INHIBITION OF PANCREATIC β-CELLS DESTRUCTION IN NONOBESE DIABETIC(NOD) MICE BY THE NEW IMMUNO-SUPPRESSIVE REAGENT FTY720 BEFORE AND AFTER ONSET OF DIABETES
| Project/Area Number |
12670757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Ehime University |
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Principal Investigator |
KIDA Kaichi EHIME UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS, PROFESSOR, 医学部, 教授 (80093409)
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| Co-Investigator(Kenkyū-buntansha) |
KAINO Yukikazu EHIME UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS, ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (00204313)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | type 1 diabetes mellitus / FTY720 / non-obese diabetic mice (NOD) mice / insulitis / prevention / after onset of diabetes / pancreatic β-cell / immunotherapy |
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| Research Abstract |
Type 1 diabetes mellitus is known to result from chronic progressive islet inflammation and concomitant preferential β-cell destruction. The NOD mouse is an excellent animal model of spontaneous type 1 diabetes mellitus that shows many of the characteristics of humen type 1 diabetes mellitus. FTY720 is a chemical substance derived by modifying an immunosuppressive metabolite, ISP-1, from Isaria sinclairii, an ascomycete. Accelerated lymphocyte homing and apoptosis contribute to potent immunosuppressive effects of this drug.
This study has demonstrated that FTY720 prevents diabetes in NOD mice and prolongs the survival period after onset of the disease, indicating that treatment with FTY720 would be an effective strategy for protecting pancreatic β-cells from inflammatory insulitis in human type 1 diabetes mellitus.
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Report
(3 results)
Research Products
(11 results)
