| Project/Area Number |
12670921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamagata University |
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Principal Investigator |
OTANI Koichi Yamagata University, Professor, 医学部, 教授 (00194192)
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| Co-Investigator(Kenkyū-buntansha) |
AOSHIMA Toshiaki Yamagata University, Assistant, 医学部, 助手 (50312723)
WADA Tadashi Yamagata University, Assistant, 医学部, 助手 (70292414)
TAKAHASHI Michihiro Yamagata University, Assistant Professor, 医学部, 講師 (80282200)
奥山 直行 山形大学, 医学部, 助手 (50282215)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | FLUVOXAMINE / CYP2D6 / CYP1A2 / GENETIC PLYMORHISM / PHARMACOKINETICS / PHARMOCODYNAMICS |
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| Research Abstract |
1) Effect of CYP1A2 inhibition by enoxacine or caffeine on the pharmacodynamics of fluvoxamine in healthy volunteers
In 8 male healthy volunteers, CYP1A2 inhibition by enoxacine 200 mg/day but not by caffeine 300 mg/day strengthened sleepiness of fluvoxamine 50 mg.
2) Effects of the CYP2D6 genotype and cigarette smoking on the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino-acid in Japanese depressed patients
In 49 depressed patients, the CYP2D6 genotype and CYP1A2 induction by cigarette smoking did not affect the steady-state plasma concentrations of fluvoxamine and fluvoxamino-acid.
3) Relationship between clinical effects of fluvoxamine and the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino-acid in Japanese depressed patients
In 49 depressed patients, therapeutic effect of fluvoxamine was dependent on the steady-state plasma concentrations of fluvoxamine and fluvoxamino-acid, but not related to the CYP2D6 genotype or CYP1A2 induction by cigarette smoking.
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