A study of the efficacy of percutaneous bone cement injection osteoplasty combined with radiation therapy for painful bone metastases.
| Project/Area Number |
12670858
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKANAKA Tsuyoshi Kanazawa University Hospital, Associate Professor, 医学部附属病院, 助教授 (00216673)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi Kanazawa University Hospital, Instructor, 医学部附属病院, 講師 (50186748)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | bone metastasis / percutaneous vertebroplasty / percutaneous osteoplasty / bone cement / radiation therapy / CT fluoroscopy / VAS |
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| Research Abstract |
Between August 1997 and January 2003, 59 patients (26 men, 33 women; aged 36-80 years, mean 63 years) underwent percutaneous osteoplasty (POP) with methacrylate bone cement for painful bone ntetastases. Most of the metastases originated from lung (17 cases) and breast (10 cases). A total of 69 osteoplasties were performed at the same or different times and a total of 90 bones (77 vertebral spines, 7 sacrums, 3 acetabulums, 2 proximal femurs and 2 iliums) were treated with POP. Osteoplasty was performed under CT fluoroscopic guidance with cement injected at a volume of 1-15ml (average 4.3ml) per single injection. All procedures were safely completed and divided into 3 groups: Group A (POP only), Group B (POP first followed by radiation therapy (RT)), Group C (RT first followed by POP). The results in terms of pain relief obtained for the treated lesions according to the treatment method were evaluated on a 10cm visual analogue scale (VAS). The mean VAS score for Group A decreased from 7.3 to 1.3 before and after POP, that for Group B from 7.7 to 2.1 before and after POP and finally to 0.9 following RT after POP. The mean VAS score for Group C decreased from 8.0 to 5.9 before and after RT and finally to 1.4 following POP after RT. As a result, complete pain relief was achieved for 61% after POP and 77% after POP and combined RT. Characteristically, pain relief was achieved within 24 hours after POP for 77% of the responding lesions and local pain recurrence was rare. The results of our study show that POP produced immediate and long-term pain relief and combining RT with POP enhanced the pain relief. Percutaneous osteoplasty combined with radiation therapy thus represents an attractive treatment procedure for patients with painful bone metastases.
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Report
(4 results)
Research Products
(13 results)
