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Effect of polycmorphism in plasminogen activate inhavitor on the occunence ofcardiac complication in Kawasaki disease

Research Project

Project/Area Number 12670800
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

SHIRAHATA Akira  University of Occupational and Environmental Health, School of Medicine, Professor, 医学部, 教授 (10081712)

Co-Investigator(Kenkyū-buntansha) KANIZONO Junji  University of Occupational and Environmental Health, School of Medicine, Research Associate, 医学部, 助手 (50299616)
SAKAI Michio  University of Occupational and Environmental Health, School of Medicine, Research Associate, 医学部, 助手 (10279333)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsKawasaki desease / polymorphism / tissue plasminogen activator / plasminogen activator / cardiac complication / プラスミノゲン・アクチベーター・インヒビター
Research Abstract

1.Time course of fibrinolytic system in patients with Kawasaki disease (KD) during acute phase.
To determine whether the fibrinolytic system is related to the occurrence of cardiac ccmplication in KD, we measured tissue plasminogen activator (1PA), plasminogen activator inhibitor-1 (PAI-1), and related factors in the plasma of children with KD. TPA and PAI-1 were increased in acute phase. Ch the other hand, TPA/lPAI-1 ratio was lower in the cardiac complication group than in the no ccmplication group throughout the observation period These results indicate that a low fibrinolytic activity may be related to the occurrence of cardiac Duplication in KD.
2.Polymorphism in PAI-1 in KD
PAI-1 polymorphismwas investigated in patients with KD and controls. Genotype (4G, 5G allele of PAI-1gene) was determined, using PCR assays based on published method The distribution of 4G/4G, 4G/5G and 5G/5G genotype was similar in KD and control. On the other hand, weak association of homozygote of 4G with no cardiac ccmplication were observed in KD. These results provide preliminary evidence that polymorphism in PAI-1 does not contribute to occurrence of KD and cardiac complication in KD.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 白幡 聡: "小児の出血傾向の診断と治療の進め方"日本医事新報. 4020. 19-26 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakai M, Shirahata A et al.: "Low TPA relative to PAI-1 as a marker of cardiac complication in children with Kawasaki disease"Clin Appl Thrombosis/Hemostasis. 7・3. 214-218 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 酒井道生, 白幡 聡: "抗血小板療法の基礎と臨床"小児科診療. 64・8. 1175-1181 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 酒井道生, 白幡 聡 他: "乳児期発症例を含む血栓症多発の1家系"産業医科大学雑誌. 23・3. 297-305 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 白幡 聡: "紫斑・出血傾向"小児科診療. 64・11. 1766-1772 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushima S, Shirahata A et al.: "Normal prothrombin level in newborn infants by carinactivase-1 method"Seminars in Thrombosis and Hemostasis. 28(発表予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arai A., Shirahata A., et al.: "Detection of mononuclear cells as the source of the increased tissue factor mRNA in liver from IPS treated rats"thrombosis research. 7-3. 153-162 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakai M., Shirahata A., et al.: "Low TPA relative to PAI-1 as a marker of cardiac complication in children with Kawasaki disease"Chin Appl Thrombosis/Hemostasis. 7-3. 214-218 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakai M., Urano H., Iinuma A., Okamoto K., Ohasato K., Shirahata A.: "Afamily with multiple thrombosis including infancy occurrence"JUOEH. 23-3. 297-305 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukushima S., Shirahata A., et al.: "Normal prothrombin level in newborn infants by carinactivase- 1 method"Seminars in Thrombosis and Hemostasis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshioka A., Shima M., Fukutake K., Takamatsu J., Shirahata A., et al.: "Safety and efficacy of a new recombinant FVIII formulated with sucrose (rFVII-FS) in patients with haemophilia A : a long-term, multtcentre clinical study in Japan"Haemophilia. 7. 242-249 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shirahata A., Kamizono J., et al.: "Clinical trial to investigate the pliarmacokinetics, pharmacodynamics, safety, and eflficacy of recombinant factor VIIa in Japanese patients with hemophilia with inhibitors"Int J Hematol. 73. 517-525 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 白幡 聡: "小児の出血傾向の診断と治療の進め方"日本医事新報. 4020. 19-26 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakai M, Shirahata A et al.: "Low TPA relative to PAI-1 as a marker of cardiac complication in children with Kawasaki disease"Clin Appl Thrombosis/Hemostasis. 7・3. 214-218 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 酒井道生, 白幡 聡: "抗血小板療法の基礎と臨床"小児科診療. 64・8. 1175-1181 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 酒井道生, 白幡 聡: "乳児期発症例を含む血栓症多発の1家系"産業医科大学雑誌. 23・3. 297-305 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 白幡 聡: "紫斑・出血傾向"小児科診療. 64・11. 1766-1772 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fukushima S, Shirahata A et al.: "Normal prothrombin level in newborn infants by carinactivase-1 method"Seminars in Thrombosis and Hemostasis. 28(発表予定).

    • Related Report
      2001 Annual Research Report
  • [Publications] Shirakawa Y et al: "Difference in reactivity to vitamin K administration of the vitamin K dependent procoagulant PC and S and osteocalcin"Seminars in Thrombosis and Hemostasis. 26・1. 119-126 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Arai A et al: "Detection of mononuclear cells as the source of the increased tissue factor mRNA in liver from LPS treated rats"Thrombosis Research. 97・3. 153-162 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakai M et al: "Imbalances of the fibrinolytic system is related to the development of coronary complication in Kawasaki disease"Blood Coagulation & Fibrinolysis. (in press).

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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