| Project/Area Number |
12670847
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | HOKKAIDO UNIVERSITY |
|---|
Principal Investigator |
TERAE Satoshi Hokkaido Univ., Grad. School of Medicine, Lec, 大学院・医学研究科, 講師 (40240634)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYASAKA Kazuo Hokkaido Univ., Grad. School of Medicine, Prof., 大学院・医学研究科, 教授 (60001939)
KATO Chietsugu Hokkaido Univ., Grad. School of Medicine, Inst., 大学院・医学研究科, 寄附講座教員 (10292012)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | Cerebral blood perfusion / Computed tomography / CT / Contrast medium / Ischemic cerebral diseases / PET / CBF / perfusion / Brain |
|---|
| Research Abstract |
To assess accuracy of dynamic, contrast-enhanced CT perfusion imaging, we compared cerebral blood flow (CBF) measured by the CT perfusion imaging (CT-CBF) with CBF by positron emission tomography (PET-CBF) in five normal volunteers and four patients in chronic stage of ischemic cerebral diseases. For CT per fusion, 370 or 350 mgI/ml of contrast material was injected via a superficial vein using power injector at a rate of 5 ml/sec. Single slice volume (8 mm x 4-collimation) was scanned for 30 - 60 seconds with 80 kVp and 1 second/rotation. We programmed a deconvolution method to analyze the CT perfusion data on personal computer. Arterial input function was determined by measuring time-density curve at the distal end of the internal carotid artery. We also developed a software to co-register PET data to CT images. On visual impression, apparently higher CBF along the cerebral surface was seen on CT-CBF maps, as compared to PET-CBF maps. However, contrast between gray and white matter, and contrast between the ischemic area and normal brain on CT-CBF were similar to those on PET-CBF. After exclusion of pixels that included relatively large vessels from CT-CBF, calculated CBF values by perfusion CT were almost identical to those by PET for the entire slice. The difference was +3 to +12% for the affected hemisphere, and -3 to +9% for the contralateral hemisphere in the patients. Linear regression analysis of CBF values between the CT-CBF and the PET-CBF maps showed relatively good correlation with a correlation coefficient (γ) varying in rang from 0.62 to 0.72. Dynamic, contrast-enhanced CT perfusion imaging is a promising technique for the accurate measurement of cerebral blood perfusion, and will provide valuable information on the severity of ischemic lesions.
|
