| Project/Area Number |
12670928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWANAMI Akira (2001) Faculty of Medicine, The University of Tokyo, Associate Professor, 医学部・附属病院, 助教授 (80276518)
大久保 敏之 (2000) 東京大学, 医学部・附属病院, 講師 (50203732)
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| Co-Investigator(Kenkyū-buntansha) |
YUMOTO Masato Faculty of Medicine, The University of Tokyo, Associate, 医学部・附属病院, 助手 (30240170)
IRAMINA Keiji Faculty of Medicine, The University of Tokyo, Associate Professor, 医学部・大学院・医学系研究科, 助教授 (20211758)
ITOH Kenji Post graduate School of Medicine, The University of Tokyo, Associate, 医学部・大学院・医学系研究科, 助手 (80010106)
岩波 明 東京大学, 医学部・附属病院, 助教授 (80276518)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ERP / MEG / MMN / NI / P300 / Schizophrerenia / NI / 精神分裂症 / 脳磁図 / 事象関連電位 / 核磁気共鳴画像(MRI) / 認知障害 |
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| Research Abstract |
High-density event-related potential (ERP) recording system and high-density MEG recording system were used to examine the brain function and sex difference in mental disorders. Subjects were in patients with schizophrenia and autism. Mismatch negativity (MMN) in response to the change of vowels is significantly reduced in schizophrenia, which suggested the impairment of language processing. P300 amplitude was associated with the severity of though, disorder and was also associated with the global cognitive impairment.
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