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Effects of the CYP2D6 genetic polymorphism and environmental factors on the pharmacokinetics and pharmacodynamics of fluvoxamine

Research Project

Project/Area Number 12670921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionYamagata University

Principal Investigator

OTANI Koichi  Yamagata University, Professor, 医学部, 教授 (00194192)

Co-Investigator(Kenkyū-buntansha) AOSHIMA Toshiaki  Yamagata University, Assistant, 医学部, 助手 (50312723)
WADA Tadashi  Yamagata University, Assistant, 医学部, 助手 (70292414)
TAKAHASHI Michihiro  Yamagata University, Assistant Professor, 医学部, 講師 (80282200)
奥山 直行  山形大学, 医学部, 助手 (50282215)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsFLUVOXAMINE / CYP2D6 / CYP1A2 / GENETIC PLYMORHISM / PHARMACOKINETICS / PHARMOCODYNAMICS
Research Abstract

1) Effect of CYP1A2 inhibition by enoxacine or caffeine on the pharmacodynamics of fluvoxamine in healthy volunteers
In 8 male healthy volunteers, CYP1A2 inhibition by enoxacine 200 mg/day but not by caffeine 300 mg/day strengthened sleepiness of fluvoxamine 50 mg.
2) Effects of the CYP2D6 genotype and cigarette smoking on the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino-acid in Japanese depressed patients
In 49 depressed patients, the CYP2D6 genotype and CYP1A2 induction by cigarette smoking did not affect the steady-state plasma concentrations of fluvoxamine and fluvoxamino-acid.
3) Relationship between clinical effects of fluvoxamine and the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino-acid in Japanese depressed patients
In 49 depressed patients, therapeutic effect of fluvoxamine was dependent on the steady-state plasma concentrations of fluvoxamine and fluvoxamino-acid, but not related to the CYP2D6 genotype or CYP1A2 induction by cigarette smoking.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report

Research Products

(16 results)

All Other

All Publications (16 results)

  • [Publications] K Otani, T Aoshima: "Pharmacogenitics of classical and new antipsychotic drugs"Therapeutic Drug Monitoring. 22. 118-121 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K Otani, K Mihara, et al.: "Clinical implications of pharmacogenetics of antidepressants"International Congress Series. 1244. 105-109 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K Yoshida, K Ito, K Sato, et al.: "Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depresses patients"Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26. 383-386 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K Ito, K Yoshida, et al.: "A variable number of tandem repeats in the serotonin transporter gene doe not affect tne antidepressant response of fluvoxamine"Psychiatry Research. 111. 235-239 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K Sato, K Yoshida, et al.: "Association between-1438G/A promoter polymorphism in the 5-HT2A receptor gene and fluvoxamine response in Japanese Patients with depression"Neuropsychobiology. 46. 136-140 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K Yoshida, S Naito, Takahashi H et al.: "Monoamione oxidase : A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patiens with depression"Progress in Neuro -Psychopharmacology and Biological Psychiatry. 26. 1279-1283 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] G Gerstenberg, T Aoshima, et al.: "Effects of the CYP2D6 genotype and cigarette smoking on the steady-state plasma concentration of fluvoxamine and its major metabolite fluvoxamino-acid in Japanese depressed patient"Therapeutic Drug Monitoring. (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] G Gerstenberg, T Aoshima, et al.: "Relationship between clinical effects of fluvoxamime and the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino-acid in Japanese depressed patients"Psychopharmacology. (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Otani, T. Aoshima: "Pharmacogenetics of Classical and New antipsychotic drugs"Therapeutic Drug Monitoring. 22. 118-121 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Otani, K, Mihara et al.: "Clinical implications of pharmacogenetics of antidepressants"International Congress Series. 1244. 105-109 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshida, K. Ito, et al.: "Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients"Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26. 383-386 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Ito, K. Yoshida, et al.: "A variable number of tandem repeats in the serotonin transpoter gene does not affect the antidepressant response to fluvoxamine"Psychiatry Research. 111. 235-239 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Sato, K. Yoshida, et al.: "Association between - 1438G/A Promoter polymorphism in the 5-HT2A receptor gene and fluvoxamine response in Japanese patients with major depressive disorder"Neuropsychobiology. 46. 136-140 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshida, S. Naito, et al.: "Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder"Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26. 1279-1283 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] G. Gerstenberg, T. Aoshima, et al.: "Effects of the CYP2D6 genotype and cigarette Smoking on the stead-state plasma concentration of fluvoxamine and its metabolite flivoxamino-acid in Japanese depressed patients"Therapeutic Drug Monitoring. (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] G. Gerstenberg, T. Aoshima, et al.: "Relationship between clinical effects of fluvoxamine and steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamine-acid in Japanese depressed patientas"Psychopharmacology. (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary

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Published: 2000-03-31   Modified: 2016-04-21  

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