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Establishment of easy method to measure absolute cerebral hemodymanics values using MR imaging

Research Project

Project/Area Number 12670880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

MIHARA Futoshi  Kyushu University, Fuculty of Medicine, Assoc. Prof., 大学院・医学研究院, 助教授 (80253615)

Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2000: ¥400,000 (Direct Cost: ¥400,000)
KeywordsBrain circulation / Perfusion image / MRI / MTT / CBF / Cerebral perfusion pressure / PET / SPECT / 脳灌流画像 / 磁気共鳴(MR) / 撮像条件 / 最適化
Research Abstract

It is necessary to optimize the MR parameters and contrast material administration method to measure the absolute values of cerebral hemodymanics with MR imaging. It is also necessary to develop, appropriate analytical software. Moreover, it is necessary to compare the MR method with the already established methods. The research process and results of this project are shown as follows.
1.The MR parameters, the administering method of the contrast material, and dosage were optimized for perfusion-weighted MR imaging. An appropriate analytical method was decided and analytical software was made. (Mihara F et al. Nippon Acta Radiol 61:369, 2001)
2.Mean transit time (MTT) obtained using perfusion-weighted MR imaging was comparison, with that obtained with positron emission tomography. The, MTT obtained using perfusion-weighted MR imaging and PET demonstrated statistically significant correlation (p<0.0001) (Mihara F. INNERVISION 17:67,2002)
3.The MTT obtained with perfusion-weighted MR imaging correlated statistically with cerebral blood flow (p<0.001), vascular reactivity (p<0.001) and oxygen extraction fraction (p<0.01). (Mihara F. Magn Reson Imaging 21:33,2003)
4.To clarify the utility of semi-quantitative cerebral blood flow (CBF) measurements using perfusion-weighted MR imaging, a comparison of this method with quantitative CBF obtained using PET was conducted. A statistically significant positive correlation was obtained between the CBF ratios (p<0.01). (Mihara F. Neuroreport 14:725,2003)
5.CBF obtained by perfusion-weighted MR imaging was slightly larger than that obtained by PET in normal volunteers. A relatively good correlation was observed between MR and PET measurements. (Kaneko K, Mihara F, et al. Academic Radiol 2004, in press)

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Kaneko K et al.: "Validation of the CBF, CBV and MTT values by perfusion MRI in chronic occlusive cerebrovascular disease."Academic Radiol. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F: "Semi-quantitative CBF and CBF ratios obtained using perfusion-weighted MR imaging."Neuroreport. 14・5. 725-727 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F: "Reliability of mean transit time obtained using perfusion-weighted MR imaging ; comparison with positron emission tomography."Magn Reson Imaging. 21・1. 33-39 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 三原 太: "脳循環諸量絶対値のMRによる極簡便な測定法の確立"INNERVISION. 17・8. 67 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F: "Correlation between proton magnetic resonance spectroscopic lactate measurements and vascular reactivity in cerebrovascular disease."Magn Reson Imaging. 18・9. 1167-1174 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaneko K, Mihara F et al.: "Validation of the CBF, CBV and MTT values by perfusion MRI in chronic occlusive cerebrovascular disease."Academic Radiol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F et al.: "Semi-quantitative CBF and CBF ratios obtained using perfusion-weighted MR imaging."Neuroreport. 14. 725-727 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F et al.: "Reliability of mean transit time obtained using perfusion-weighted MR imaging comparison with positron emission tomography."Magn Reson Imaging. 21. 33-39 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F et al.: "Establishment of easy method to measure absolute cerebral hemodymanic values using MR imaging"INNERVISION. 17. 67 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara F et al.: "Correlation between proton magnetic resonance spectroscopic lactate measurements and vascular reactivity in cerebrovascular disease."Magn Reson Imaging. 18. 1167-1174 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaneko K: "Validation of the CBF, CBV and MTT values by per fusion MRI in chronic occlusive cerebrovascular disease."Academic Radiol. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mihara F: "Semi-quantitative CBF and CBF ratios obtained using perfusion-weighted MR imaging."Neuroreport. 14・5. 725-727 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mihara F: "Reliability of mean transit time obtained using perfusion-weighted MR imaging ; comparison with positron emission tomography."Magn Reson Imaging. 21・1. 33-39 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 三原 太: "脳循環諸量絶対値のMRによる極簡便な測定法の確立"INNERVISION. 17・8. (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mihara F: "Correlation between proton magnetic resonance spectroscopic lactate measurements and vascular reactivity in cerebrovascular disease."Magn Reson Imaging. 18・9. 1167-1174 (2000)

    • Related Report
      2003 Annual Research Report
  • [Publications] 三原太: "脳循環諸量絶対値のMRによる極簡便な測定法の確立"INNERVISION. 17・8. 67 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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