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Physiological functions of polyunsaturated fatty acids and nutritional recommendation of the essential lipids for infants and toddlers

Research Project

Project/Area Number 12670777
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTeikyo University School of Medicine

Principal Investigator

SHIMASAKI Hiroyuki (2001-2002)  Teikyo Univ, Asso.Professor, 医学部, 助教授 (20112758)

阿部 敏明 (2000)  帝京大学, 医学部, 教授 (40101117)

Co-Investigator(Kenkyū-buntansha) 板倉 弘重  国立健康栄養研究所, 研究員 (20010366)
花香 里子  帝京大学, 医学部, 助手 (10276719)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsEssential fatty acid / polyunsaturated fatty acid / Brain lipid / Cholesterol / Infant formulas / 卵黄脂質 / コレステロール代謝 / ACAT / 脂質栄養 / 成長と発達 / 子白鼠 / HMG-CoA還元酵素 / 授乳期 / 離乳期
Research Abstract

Fatty acids have a variety of physiological functions such as energy supply, neural transmission, membrane structure, a precursor of biological active substances and etc. Long-chain polyunsaturated fatty acids (LCPUFA) which is essential for human development, is supplied to fetus and infants through cord blood and breast milk or/and infant formula, respectively, however, the mechanism still remains to be dissolved. We analyzed fatty acids from these materials and phospholipids from colostrum, comparing with that of infant formulas (IF) in Japan and recommended that PUFA should be added to the present infant formulas in Japan to produce better nutrition for infants and toddlers.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] S.Hanaka, et al.: "Gene expression related to cholesterol metabolism in mouse brain during development"Brain & Development. 22. 321-326 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] L.Wang, et al.: "Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women"Pediatrics International. 42. 14-20 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Shimizu, et al.: "Dietary Fish Oil for Hens Affects the Fatty Acid Composition of Egg Yolk Phospholipids and Gives a Valuable Food with an Ideal Balance of n-6 and n-3 Essential Fatty Acids for Human Nutrition"J.Oleo Science. 50. 797-803 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Shimasaki, et al.: "Dietary effect of docosahexaenoic acid-rich eggs on serum lipids in Real-"J.Oleo Science. 52. 109-119 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Hanaka: "Developmental regulation of cholesterol metabolism in the brain"帝京医学雑誌. 24. 41-55 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kaneko: "Long chain polyunsaturated fatty acids in cord blood and colostrum-"帝京医学雑誌. 24. 107-118 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Hanaka, T. Abe, H. Itakura, A. Matsumoto: "Gene expression related to cholesterol metabolism in mouse brain during development"Brain & Development. 22. 321-326 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] L. Wang, Y. Shimizu, S. Kaneko, S. Hanaka, T. Abe,H. Shimasaki, H. Hisaki, H. Nakajima: "Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women"Pediatrics International. 42. 14-20 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Shimizu, K. Arai, S. Ise, H. Shimasaki: "Dietary fish oil for hens affects the fatty acid composition of egg yolk phospholipids and gives a valuable food with an ideal balance of n-6 and n-3 essential fatty acids for human nutrition"J. Oleo Science,. 50. 797-803 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Shimasaki, E. Yamashita, Y. Shimizu, S. Ise: "Dietary effect of docosahexaenoic acid-rich eggs on serum lipids in healthy human subjects: A randomized double-blind controlled study"J. Oleo Science,. 52. 109-119. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Hanaka: "Developmental regulation of cholesterol metabolism in the brain"Teikyo Medical Journal. 24. 41-55. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Kaneko: "Long chain polyunsaturated fatty acids in cord blood and colostrum compared with maternal blood and infant formulas"Teikyo Medical Journal. 24. 107-118. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 金子衣野: "胎児、乳児の成長、発達に及ぼすn-3およびn-6系列多価不飽和脂肪酸の効果に関する栄養学的研究"帝京医学雑誌. 24(2). 107-118 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Liwen Warg et al.: "Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women"Pediatrics International. 42. 14-20 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yukiko SHIMIZU et al.: "Dietary Fish Oil for Hens Affects the Fatty Acid Composition of Egg Yolk Phospholipids and Gives a Valuable Food with an Ideal Balance of n-6 and n-3 Essential Fatty Acids for Human Nutrition"J.Oleo Science. 50(10). 797-803 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroyuki Shimasaki et al.: "Dietary effect of docosafexaenoic acid-rich, eggs on serum lipid in healthy human subjects"J.Oleo Science. 52(2). 109-119 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 花香 里子: "成長・発達期の脳におけるコレステロール代謝の変動"帝京医学雑誌. 24(1). 41-55 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Hanaka, et al.: "Gene expression related to cholosterol metabolism in mouse brain during denelopment"Brain Dev.. 22(5). 321-326 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 金子衣野: "胎児,乳児の成長、発達に及ぼすn-3およびn-6系列多価不飽和脂肪酸の効果に関する栄養学的研究"帝京医学雑誌. 24(2). 107-118 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.SHIMIZU et.al: "Dietary fish oil for hens affects the fatty acid composition of egg yolk phospholipids and gwes a valuable food whh"J.Oleo Science. 50(10). 797-803 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toshiaki Abe et al: "Infantile convulsions with mild gastroenteritis"Brain & Development. 22. 301-306 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Satoko Hanaka: "Gene expression related to cholesterol metabolism in mouse brain during development"Brain & Development. 22. 321-326 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toshiyuki Hikita: "Determination of N-acetyl-and N-glycolyeneuraminic acids in gangliosides by combination of neuraminidase hydrolysis and fluorometric high-performance liquid chromatography using a GM3 derivatives as an internal standard"Analytical Biochemistry. 281. 193-201 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasuko Fujita: "Girl with accelerated growth, hearing loss, inner ear anomalies, delayed myelination of the brain and del (22)(13.1q13.2)"American Journal of Medical Genetics. 92. 195-199 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 阿部敏明: "HMG-CoAレダクターゼ阻害薬"小児科診療. 63. 98-99 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 阿部敏明: "生活習慣病対策-高脂血症"モダンフィジシャン. 19. 862-865 (1999)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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