医学部, 助手 (90195660)
NAGATOMO Toshihisa UOEH, School of Medicine, Associate Professor, 医学部, 助教授 (50258604)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Syncope / head-up tilt test / orthostatic training / neurocardiogenic / heart rate variability / follow-up / head-up-tilt試験 / orthostatic self-training / ホルター心電図 / 神経調整性失神 / head-up tilt試験 / Tilt training |
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| Research Abstract |
The purpose of the present study was to investigate the efficacy of home orthostatic self-training program for the prevention of tilt-induced neurocardiogenic syncope. A total of 46 neurocardiogenic syncopal patients, who had experienced spontaneous syncope and were diagnosed by head-up tilt testing (80 degrees for 30 min), were included in the present study. All patients were treated with home orthostatic self-training alone for 30 minutes without any drug therapy and reevaluated within 4 weeks with the same protocol of initial tilt testing. Reevaluated head-up tilt testing could not induce the syncope after the home orthostatic self-training. Heart rate variability after the training showed significant decrease of L/H ratio at the early stage of upright position compared to that before training. All patients were successfully treated with home orthostatic self-training alone without any symptoms such as syncope or presyncope during the long-term follow-up of mean 11 months. We concluded that home orthostatic self-training is a very effective, safe and useful therapeutic option for the prevention of tilt-induced neurocardiogenic syncope.
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