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INHIBITION OF PANCREATIC β-CELLS DESTRUCTION IN NONOBESE DIABETIC(NOD) MICE BY THE NEW IMMUNO-SUPPRESSIVE REAGENT FTY720 BEFORE AND AFTER ONSET OF DIABETES

Research Project

Project/Area Number 12670757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionEhime University

Principal Investigator

KIDA Kaichi  EHIME UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS, PROFESSOR, 医学部, 教授 (80093409)

Co-Investigator(Kenkyū-buntansha) KAINO Yukikazu  EHIME UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS, ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (00204313)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordstype 1 diabetes mellitus / FTY720 / non-obese diabetic mice (NOD) mice / insulitis / prevention / after onset of diabetes / pancreatic β-cell / immunotherapy
Research Abstract

Type 1 diabetes mellitus is known to result from chronic progressive islet inflammation and concomitant preferential β-cell destruction. The NOD mouse is an excellent animal model of spontaneous type 1 diabetes mellitus that shows many of the characteristics of humen type 1 diabetes mellitus. FTY720 is a chemical substance derived by modifying an immunosuppressive metabolite, ISP-1, from Isaria sinclairii, an ascomycete. Accelerated lymphocyte homing and apoptosis contribute to potent immunosuppressive effects of this drug.
This study has demonstrated that FTY720 prevents diabetes in NOD mice and prolongs the survival period after onset of the disease, indicating that treatment with FTY720 would be an effective strategy for protecting pancreatic β-cells from inflammatory insulitis in human type 1 diabetes mellitus.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report

Research Products

(11 results)

All Other

All Publications (11 results)

  • [Publications] T.Ito, K.Nakamura, E.Umeda, Y.Kaino, H.Hirai, K.Kida, G.Mimura: "Familial predisposition of type 1 diabetes mellitus in Japan, a country with low incidence. -Japan Diabetes Society Data Committee for Childhood Diabetes-"Journal of Pediatric Endocrinology & Metabolism. 14(Suppl 1). 589-595 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Kohno, Y.Kobashiri, Y.Sugie, S.Takai, K.Watabe, Y.Kaino, K.Kida: "Antibodies to food antigens in Japanese patients with type 1 diabetes mellitus"Diabetes Research and Clinical Practice. 55. 1-9 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Hirai, Y.Kaino, T.Ito, K.Takemoto, K.Kida: "Early detection of infantile pre-type 1 diabetes case with transient hyperglycemia"Diabetes Research and Clinical Practice. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Ito, K. Nakamura, E. Umeda, Y. Kaino, H. Hirai, K. Kida, G. Mimura: "Familial predisposition of type 1 diabetes mellitus in Japan, a country with low incidence. -Japan Diabetes Society Data Committee for Childhood Diabetes-."Journal of Pediatric Endocrinology & Metabolism. 14 (Suppl. 1). 589-595 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. kohno, Y. Kobashiri, Y. Sugie, S. Takai, K. Watabe, Y. Kaino, K. Kida: "Antibodies to food antigens in Japanese patients with Type 1 diabetes mellitus"Diabetes Research and Clinical Practice. 55 (1). 1-9 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Hirai, Y. Kaino, T. Ito, K. Takemoto, K. Kida: "Early detection of infantile pre-type 1 diabetes case with transient hyperglycemia"Diabetes Research and Clinical Practice. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 平井洋生, 戒能幸一: "NODマウスの糖尿病発症の成因と糖尿病発症予防に関する実験的研究"愛媛医学. 19. 487-494 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Kohno, Y.Kobashiri, Y.Sugie, S.Takai, K.Watabe, Y.Kaino, K.Kida: "Antibodies to food antigens in Japanese patients with type 1 diabetes mellitus"Diabetes Research and Clinical Practice. 55. 1-9 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 戒能幸一: "(II.1型糖尿病9.将来の展望)小児・思春期糖尿病管理の手引き.日本糖尿病学編"南江堂. 94-98 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 平井洋生,成能幸一,伊藤卓夫,貴田嘉一: "NODマウスの糖尿病発症の成因と糖尿病発症予防に関する実験的研究"愛媛医学. 19(4). 487-494 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 日本糖尿病学会小児糖尿病委員会: "小児・思春期糖尿病管理の手びき"南江堂. 228 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-03-31   Modified: 2016-04-21  

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