| Project/Area Number |
12670830
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Dept. of Dermatology, Miyazaki Medical College (2001-2002)
Kagoshima University (2000) |
|---|
Principal Investigator |
SETOYAMA Mitsuru Miyazaki Medical College, Dermatology, Professor, 医学部, 教授 (30128433)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUROKAWA Motoki Miyazaki Medical College, Dermatology, Assist. Professor, 医学部, 講師 (90234591)
YOTSUMOTO Shin-ichi Kagoshima University, Dermatology, Assist. Professor, 医学部附属病院, 講師 (70244241)
|
|---|
| Project Period (FY) |
2000 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Apoptosis / ATLL / Eccrinegland / HTLV-I / ATL / 汗腺上皮 / 発汗異常 / Apoptosis / Eccrine gland / Sicca Syndrome |
|---|
| Research Abstract |
We have studied and confirmed that HTLV-1 infects not only lymphoid cells but also vascular endothelial cells and sweat gland epithelia. And, it is well known that virus-infected cells frequently exhibit apoptosis.
Thus, we investigated whether HTLV-1 infection caused apoptosis of the sweat gland epithelia in the specimen from ATLL patients and healthy HTLV-1 carriers.
As the results, apoptotic epithelial cells of the sweat glands were recognized from seropositive donors (14 of 31 cases of ATLL, 1 of 8 cases of carrier), but seronegative them. These apoptotic glands were always associated with CD8+ and TIA-1+ cell infiltration. These results also suggested that the event is relevant to sweating disturbance shown in ATLL patients.
|
