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Pathogenesis on Viral Encephalitis/Encephalopathy

Research Project

Project/Area Number 12670745
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNagoya University

Principal Investigator

MORISHIMA Tsuneo  Nagoya University, School of Medicine, Professor, 医学部, 教授 (90157892)

Co-Investigator(Kenkyū-buntansha) KIMURA Hirosi  Nagoya University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (30303621)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsacute encephalitis / acute encephalopathy / herpes simplex virus / neonatal herpes / influenza virus / measles virus / SSPE / cytokines / EBウイルス / HHV-6 / インフルエンザ / エンテロ71脳炎 / インフルエンザ脳炎 / インフルエンザ脳症 / 単純ヘルペス脳炎 / E-セレクチン
Research Abstract

Annual Incidence of acute encephalitis/encephalopathy among children is approximately 1,000-2,000 cases. The aim of this study was to investigate epidemiology, clinical features, virological studies, pathogenesis, treatment and prevention on 1. herpes simplex encephalitis, 2. neonatal herpes, 3. influenza associated encephalopathy, 4. SSPE 5. others diseases.
1. Herpes simplex encephalitis : We have shown that the relapse of the illness occurred frequently among children and insufficient treatment with antiviral agents was one of the important factors of the relapse.
2. Neonatal herpes : In cases with HSV type 2 infection, significantly higher amount of viral DNA was demonstrated in CSF, and CNS involvement occurred more frequently than type 1. Moreover, relapse also occurred frequently in type 2 infection.
3. AH3 subtype of influenza virus causes the acute encephalopathy more frequently in young children than the other subtypes of the virus. High concentration of cytokines was found in sera and CSF and damage of vascular endothelial cells was demonstrated.
4. In the treatment of SSPE, intraventricular injection of interferon alpha and ribavirin was done under the permission of Ethical Committee of Nagoya Univ., and growth inhibitory effects of the virus was demonstrated.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Ito Y, et al.: "Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir"Clinical Infectious Diseases. 30(1). 185-187 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morishima T, et al.: "Encephalitis and encephalopathy associated with an influenza epidemic in Japan"Clinical Infectious Diseases. 35. 512-517 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kimura H, et al.: "Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2"Journal of Medical Virology. 67. 349-353 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morishima T, et al.: "Natural killer cell proliferation and circulating cytokines in patients with bilateral basal ganglia calcification"European Journal of Neurology. 9. 521-525 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawada J, et al.: "Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7"Ped Infect Dis J. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hara S, et al.: "Combination therapy with intraventricular interferon-a and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay"Brain Dev. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito Y, et al.: "Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir"Clinical Infectious Diseases. 30(1). 185-187 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morishima T, et al.: "Encephalitis and encephalopathy associated with an influenza epidemic in Japan"Clinical Infectious Diseases. 35. 512-517 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kimura H, et al.: "Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2"Journal of Medical Virology. 67. 349-353 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morishima T, et al.: "Natural killer cell proliferation and circulating cytokines in patients with bilateral basal ganglia calcification"European Journal of Neurology. 9. 521-525 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawada J, et al.: "Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7"Pediatric Infectious Disease Journal. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hara S, et al.: "Combination therapy with intraventricular interferon-a and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay"Brain and Development. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawada J, et al.: "Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7."Ped Infect Dis J. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Morishima T, et al.: "Encephalitis and encephalopathy associated with an influenza epidemic in Japan."Clinical Infectious Diseases. 35. 512-517 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kimura H, et al.: "Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2."Journal of Medical Virology. 67. 349-353 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Morishima T, et al.: "Natural killer cell prollferation and circulaiing cytokines in patients with bilat eral basal ganglia calcification."European Journal of Neurology. 9. 521-525 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hara S, et al.: "Combination therapy with intraventricular interferon-a and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR"Brain Dev. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito Y.Kimura H.Hara S.Kido S.Ozaki T.Nishiyama Y.Morishima T: "Investigation of varicella-zoster virus DNA in lymphocyte subpopulations by quantitative PCR assay"Microbial Immunol.. 45(3). 141-148 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Togashi T. Matsuzono Y.Morishima T.Narita M.: "Acute encephalitis-encephalopathy during influenza epidemics in Japanese children"Options for the Control of Influenza. Excerpta Medica. 1219. 609-613 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 森島 恒雄: "インフルエンザ脳炎・脳症の疫学と発症・病態"臨床検査. 46(2). 157-161 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 安藤嘉浩, 小出照子, 栄 賢司, 木村 宏, 森島恒雄: "中枢神経合併症を伴うエンテロウイルス71感染"小児科臨床. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kasai T.,Togashi M.and Morishima T.: "Encephalopathy associated with influenza epidemics."Lancet. 355. 1558-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 森島恒雄: "αヘルペスウイルスの本邦臨床統計"日本臨床. 58(4). 845-50 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kimura H.,Kido S.,Ozaki T.,Tanaka N.,Ito Y.,Williams RK,and Morishima T.: "Comparison of quantitations of viral load in varicella and zoster."J.Clin.Microbilol.. 38(6). 2447-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ito Y.,Kimura H.,Yabuta Y.,Ando Y.,Murakami T.,Shiomi M.and Morishima T.: "Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir."Clin.Infect.Dis.. 30(1). 185-7 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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