| Project/Area Number |
12670907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
TAJIMA Hiroyuki FACULTY OF MEDICINE, DEPARTMENT OF RADIOLOGY, ASSOCIATE PRROFESSOR, 医学部, 助教授 (00188244)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Embolism, pulmonary / Interventional procedure / Thrombectomy / Catheter / Artery, pulmonary / Angiography |
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| Research Abstract |
Purpose : To evaluate the efficacy and safety of mechanical fragmentation, local tnrombolysis and manual tnrombo-aspiration in the treatment of acute massive pulmonary thromboembolism with hemodynamic impairment. Materials and methods : Within 3 years, 20 hemodynamically impairment patients were treated with thrombus fragmentation by mechanical action of modified rotating pigtail catheter. After embolus fragmentation, all patients received intrapulmonary injection of recombinant human-tissue plasminogen activator (rt PA), followed by manual thrombo-aspiration using a large lumen PTCA guiding catheter. Results : All patients survived and their clinical status improved. Angiography in all patients post treatment demonstrated improvement of the pulmonary perfusion. Mean pulmonary arterial pressure decreased statistically. Mean treatment time was 131 min. Conclusion : Mechanical fragmentation by rotating pigtail catheter with local fibrinolysis and manual thrombo-aspiration provided a rapid and safe improvement of the hemodynamic situation in acute massive pulmonary thromboembolism.
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