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A study of the efficacy of percutaneous bone cement injection osteoplasty combined with radiation therapy for painful bone metastases.

Research Project

Project/Area Number 12670858
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

TAKANAKA Tsuyoshi  Kanazawa University Hospital, Associate Professor, 医学部附属病院, 助教授 (00216673)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Takeshi  Kanazawa University Hospital, Instructor, 医学部附属病院, 講師 (50186748)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Keywordsbone metastasis / percutaneous vertebroplasty / percutaneous osteoplasty / bone cement / radiation therapy / CT fluoroscopy / VAS
Research Abstract

Between August 1997 and January 2003, 59 patients (26 men, 33 women; aged 36-80 years, mean 63 years) underwent percutaneous osteoplasty (POP) with methacrylate bone cement for painful bone ntetastases. Most of the metastases originated from lung (17 cases) and breast (10 cases). A total of 69 osteoplasties were performed at the same or different times and a total of 90 bones (77 vertebral spines, 7 sacrums, 3 acetabulums, 2 proximal femurs and 2 iliums) were treated with POP. Osteoplasty was performed under CT fluoroscopic guidance with cement injected at a volume of 1-15ml (average 4.3ml) per single injection. All procedures were safely completed and divided into 3 groups: Group A (POP only), Group B (POP first followed by radiation therapy (RT)), Group C (RT first followed by POP). The results in terms of pain relief obtained for the treated lesions according to the treatment method were evaluated on a 10cm visual analogue scale (VAS). The mean VAS score for Group A decreased from 7.3 to 1.3 before and after POP, that for Group B from 7.7 to 2.1 before and after POP and finally to 0.9 following RT after POP. The mean VAS score for Group C decreased from 8.0 to 5.9 before and after RT and finally to 1.4 following POP after RT. As a result, complete pain relief was achieved for 61% after POP and 77% after POP and combined RT. Characteristically, pain relief was achieved within 24 hours after POP for 77% of the responding lesions and local pain recurrence was rare. The results of our study show that POP produced immediate and long-term pain relief and combining RT with POP enhanced the pain relief. Percutaneous osteoplasty combined with radiation therapy thus represents an attractive treatment procedure for patients with painful bone metastases.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 高中 強: "乳癌腰椎転移に対し,CT透視下にて骨セメント注入による椎体形成術を行った1例"乳癌の臨床. 13(4). 744-745 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小林 健: "CT透視を用いた経皮的椎体形成術の有用性"IVR会誌. 14(3). 343-348 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kobayashi: "Percutaneous vertebroplasty guided by CT fluoroscopy"Radiology. 217(Suppl). 524 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小林 健: "椎体形成術における治療効果に影響を与える因子の検討"臨床放射線. 46(12). 1477-1482 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Takanaka: "Efficacy of percutaneous osteoplasty combined with radiotherapy for painful bone metastasis"Radiotherapy and Oncology. 58(Suppll). 110 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小林 健: "経皮的椎体形成術の実際"IVR会誌. 17(1). 17-22 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuyoshi Takanaka: "A case treated with bone cement injection vertebroplasty guided by CT fluoroscopy for painful lumbar spine metastasis"Japanese Journal of Breast Cancer. 13(4). 744-745 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Kobayashi: "Efficacy of percutaneous vertebroplasty under CT fluoroscopic guidance"Japanese Journal of Interventional Radiology. 14(3). 343-348 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Kobayashi: "Percutaneous vertebroplasty guided by CT fluoroscopy"Radiology. 217(supplement 1). 524 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Kobayashi: "Evaluation of the affecting factors to effectiveness for percutaneous vertebroplasty"Japanese Journal of Clinical Radiology. 46(12). 1477-1482 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuyoshi Takanaka: "Efficacy of percutaneous osteoplasty combined with radiotherapy for painful bone metastasis"Radiotherapy and Oncology. 58(supplement 1). 110 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Kobayashi: "Practice of percutaneous vertebroplasty"Japanese Journal of Interventional Radiology. 17(1). 17-22 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小林 健: "経皮的椎体形成術の実際"IRV会誌. 17(1). 17-22 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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